An updated phylogeny of bats is presented, based on new genome assemblies and many ancient fossils and including all known bat families.

Fast, scalable, accurate and accessible Bayesian phylogenetics - broadinstitute/delphy

Biological processes continuously adapt in response to intervention. Unlike static predictive models, biomedical world models support action-conditioned simulations for counterfactual reasoning, inter...

A vaccination strategy using heterologous HIV Env trimers covalently coupled to liposomes for multivalent display generates cross-neutralizing HIV serum antibody responses in non-human primates, mimic...

Many important biological functions arise not from single genes but from complex interactions encoded by entire genomes. We report the first generative design of complete bacteriophage genomes using g...

Open Science is an open-source, local-first, model-agnostic AI research workbench for scientific discovery. - aipoch/open-science

Analyses of brain single-cell transcriptomes from human, mouse, lizard, lamprey and amphioxus reveal that duplicated genes (ohnologues) played a pivotal part in early vertebrate cell-type diversificat...

Global sea surface temperatures were the second-highest on record for May.

Modern humans increasingly live long enough to experience late-life consequences of genetic and molecular systems shaped by natural selection. In this Review, the authors integrate evolutionary geneti...

Posted on behalf of the Swiss National Reference Center for Emerging Viral Infections, Geneva University Hospitals and the Institute of Medical Virology, University of Zurich (Partner Laboratory Natio...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

As somatic evolution becomes directly measurable, integrating eco-evolutionary principles with high-resolution molecular data creates opportunities to anticipate and prevent disease.

Paul Ehrlich, the leading false prophet of inevitable environmental doom and author of the infamous 'The Population Bomb,' has died at age 93.

Abstract. The origin of life is one of the great mysteries of science. Of the multiple unsolved problems, the origin of the translation system (the means b

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Natural selection favors fitter variants in a population, but actual evolutionary processes may decrease fitness by mutations and genetic drift. Ho...

The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

Abstract. The possibility of complicated dynamic behavior driven by nonlinear feedbacks in dynamical systems has revolutionized science in the latter part

Highly pathogenic avian influenza (HPAI) represents a threat to animal and human health, with the ongoing H5N1 outbreak within the H5 2.3.4.4b clade being one of the largest on record. However, it rem...

The characterisation of mutational processes active in somatic and germline cells in vivo has predominantly focused on human cancers, normal tissues and model organisms. Beyond mammals, little is know...

AbstractAneuploidy is near-ubiquitous in cancer and contributes to tumor biology. However, the temporal evolutionary dynamics that select for aneuploidy remain uncharacterized. We performed longitudin...

Dead cat led to discovery, but officials stress no further spread of H5N1 has been detected

An Ebola virus glycoprotein mutant, which emerged early during the 2018–2020 epidemic, enhances viral infectivity through multiple mechanisms and may have contributed to its dominance in the outbreak.

Sid Sijbrandij's extraordinary care journey

Abstract. Prediction is frequently asserted to be the sine qua non of science, but prediction means different things to different people in different conte

Antimicrobial-resistant pathogens pose an existential threat to modern medicine, yet the evolutionary forces driving their adaptation in healthcare systems remain largely unexplored. We revealed that ...

YouTube video by The Information Bottleneck

npj Antimicrobials and Resistance - Gene copy-number features generalize better than SNPs for antimicrobial resistance prediction in Staphylococcus aureus

Why are there so many co-circulating Klebsiella pneumoniae clones? Using genomics and large-scale metabolic modelling of >7000 isolates, this study identifies structured, clone-specific metabolic spec...

A Man From the Roman Empire Diagnosed With Metastatic Cancer 1,700 Years After His Death / cancer, Headlines, OncoDaily, Oncology, Roman Empire,

Reflecting on its limitations should guide the future of virtual cell research

Spillover of influenza A viruses from animals to humans represents a threat to our health. This Perspective discusses emerging research that suggests some influenza A viruses can enter host cells via…

Vander Meersche et al. present a large-scale analysis of the AlphaFold2/AlphaFold3/ESMFold confidence index pLDDT and flexibility metrics derived from molecular dynamics (MD) simulations. While genera...