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Jothivanan Elumalai

@jothivanan.bsky.social

10 followers 8 following 3 posts

Postdoctoral Researcher @ RIKEN BDR, Japan. Interested in DNA replication and 3D genome organization dynamics during aging.

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Jothivanan Elumalai @jothivanan.bsky.social · 27/09/2026

This work has been a long and rewarding journey. I’m grateful to my PhD supervisor, Dr. Ichiro Hiratani, and everyone in the lab for their support.

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Jothivanan Elumalai @jothivanan.bsky.social · 27/09/2026

Using single-cell genome-wide analysis, we identified previously unrecognized classes of chromosome breaks. Furthermore, we found that different break classes are predictable using genomic/epigenomic features.

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Jothivanan Elumalai @jothivanan.bsky.social · 27/09/2026

I’m happy to share my PhD thesis work, now published in Nature Communications! Article: www.nature.com/articles/s41... Press release: www.riken.jp/press/2026/2... #academicpublishing #naturecommunications #openaccess #phdresearch

Single-cell mapping of chromosome breaks identifies multiple fragile site classes with distinct DNA replication timing landscapes - Nature Communications

Common Fragile Sites are genomic regions prone to breakage. However, other fragile sites remain underexplored. Here, the authors used single-cell genomics to map replication stress-induced breaks, ide...