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Joan Gizzio

@joanzone.bsky.social
245 followers 405 following 6 posts

structural biology, biophysics guitarist for @KulfiGirls she/her 🧬🎵🏳️‍⚧🏳️‍🌈

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Joan Gizzio @joanzone.bsky.social · 23/02/2026
All Wee1 family kinase structures in the PDB get classified as inactive, except for one PKMYT1 structure which was released a few months ago (9m6p chain BBB) & looks a LOT like our predicted-active models. I thought this was really interesting. No substrate-bound structures of these kinases yet :)
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Joan Gizzio @joanzone.bsky.social · 23/02/2026
The C-term. end of the activation loop where protein substrates bind is important. There's lots of structures where the act. loop looks "active" from afar (DFG-in+BLAminus+"extended") but closer examination shows the C-term. end would block substrates. Our new classification system addresses this.
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Joan Gizzio @joanzone.bsky.social · 23/02/2026
So proud of this work with @rolanddunbrack.bsky.social! Did a lot of new structural bioinformatics of substrate-bound kinases and came up with updated criteria for classifying structures as active. Also made active models of all 437 human catalytic kinases, available here: dunbrack.fccc.edu/kincore
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Joan Gizzio @joanzone.bsky.social · 11/02/2024
for years, microsoft's AI image detection has identified my protein structures as "spaghetti"...
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