The accumulation and impact of senescent cells in age-related diseases are increasingly characterized. However, the mechanisms underlying their accumulation and their causative role in age-associated ...

Le vieillissement entraîne une accumulation de cellules sénescentes qui échappent au système immunitaire et contribuent à des maladies chroniques telles que l

Iltis, Moskalevska and colleagues investigate how the innate immune system regulates the age-related accumulation of senescent cells. They show that upregulation of the GD3 ganglioside-based immune ch...

This study identifies a novel immune checkpoint in senescent cells that is linked to the ganglioside GD3 and that contributes to the evasion of immune clearance by these cells and to aging and age-rel...

Basurco and Abellanas et al. discuss how immune system aging negatively impacts the brain and propose immune rejuvenation as a strategy to combat cognitive decline and sustain lifelong brain health.

This study identifies a novel immune checkpoint in senescent cells that is linked to the ganglioside GD3 and that contributes to the evasion of immune clearance by these cells and to aging and age-rel...

Nature Aging - This study identifies a novel immune checkpoint in senescent cells that is linked to the ganglioside GD3 and that contributes to the evasion of immune clearance by these cells and to...