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Modell lab

@jwmodell.bsky.social

Modell lab @jwmodell.bsky.social · 27/03/2026

How do you kill a MRSA superbug armed with 15 different anti-phage defense systems? You make a smarter phage. Check out our latest preprint on overcoming bacterial immunity using defense-guided engineering to build durable therapeutic phage cocktails! Led by Sarah Voss. doi.org/10.64898/202...

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Modell lab @jwmodell.bsky.social · 25/02/2025

Check out our latest article by graduating PhD candidate Nick Keith - CRISPR-Cas systems exploit the dormant lifecycle of temperate phages to create immunological memories under non-lytic conditions. www.cell.com/cell-host-mi...

cell.com

Bacteria exploit viral dormancy to establish CRISPR-Cas immunity

Keith et al. show that temperate phages present two unique opportunities for CRISPR-Cas immunizations relative to lytic counterparts. First, immunizations occur preferentially when phages choose lysog...

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