Intracellular Salmonella enterica uses a type III secretion system to secrete more than 30 effector proteins into host cells. Here, Newson et al. generate six mutant strains deficient in different set...

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Newson et al. show that antibiotics not only reduce Salmonella infection but also disrupt the gut microbiota, enabling relapse and transmission from tissue-lodged persister reservoirs. Relapse requires intracellular virulence factors and produces clonal populations. Microbiota transfer between hosts blocks pathogen relapse-associated blooms, revealing how the host-pathogen-microbiota axis shapes transmission.

Newson et al. show that antibiotics not only reduce Salmonella infection but also disrupt the gut microbiota, enabling relapse and transmission from tissue-lodged persister reservoirs. Relapse require...

Salmonella enterica spp. rely on translocation of effector proteins through the SPI-2 encoded type III secretion system (T3SS) to achieve pathogenesis. More than 30 effectors contribute to manipulatio...