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John Maraganore

@jmaraganore.bsky.social
443 followers 45 following 29 posts

Founding CEO of Alnylam Pharmaceuticals. RNAi therapeutics pioneer. CEO and Principal of JMM Innovations, LLC. Committed to advancing biomedical innovation to patients.

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John Maraganore @jmaraganore.bsky.social · 02/09/2025
I’m super excited to launch Corsera Health! This is another collaboration with my friend Clive Meanwell. Our vision: a world without Cardiovascular disease! www.businesswire.com/news/home/20...
businesswire.com
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John Maraganore @jmaraganore.bsky.social · 11/08/2025
www.washingtonpost.com/business/202... Basic research “is almost like the starter when you bake sourdough bread. You can’t make the bread without it.”
washingtonpost.com
Inside science labs trying to survive in the Trump era
Anastasia Khvorova’s lab at U-Mass. Chan Medical School shows how quickly the administration is dismantling an 80-year partnership that made the U.S. a scientific superpower.
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John Maraganore @jmaraganore.bsky.social · 30/05/2025
“Brain drain” of scientists could have DIRE consequences for US leadership! “Europe, Canada, and China are laying out the red carpet to attract scientists disillusioned by America’s shifting policies.” 🙏 ⁦‪Ashish Jha‬⁩ for this thoughtful piece! www.bostonglobe.com/2025/05/27/o...
bostonglobe.com
Trump policies threaten brain drain in biomedical research - The Boston Globe
Three-quarters of US-based researchers and graduate students are considering working abroad, according to a recent study.
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John Maraganore @jmaraganore.bsky.social · 27/05/2025
SO PROUD of the City Team forming their 2nd major alliance!!!! This time with Biogen for a CNS target, w/ $46M upfront and >$1B in total deal value! Combined with earlier Bausch & Lomb deal, City is growing strong in a tough tape! www.globenewswire.com/news-release...
globenewswire.com
Biogen and City Therapeutics Announce Strategic Research Collaboration to Develop Select Novel RNAi-based Therapies
Collaboration leverages City Therapeutics’ next-generation RNAi engineering technologies and Biogen’s extensive drug development expertise...
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John Maraganore @jmaraganore.bsky.social · 22/05/2025
I’m all for real “MAHA!” Everyone should be! Here are some real ideas from experts. www.statnews.com/2025/05/21/r...
statnews.com
Three big ideas to actually ‘Make America Healthy Again’
STAT reviewed dozens of studies, interviewed chronic disease experts, and landed on three focus areas for Robert F. Kennedy Jr. to boost health.
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John Maraganore @jmaraganore.bsky.social · 22/05/2025
“The report also raises concerns about… children and their prescription drug use, including antibiotics and medications used to treat attention deficit disorders. So, where’s the “gold-standard science” supporting these and other purported concerns? www.bostonglobe.com/2025/05/22/n...
bostonglobe.com
RFK Jr.’s MAHA report raises concerns about vaccines, American foods and prescription drugs - The Boston Globe
The report will be used over the next 100 days for the MAHA commission to fashion a plan that can be implemented during the remainder of President Trump’s term.
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John Maraganore @jmaraganore.bsky.social · 30/04/2025
“Proposed funding cuts, the firing of essential federal scientists, and policy uncertainties threaten to undermine the foundation for our nation’s global leadership,” Collins said. I could not agree more!
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John Maraganore @jmaraganore.bsky.social · 15/04/2025
IMO… Bigger risks to KSQ are: - Capital markets, made worse by uncertainty of destabilized FDA and tariffs - Attack on academic institutions and science - “Hybrid” work, with fewer people interacting in KSQ www.bostonglobe.com/2025/04/14/b...
bostonglobe.com
‘I think it is actively happening’: Is Boston’s biotech industry doomed? - The Boston Globe
With a "terrible" job market, empty labs, and mounting competition from China, the lifeblood of Kendall Square is under massive threat.
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John Maraganore @jmaraganore.bsky.social · 09/04/2025
We must preserve our U.S. leadership in science and medicine! Also supported by economic grounds alone…. “History shows that science reliably generates immense economic benefit.” www.cnn.com/2025/04/09/h...
cnn.com
Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN
Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...
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John Maraganore @jmaraganore.bsky.social · 09/04/2025
Some strategy tips for biotech CEOs in this brutal environment from a convo with ⁦‪@AndrewE_Dunn‬⁩ from ⁦‪@endpts‬⁩. My favorite tip (not covered as much in article) is to be hyper focused on what moves the needle for patients, and then investors. endpts.com/biotech-mark...
endpts.com
Market turmoil is tanking biotech M&A and IPOs. Here's the playbook startups will use to survive
It’s a biotech environment without many good choices. Even before President Donald Trump’s tariff announcement pushed stock indices toward a bear market, biotech M&A has been virtually nonexistent, wi...
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John Maraganore @jmaraganore.bsky.social · 02/04/2025
GO VACCINES! www.nytimes.com/2025/04/02/h...
nytimes.com
Shingles Vaccine Can Decrease Risk of Dementia, Study Finds
A growing body of research suggests that preventing the viral infection can help stave off cognitive decline.
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John Maraganore @jmaraganore.bsky.social · 02/04/2025
New company aiming to transform health… Exciting times ahead!
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Reposted by John Maraganore
Matthew Herper @matthewherper.bsky.social · 31/03/2025
It’s RFK Jr.’s FDA now My take on Peter Marks' ouster -- and why you don't have to think Marks is a hero to be worried about what it means. www.statnews.com/2025/03/31/r...
statnews.com
It’s RFK Jr.’s FDA now
Why the ouster of Peter Marks, a senior FDA official, is a huge deal, whether you liked him or not.
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John Maraganore @jmaraganore.bsky.social · 30/03/2025
“I hope Marty comes understanding magnitude of his responsibility and builds back FDA that is based on science and being gold-standard regulatory authority of the world.”
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John Maraganore @jmaraganore.bsky.social · 30/03/2025
www.statnews.com/2025/03/29/f... Makary has “unprecedented opportunity and enormous responsibility to rebuild FDA.” “never seen this large of a set of openings under one commissioner,”
statnews.com
Ouster of FDA’s Peter Marks alarms a biopharma industry that saw him as an ally
Will Peter Marks' ouster from the FDA change how pharma industry engages with the Trump administration?
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John Maraganore @jmaraganore.bsky.social · 29/03/2025
www.wsj.com/politics/top... “It has become clear that truth and transparency are not desired by the Secretary, but rather he wishes subservient confirmation of his misinformation and lies”
wsj.com
Exclusive | Top Vaccine Official Out at FDA
In his resignation letter, Dr. Peter Marks cited ‘misinformation and lies’ from Health and Human Services Secretary RFK Jr.
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John Maraganore @jmaraganore.bsky.social · 28/03/2025
www.nature.com/articles/d41... We must attract and RETAIN the greatest and best scientists in the world if the US is going to be “Great Again!”
nature.com
75% of US scientists who answered Nature poll consider leaving
More than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.
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John Maraganore @jmaraganore.bsky.social · 17/03/2025
Important oped by ⁦‪@DrSidMukherjee‬⁩…. “we seem to be turning away from the idea that health is a collective endeavor, a public good at all, and retreating into the rhetoric of personal responsibility.” Fully share this concern as our public health apparatus is being dismantled!
nytimes.com
Opinion | Covid’s Deadliest Effect Took Five Years to Appear
What once belonged to all of us now belongs to corporations.
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John Maraganore @jmaraganore.bsky.social · 15/03/2025
We lead the world in science and medicine for patients! A big part of this is our vibrant biotechnology industry… But our leadership requires strong and well funded basic research at the @NIH!
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John Maraganore @jmaraganore.bsky.social · 07/03/2025
Completely avoidable.
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John Maraganore @jmaraganore.bsky.social · 24/02/2025
Why. We. Do. What. We. Do! Bravo ⁦‪@Regeneron‬⁩!
fiercebiotech.com
Regeneron gene therapy improves hearing in 10 children with rare form of hearing loss
Regeneron’s investigational gene therapy has been tied to | Regeneron’s investigational gene therapy has been tied to notable hearing improvements in 10 of 11 children who were treated for a rare gene...
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John Maraganore @jmaraganore.bsky.social · 06/02/2025
Same story, 14 years and one day later. For the sake of patients, let’s hope for the same outcome! Keep going, CRISPR folk!
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John Maraganore @jmaraganore.bsky.social · 27/01/2025
News like this makes my day… - Great clinical data with profound impact for patients in high unmet need indication - Market responds positively rewarding investors A reminder that this is how biotech should work!
statnews.com
Akero drug reverses liver scarring in study of severe MASH patients
Akero reported Monday strong results showing its drug efruxifermin reversed liver scarring in patients with cirrhosis caused by a disease known as MASH.
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John Maraganore @jmaraganore.bsky.social · 15/01/2025
So fun to unite with ALumNY at JPM. It’s so important to stay close with former colleagues in next chapters. Sometimes you end up working together again (as is the case with many here)!
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John Maraganore @jmaraganore.bsky.social · 14/01/2025
This is great! FDA modernization grounded in science and evidence would be welcome!
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John Maraganore @jmaraganore.bsky.social · 30/12/2024
Terrific way to close out 2024 with a round up of medical advances. Thanks ⁦‪@matthewherper‬⁩! - 50 FDA approvals - Impressive roster of new medicines and data - Despite lingering and tough capital markets, science prevails Happy New Year to all!
statnews.com
The biggest medical advances of 2024
The biggest medical advances of 2024 will be remembered as significant long into the future.
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John Maraganore @jmaraganore.bsky.social · 24/12/2024
My personal favorite: “Vutrisiran in patients with transthyretin mediated cardiomyopathy”!
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John Maraganore @jmaraganore.bsky.social · 09/12/2024
Found my seat at the airport! 🤣🤣🤣
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John Maraganore @jmaraganore.bsky.social · 08/12/2024
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