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João Paulo Capela

@jpcapela.bsky.social
212 followers 52 following 42 posts

Farmacêutico, PhD em Toxicologia, Professor Uni. Farmacologia e Toxicologia 🧪🔬🧠🇵🇹 Pharmacist, PhD in Toxicology, Uni. Professor of Pharmacology and Toxicology 🧪🔬🧠 🇪🇺 Views my own! scholar.google.pt/citations?user=xl…

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Reposted by João Paulo Capela
Discover Journals @discover.springernature.com · 07/10/2026
An editorial in Discover Toxicology introduces the expertise and experience of the journal's editorial board, including the section editors who comprise its academic leadership, and invites researchers from the toxicology community to publish their next findings in this inclusive platform. #MedSky
bit.ly
Discover Toxicology, the future journal for your toxicology research
Discover Toxicology -
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João Paulo Capela @jpcapela.bsky.social · 19/09/2026
Very nice study! #ScienceSky #PharmSky #ToxSky #MedSky #NeuroSky 🧪
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João Paulo Capela @jpcapela.bsky.social · 27/05/2026
Discover Toxicology, the future journal for your toxicology research link.springer.com/article/10.1... #ScienceSky #PharmSky #ToxSky #MedSky #NeuroSky 🧪
link.springer.com
Discover Toxicology, the future journal for your toxicology research - Discover Toxicology
Discover Toxicology -
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João Paulo Capela @jpcapela.bsky.social · 01/05/2026
Our latest work conducted with Methylphenidate, first-line to treat ADHD: "Repeated Oral Methylphenidate Administration Evokes Changes in Brain Plasticity Proteins in Juvenile Wistar Kyoto Rats: Evidence for Sex-Related Differences" Neurochem Res 51, 90 (2026). doi.org/10.1007/s110...
 AI-generated visual Abstract
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João Paulo Capela @jpcapela.bsky.social · 06/03/2026
Uma luz que nos deixou, mas continuará sempre a brilhar! Sentidas condolências à família e amigos.
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João Paulo Capela @jpcapela.bsky.social · 26/02/2026
#PharmSky #ToxSky #MedSky #NeuroSky 🧪
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João Paulo Capela @jpcapela.bsky.social · 26/02/2026
Check our latest work on Methylphenidate, first-line pharmacotherapy for Attention Deficit Hyperactivity Disorder (ADHD). It's published open access in Neurochemical Research. doi.org/10.1007/s110... #PharmSky #ToxSky #MedSky #NeuroSky 🧪
doi.org
Repeated Oral Methylphenidate Administration Evokes Changes in Brain Plasticity Proteins in Juvenile Wistar Kyoto Rats: Evidence for Sex-Related Differences - Neurochemical Research
Methylphenidate (MPH) is first-line pharmacotherapy for Attention Deficit Hyperactivity Disorder (ADHD). Misdiagnosis and misuse raise concerns about exposing children and adolescents to MPH. This stu...
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João Paulo Capela @jpcapela.bsky.social · 26/02/2026
Discover Toxicology, published by Springer Nature, invites submissions of Reviews on hot topics in Toxicology. Full fee waiver if your article is submitted before the end of May. Please DM or contact me with any questions and request a formal invitation. link.springer.com/journal/44339
link.springer.com
Discover Toxicology
Discover Toxicology is an open access journal publishing research across all aspects of toxicology and its applications in research, development and society. ...
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João Paulo Capela @jpcapela.bsky.social · 23/09/2025
The EU is relying on Science based facts! #PharmSky #ToxSky #MedSky 🧪
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João Paulo Capela @jpcapela.bsky.social · 23/09/2025
As autoridades de saúde Portuguesas e Europeias estão a funcionar bem. Triste caso este da FDA nos EUA associar paracetamol com autismo, descredibilizando a ciência. Na EU e em Portugal acreditamos na Ciência! www.infarmed.pt/web/infarmed... #PharmSky #MedSky #ToxSky
infarmed.pt
Uso de paracetamol durante a gravidez mantém-se inalterado na UE
Infarmed
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João Paulo Capela @jpcapela.bsky.social · 29/07/2025
#PharmSky #ToxSky #MedSky #NeuroSky 🧪
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João Paulo Capela @jpcapela.bsky.social · 29/07/2025
Discover Toxicology, journal published by Springer Nature invites you to submit full-length or review articles on the “Toxicity of New Psychoactive Substances (NPS)”. Full fee waiver if your article is submitted by the end of October 2025. Please DM me for questions. link.springer.com/journal/44339
link.springer.com
Discover Toxicology
Discover Toxicology is an open access journal publishing research across all aspects of toxicology and its applications in research, development and ...
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Reposted by João Paulo Capela
Discover Journals @discover.springernature.com · 24/07/2025
Aligning with this year's World Environment Day theme “End Plastic Pollution," Discover Toxicology has launched a topical Collection: Toxicological Impacts of Microplastics in Freshwater Ecosystems. Submission Deadline: 31 Oct 2025!
bit.ly
Discover Toxicology
Discover Toxicology is an open access journal publishing research across all aspects of toxicology and its applications in research, development and ...
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Reposted by João Paulo Capela
Springer Nature @springernature.com · 09/06/2025
Have you taken part in Nature’s global survey of PhD students? We’ve had thousands of responses so far and would love to hear from you too. It should take no more than 15 mins and you can opt into a prize draw at the end. Survey closes 11 June. spklr.io/63320hAcC #PhDStudent
Nature’s global survey of PhD students
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João Paulo Capela @jpcapela.bsky.social · 06/06/2025
The European Drug Report 2025 is out. Cannabis remains by far the most commonly consumed illicit drug in EU, which is followed by Cocaine. Synthetic cathinones, which I study, are increasingly integrated into EU drug market. www.euda.europa.eu/publications... #PharmSky #ToxSky #MedSky 🧪
euda.europa.eu
European Drug Report 2025: Trends and Developments | www.euda.europa.eu
The European Drug Report 2025: Trends and Developments presents the EUDA’s latest analysis of the drug situation in Europe.
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João Paulo Capela @jpcapela.bsky.social · 06/06/2025
To support World Environment Day, the journal Discover Toxicology has selected four articles related to environmental toxicology that discuss human impact on the environment. See them at: communities.springernature.com/posts/world-... #PharmSky #ToxSky #MedSky 🧪
communities.springernature.com
World Environment Day 2025
Celebrating World Environment Day by showcasing our Discover Toxicology content on environmental toxicology and calling for papers
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João Paulo Capela @jpcapela.bsky.social · 06/03/2025
I don’t think AI can help in reviewing, and more importantly manny journals do not allow it for some very good reasons. I rejected a paper recently because it was found that it was clearly AI written! However, using AI to fine tune English should be fine. #PharmSky #ToxSky #MedSky #NeuroSky 🧪
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João Paulo Capela @jpcapela.bsky.social · 28/01/2025
More one among manny in the EU! www.reuters.com/world/europe... #PharmSky #ToxSky #MedSky #NeuroSky 🧪
reuters.com
EU medicines agency quits X, moves to Bluesky
The European Medicines Agency (EMA) said on Monday it would no longer post on X and would use rival Bluesky instead, becoming the latest organisation to quit a social media platform that some have criticised for its content.
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Reposted by João Paulo Capela
João Paulo Capela @jpcapela.bsky.social · 23/01/2025
I'm writing about amphetamine therapeutic use on obesity. I mean d-amphetamine or the racemic mixture, not other amphetamine-like drug. Can anyone tell if amphetamine is still approved in any country for obesity or weight loss? Thanks! #Amphetamine #PharmSky #ToxSky #MedSky #NeuroSky 🧪
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João Paulo Capela @jpcapela.bsky.social · 23/01/2025
Clinical trials back then agreed in a minor, but statistically significant effect. The problems are the adverse events like cardiovascular and potential abuse.
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João Paulo Capela @jpcapela.bsky.social · 23/01/2025
I'm writing about amphetamine therapeutic use on obesity. I mean d-amphetamine or the racemic mixture, not other amphetamine-like drug. Can anyone tell if amphetamine is still approved in any country for obesity or weight loss? Thanks! #Amphetamine #PharmSky #ToxSky #MedSky #NeuroSky 🧪
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João Paulo Capela @jpcapela.bsky.social · 22/01/2025
Our latest on Melatonin in food supplements and Medicines in Portugal. Up to 2mg is considered a food supplement, above a medicine! Food supplements contain melatonin and plant extracts and should be more carefully studied. www.scielo.br/j/bjps/a/5t5... #PharmSky #ToxSky #MedSky #NeuroSky 🧪
scielo.br
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João Paulo Capela @jpcapela.bsky.social · 16/01/2025
More one good news for science 🧪
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João Paulo Capela @jpcapela.bsky.social · 21/12/2024
Congratulations Vera for receiving this prestigious scientific career recognition prize! Muitos parabéns Vera por este merecido prémio de reconhecimento da tua carreira científica! 🤗🤗🤗🎉🎉🎉 🧪🔬 pt.linkedin.com/posts/vera-m...
pt.linkedin.com
Vera Marisa Costa no LinkedIn: É com grande orgulho que recebi, no dia 18 de dezembro de 2024, o Prémio…
É com grande orgulho que recebi, no dia 18 de dezembro de 2024, o Prémio Nunes Correa Verdades de Faria, atribuído pela Santa Casa da Misericórdia de Lisboa…
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João Paulo Capela @jpcapela.bsky.social · 17/12/2024
Good day for Science! Drugs should be used following solid proof of efficacy without serious adverse events. #PharmSky #ToxSky #MedSky #NeuroSky 🧪 www.science.org/content/arti...
science.org
Infamous paper that popularized unproven COVID-19 treatment finally retracted
Study on hydroxychloroquine by Didier Raoult and colleagues gets pulled on ethical and scientific grounds
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João Paulo Capela @jpcapela.bsky.social · 13/12/2024
For those interested in the anxiolytic effect of psychedelics I leave an interesting read. It seems interesting the possibility to dissociate the antianxiety effect of psychedelics from their hallucinogenic ones. #PharmSky #ToxSky #MedSky #NeuroSky 🧪 www.the-scientist.com/trippy-scien...
the-scientist.com
Trippy Science Unravels the Mystery of Psychedelics’ Antianxiety Effects
Researchers mimic the antianxiety effects of psychedelics by identifying and activating specific brain regions in an important step towards developing therapeutics that do not cause hallucinations.
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João Paulo Capela @jpcapela.bsky.social · 03/12/2024
Found this recent study on MDMA #ecstasy pharmacokinetics in humans. For those interested in the therapeutic prospects in PSTD, MDMA is a potent CYP2D6 inhibitor it can have relevant drug–drug interactions. ascpt.onlinelibrary.wiley.com/doi/full/10.... #PharmSky #ToxSky #MedSky #NeuroSky 🧪
ascpt.onlinelibrary.wiley.com
MDMA pharmacokinetics: A population and physiologically based pharmacokinetics model‐informed analysis
Midomafetamine (3,4-methylenedioxymethamphetamine [MDMA]) is under the U.S. Food and Drug Administration review for treatment of post-traumatic stress disorder in adults. MDMA is metabolized by CYP2D...
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João Paulo Capela @jpcapela.bsky.social · 02/12/2024
That brings me back good memories, when I stayed until late hours I the lab✌️🧠🧪
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João Paulo Capela @jpcapela.bsky.social · 27/11/2024
Here is a paper, already with some years, that reviews the potential neurotoxicity of MDMA. #PharmSky #ToxSky #MedSky #NeuroSky 🧪 link.springer.com/article/10.1...
link.springer.com
Molecular and Cellular Mechanisms of Ecstasy-Induced Neurotoxicity: An Overview - Molecular Neurobiology
“Ecstasy” [(±)-3,4-methylenedioxymethamphetamine, MDMA, XTC, X, E] is a psychoactive recreational hallucinogenic substance and a major worldwide drug of abuse. Several reports raised the concern that ...
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João Paulo Capela @jpcapela.bsky.social · 27/11/2024
MDMA could be helpful in PSTD or other brain disorders. There should be clinical trials not only showing effectiveness but also safety, not only in the short but also in the long term. Caution is required due to the potential neurotoxicity and hepatotoxic actions of MDMA and it’s metabolites. 🧪
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João Paulo Capela @jpcapela.bsky.social · 25/11/2024
Concordo plenamente com a hipocrisia social. A nível universitário, por exemplo, há muita publicidade e patrocínios de bebidas alcoólicas, que a meu ver deviam ser repensados a favor da saúde pública.
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João Paulo Capela @jpcapela.bsky.social · 23/11/2024
Mais uma investigadora de renome a dizer o óbvio! O financiamento da FCT no próxima OE vai baixar e seguramente no ano seguinte será igual. Se já estávamos com um nível baixo de financiamento da FCT, vamos ficar ainda pior!
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João Paulo Capela @jpcapela.bsky.social · 22/11/2024
“For scientists the network is starting to look like home.” Strongly agree. I never had so many scientist interacting with my posts like I do now in Bluesky. #PharmSky #ToxSky #MedSky #NeuroSky 🧪 www.science.org/content/arti...
science.org
Like ‘old Twitter’: The scientific community finds a new home on Bluesky
After recent changes to Elon Musk’s X, a gradual migration turns into a stampede
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João Paulo Capela @jpcapela.bsky.social · 22/11/2024
Great. Add me, thanks.
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João Paulo Capela @jpcapela.bsky.social · 21/11/2024
Thanks for your interest. Bit amphetamine and methylphenidate are used in ADHD. So in controlled doses and settings they can be therapeutically useful. The major problem with these two drugs are cardiovascular, and trials reveal no major adverse effects that could undermine its use.
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João Paulo Capela @jpcapela.bsky.social · 21/11/2024
I understand your concerns regarding the cardiovascular adverse effects, which no doubt should be given attention. The clinical trails did not show that adverse effects under control doses and settings were a problem. They did reveal mixed results, some improved others detailed no improvement.
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João Paulo Capela @jpcapela.bsky.social · 21/11/2024
Thanks for your interest in our work. In fact regarding the brain it makes sense the use of stimulants for this neurological disorders. In particular methylphenidate, that is used to treat ADHD, has been given more attention for stroke or TBI.
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João Paulo Capela @jpcapela.bsky.social · 21/11/2024
For those in the field, look at our latest review article on: "Amphetamine and methylphenidate potential on the recovery from stroke and traumatic brain injury: a review" www.degruyter.com/document/doi... #PharmSky #ToxSky #MedSky #NeuroSky 🧪
degruyter.com
Amphetamine and methylphenidate potential on the recovery from stroke and traumatic brain injury: a review
The prevalence of stroke and traumatic brain injury is increasing worldwide. However, current treatments do not fully cure or stop their progression, acting mostly on symptoms. Amphetamine and methylp...
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João Paulo Capela @jpcapela.bsky.social · 21/11/2024
Muitos parabéns por estale excelente programa, que muito aprecio ouvir.
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João Paulo Capela @jpcapela.bsky.social · 19/11/2024
Please add me! Thanks 🙏
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João Paulo Capela @jpcapela.bsky.social · 19/11/2024
Thanks
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João Paulo Capela @jpcapela.bsky.social · 19/11/2024
Thanks 🙏🤗
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João Paulo Capela @jpcapela.bsky.social · 19/11/2024
Hi! Can you place me in the starter pack Pharmacy and Pharmacology? Thanks
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João Paulo Capela @jpcapela.bsky.social · 19/11/2024
🧪
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João Paulo Capela @jpcapela.bsky.social · 18/11/2024
And I’m telling students to be careful about AI generated content! It seems people like more AI generated poetry…🫣🧪 www.nature.com/articles/s41...
nature.com
AI-generated poetry is indistinguishable from human-written poetry and is rated more favorably - Scientific Reports
Scientific Reports - AI-generated poetry is indistinguishable from human-written poetry and is rated more favorably
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João Paulo Capela @jpcapela.bsky.social · 15/11/2024
New Open Access Journal from Springer Nature: Discover Toxicology. I'm a Section Editor and invite you to take a look and see if it fits within your research area. link.springer.com/journal/44339
link.springer.com
Discover Toxicology
Discover Toxicology is an open access journal publishing research across all aspects of toxicology and its applications in research, development and ...
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