The ribotoxic stress response is activated upon sensing of impaired translation by the MAP3 kinase ZAKα. Vind et al. demonstrate how ZAKα surveils the translation process and interacts with elongating, stalled, and collided ribosomes. ZAKα activation depends on ribosome-templated sequestration of inhibitory domains, dimerization, and activation-loop autophosphorylation in trans.

Despite a growing interest in the ribotoxic stress response (RSR), it remains unknown how the upstream p38 and JNK-activating MAP3 kinase ZAKα senses translational impairment. Combining Alphafold3 pre...

The acute skin reaction to sunburn, encompassing keratinocyte cell death, inflammation, and epidermal thickening, has traditionally been ascribed to DNA damage responses. Using a mouse model deficient...