iiinova — where your digital self keeps evolving

John P. Overington @jpoverington.bsky.social · 16/03/2026

I mostly do bookcases for our book collections. Some restoration of older furniture. Next project is a lecturn for my office, do when I present to no-one!

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John P. Overington @jpoverington.bsky.social · 16/03/2026

I’m an obsessive organiser of things.

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John P. Overington @jpoverington.bsky.social · 15/03/2026

Finally mounted my patternmakers nice on the bench. Five axes!

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John P. Overington @jpoverington.bsky.social · 02/03/2026

Was browsing an antique book store in Houston this afternoon and found the treasure. 1959, at the cusp of the molecular biology revolution.

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John P. Overington @jpoverington.bsky.social · 09/02/2026

Does anyone know of a whitespace markup plugin for safari. You know, turns that pesky hidden text to red/green whatever?

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John P. Overington @jpoverington.bsky.social · 01/02/2026

Looks like the cold weather in Houston is over for now, so my best buddies are out of their cover and getting a tan again. The bigger ones should move out of the house later. But one of them flowered like crazy when moved inside.

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John P. Overington @jpoverington.bsky.social · 29/01/2026

I’m looking for a consultant for some part time remote work. Ideal profile would be 25+ years in med chem/pharmacology, remembers the mergers and acquisitions that happened in pharma and is a dab hand at navigating research codes like CS-045, CI-911 and GR-92132X. If this sounds fun, get in touch!

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John P. Overington @jpoverington.bsky.social · 03/01/2026

Yes. It’s my webmeeting background. Occasionally people don’t believe it’s real, so I shake the flags.

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John P. Overington @jpoverington.bsky.social · 02/01/2026

Spent the early part of the afternoon curating some of the Lego and framing the new portrait.

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John P. Overington @jpoverington.bsky.social · 02/01/2026

So, I mailed the BBC with this, and they’ve already fixed the error, and flagged the change. Great job BBC!!

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John P. Overington @jpoverington.bsky.social · 02/01/2026

The BBC news site is usually great, but I wish that health stories were better proof read and verified. For example, this article mentions the gas nitric acid www.bbc.com/future/artic... of course, it should be nitric oxide.

bbc.com

The surprising benefits of a glass of orange juice

The habit of drinking a glass of orange juice can have a considerable effect on your health.

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John P. Overington @jpoverington.bsky.social · 22/12/2025

Went to Barnes and Noble today to buy some Xmas presents for the family. Ended up getting me a present instead. It is a superb book so far.

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John P. Overington @jpoverington.bsky.social · 30/11/2025

Today I have mostly been sorting the garage.

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John P. Overington @jpoverington.bsky.social · 03/10/2025

I was 13. The swearing on Plaistow Patricia, the wonderful double entendres and the jolly pathos. My Old Man, I still cry at. Cuts deep.

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John P. Overington @jpoverington.bsky.social · 30/09/2025

Apparently it’s 48 years ago since New Boots and Panties was released. A true classic album, survived the test of time for sure!

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John P. Overington @jpoverington.bsky.social · 26/09/2025

The now legend of the gluing of the album covers, and the surrealist concept of destroying other records in the store using the cover, I think it is unmatched

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John P. Overington @jpoverington.bsky.social · 26/09/2025

For self conscious pseudo-intellectual teenagers from post-industrial Britain in the 1980s this is big news. For the rest of the world - nothing to see here.

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Reposted by John P. Overington

Andrew White 🐦‍⬛ @andrew.diffuse.one · 26/09/2025

I finished my estimate on required compute to make an atomic-resolution virtual cell: 10^38 FLOPs to simulate a human cell for 1 day. We should be able to do this simulation in 2074 using 200 TW of power. 1/3

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John P. Overington @jpoverington.bsky.social · 24/09/2025

What’s wrong with wc on the command line?

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John P. Overington @jpoverington.bsky.social · 07/09/2025

Nostalgia ain’t what it used to be. Just found a microfiche. Big stack of these. If only I had the reader. I bet they’re museum pieces now.

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John P. Overington @jpoverington.bsky.social · 07/09/2025

Just sorting through some old files. Really fun to step back in time. This must have been 1988 or so. Acetates, permanent markers. None of your AI assistants in putting this together. And it shows 😂😂

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John P. Overington @jpoverington.bsky.social · 01/09/2025

As a Brit expat in the States, it’s sad to see that access to the BBC News website is now paywalled. $90 a year!

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John P. Overington @jpoverington.bsky.social · 22/08/2025

It’s August in our home, and that means getting ready for Halloween!! The theme this year (apparently) is Labyrinth - here is David Bowie.

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John P. Overington @jpoverington.bsky.social · 14/08/2025

A sort of nerdy question around licenses. Imagine I subscribe to a journal in which they don’t allow text mining on the content. Seems fair. But if is store the pdf locally, then my Mac will index it and allow full text searching. Does this count as text mining?

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John P. Overington @jpoverington.bsky.social · 06/08/2025

Congratulations!! I heard that a metric to aim for is an H-index that matches your age; hang on, or was it your waist size?

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John P. Overington @jpoverington.bsky.social · 05/08/2025

Getting frustrated with the number of resources that disappear, change terms of use, etc. Seems cheeky that people publish in places like NAR Database with an 'open' resource, then flip to closed. Tempted to put together a table of all the NAR DB resources and plot existence/current license....

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John P. Overington @jpoverington.bsky.social · 20/07/2025

And while I’m thinking of Nature, their typography has gone downhill. The spacing between words in titles is now atrocious! Defense against OCR LLM tokenization or just poor visual design? 🤣

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John P. Overington @jpoverington.bsky.social · 20/07/2025

More seriously though, have there ever been any scholarly reviews of reliability of patent literature for fakery. I realise there are loads of batshit crazy teleportation patents, so restricting to credible applicants/areas should be easy to do.

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John P. Overington @jpoverington.bsky.social · 20/07/2025

Bit of an insult for Nature magazine in the Google response to asking if fake patents and fake publications are different.

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Reposted by John P. Overington

Stephen Curry @scurry.bsky.social · 16/07/2025

The times they are a changin’.

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Reposted by John P. Overington

Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social · 02/07/2025

CASP is the main reason the protein structure prediction technology and research field advanced over the last 30 years. And the main reason AI based methods have been accepted and widely applied in biology. So shortsighted of NIH to postpone or even halt funding. John Moult is a scientific hero.

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John P. Overington @jpoverington.bsky.social · 02/07/2025

There is this table of spelling differences from Clarivate webofscience.help.clarivate.com/en-us/Conten... not sure why pantyhose and pajamas made the science list though.

webofscience.help.clarivate.com

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John P. Overington @jpoverington.bsky.social · 01/07/2025

That's it. It's done. I am no longer on the other place. I'm going to miss some of the science on there, and in particular the biotech analyst community seems stuck there, but enough was enough. It had to go.

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John P. Overington @jpoverington.bsky.social · 01/07/2025

Thanks, it works to some extent on specific examples, but I want a fairly comprehensive list to help with automated canonicalization/localisation of a large number of text documents. Also in search interface implementation.

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John P. Overington @jpoverington.bsky.social · 01/07/2025

Is there anywhere online a free lexicon for alternate spelling of scientific terms between US and UK English. Something that contains the equivalence of sulphotransferase = sulfotransferase, protease = proteinase, etc. But also smart to know that synthase and synthetase are different concepts.

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John P. Overington @jpoverington.bsky.social · 01/07/2025

UI oddity of the day - a box to ask if I'm human, which looks like the only option I have is to click to say no, turns out it's a slider hiding as a tick box.

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John P. Overington @jpoverington.bsky.social · 14/06/2025

It’s my son’s birthday, so we are at a Metallica concert.

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John P. Overington @jpoverington.bsky.social · 19/05/2025

Would be a shame if during peer review, one of the questions was around ‘what does alphafold say about this region?’

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John P. Overington @jpoverington.bsky.social · 09/05/2025

A long day ahead, flying back home from Hamburg via Munich. Really enjoyed the CSSB 2025 conference, learnt so much; realised how much I missed virology.

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John P. Overington @jpoverington.bsky.social · 07/05/2025

At DESY in Hamburg at CSSB for a few days. I’ll speak on structural biology and systems approaches in drug resistance, with a little splash of AI thrown in. I love these big science campuses.

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John P. Overington @jpoverington.bsky.social · 03/05/2025

I bought a really cute cactus today. Put it in plastic bag, then managed to enter glochid hell. Here is my hand with PVA glue waiting to dry.

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John P. Overington @jpoverington.bsky.social · 27/04/2025

Taking the total of 7 novel drugs approved so far in 2025 would point towards a total approval number for the year of around 18-22. A number not matched since the approval drought two decades ago (2002-2006).

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John P. Overington @jpoverington.bsky.social · 27/04/2025

We are about a third of the way through the year, and so about a third of the yearly count should have been approved to date. This ratio is preserved pretty well for previous years.

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John P. Overington @jpoverington.bsky.social · 27/04/2025

The approval of new differentiated drugs that improve on current therapies and particularly the approval of novel drugs for currently untreated diseases are the heartbeat of progress of the pharmaceutical industry and improved human health.

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