iiinova — where your digital self keeps evolving

Reposted by Joeri Bordes

KalischLab @kalischlab.bsky.social · 14/05/2025

#resilience2025 fantastic speaker line-up: Andrew Holmes, Moh Milad, Dominique de Quervain @dequervain.bsky.social, Birgit Kleim, Rose Bagot @rcbagot.bsky.social, Floris Klumpers, Patricia Molina @pmolinamolina.bsky.social, Marianne Müller, Penny Lewis, Niels Niethard @nniethard.bsky.social, ...

lir-mainz.de

Symposium 2025 | LIR Mainz - Leibniz-Institut für Resilienzforschung

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Reposted by Joeri Bordes

Max Planck Institute of Psychiatry @mpi-psychiatry.bsky.social · 21/02/2025

With a slight delay, we turned this awesome paper into a comic 😍 Sneak peek below, check out the full version here: tinyurl.com/3jajehbn @mathiasvschmidt.bsky.social @joeribordes.bsky.social #neuroskyence #scicomm #wisskomm #sciart

Title page of a comic. In a big speech bubble, we see the title of the comic: "Research news: Males and females respond differently to early life stress". Below, we see pictures of first author Joeri Bordes on the right and Research Group Leader Mathias Schmidt on the left.

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Reposted by Joeri Bordes

Stressnetwork.ch - The Swiss Stress Network @stressnetworkch.bsky.social · 19/02/2025

Congratulations to the three winners of the Junior Investigators Awards: Pegah Kassraian, @joeribordes.bsky.social, and Laura Meine! Keep up the great work! @univbordeaux.bsky.social @columbiauniversity.bsky.social #earlylifestress #memory #stress #stressnetworkch #SN2025

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Joeri Bordes @joeribordes.bsky.social · 20/12/2024

7) This work wouldn't have been possible without the contributions of the co-authors. Also a special thanks goes to the DeepLabCut development team www.mackenziemathislab.org/deeplabcut And if you would like to use DeepOF check here: deepof.readthedocs.io/en/latest/

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Joeri Bordes @joeribordes.bsky.social · 20/12/2024

6) 🌟 Conclusion: ELS impacts stress-related neurobiology differently in males & females. HPA-axis dysregulation, altered fear memory, & brain metabolism may inform sex-specific interventions for stress-related disorders. Check out the full study for details!

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Joeri Bordes @joeribordes.bsky.social · 20/12/2024

5) Brain metabolism alterations by ELS: ELS altered purine & glutamate metabolism pathways in the BLA, dHIP, & vHIP. Sex differences in these pathways might explain distinct behavioral outcomes. Linking brain metabolism to stress response is key!

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Joeri Bordes @joeribordes.bsky.social · 20/12/2024

4) 🚀 Using the open-source package DeepOF, we performed unsupervised analysis of fear behaviors. This revealed novel sex-specific patterns, in which females showed more active fear response (darting-like behavior) via explorative behaviors, that males did not show.

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Joeri Bordes @joeribordes.bsky.social · 20/12/2024

3) 🔍 Fear memory formation is altered on freezing: ELS exposure reduces freezing behavior during fear retrieval especially in males.

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Joeri Bordes @joeribordes.bsky.social · 20/12/2024

2) 🧬 We show that ELS affects HPA-axis regulation differently in males & females: Females: Persistent body weight effects & elevated baseline CORT early on Males: Altered adrenal weight & delayed recovery of HPA-axis function Sex matters in stress response!

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Joeri Bordes @joeribordes.bsky.social · 20/12/2024

1) Early life stress (ELS) increases vulnerability to stress-related disorders, such as PTSD, often with sex-specific impacts. Using a mouse model, we explored how ELS alters: - HPA-axis regulation - Fear memory acquisition & retrieval using - Brain metabolomic pathways

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Reposted by Joeri Bordes

Mathias V. Schmidt @mathiasvschmidt.bsky.social · 13/11/2024

New paper from the lab, where we show how the co-chaperone and psychiatric risk factor FKBP5 acts in CRH-expressing neurons to shape stress- sensitive social behavior. Deep phenotyping using #DLC and #DeepOF was key to unravel these effects. www.nature.com/articles/s41...

nature.com

Deep phenotyping reveals CRH and FKBP51-dependent behavioral profiles following chronic social stress exposure in male mice - Neuropsychopharmacology

Neuropsychopharmacology - Deep phenotyping reveals CRH and FKBP51-dependent behavioral profiles following chronic social stress exposure in male mice

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