iiinova — where your digital self keeps evolving

Reposted by Jesper Svejstrup

Hari Kunzru @harikunzru.bsky.social · 12/11/2025

One day the US will have to face the shame and horror of what has happened here: that a cabal of wealthy people have elevated a monster into the most powerful person in the world www.nytimes.com/2025/11/12/u...

nytimes.com

Epstein Alleged in Emails That Trump Knew of His Conduct

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Jesper Svejstrup @jsvejstrup.bsky.social · 12/11/2025

I’m very happy to share Zhong Han’s beautiful work on the biochemical function of Senataxin, encoded by a gene that is mutated in rare and early-disabling neurodegenerative diseases. Turns out it rescues backtracked RNA polymerase II during early transcription! www.sciencedirect.com/science/arti...

sciencedirect.com

A role for human senataxin in contending with pausing and backtracking during transcript elongation

Senataxin (SETX) regulates RNA polymerase II (RNAPII) transcription and helps maintain genome stability, at least partly by suppressing R-loops. Howev…

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Jesper Svejstrup @jsvejstrup.bsky.social · 26/09/2025

I'm very happy to share this review, written with Dan Blears, on a new interpretation of promoter-proximal pausing in the context of a transcription checkpoint. We're not the only ones with these ideas, but they've not been sufficiently explored the way we do here: genesdev.cshlp.org/content/earl...

genesdev.cshlp.org

Transcription quality control at the promoter-proximal checkpoint

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

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Jesper Svejstrup @jsvejstrup.bsky.social · 03/05/2025

Excited to share our latest paper, now online in Molecular Cell. First, it shows that the RNAPII-CTD kinases CDK9 and CDK12 are Ser5-Ser2 kinases. Secondly, it describes the activation mechanism of CDK12/13 by PAF1C complex. Congratulations to David López Martínez and coauthors! lnkd.in/d_nbfMht

lnkd.in

This link will take you to a page that’s not on LinkedIn

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Jesper Svejstrup @jsvejstrup.bsky.social · 13/02/2025

Looking for 2 or more highly motivated PhD students to join our quest to understand the interplay between gene expression, genome instability, and human disease jobportal.ku.dk/phd/?show=16... Deadline: March 6, 2025 Please share

jobportal.ku.dk

PhD fellowships at the Center for Gene Expression

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Jesper Svejstrup @jsvejstrup.bsky.social · 13/02/2025

Setting up shop in advance of closing our profile on X.

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