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Joshua Mcbee

@jkmcbee.bsky.social
496 followers 958 following 106 posts

LCMS weirdo. Pretend expert in all things charged or separated. Biking aficionado, coffee enthusiast, destroyer of mass spectrometers.

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Joshua Mcbee @jkmcbee.bsky.social · 15/09/2026
Meh. His first album was better.
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Joshua Mcbee @jkmcbee.bsky.social · 03/12/2025
Not a miscommunication but I saw a tray of urine specimens at a state forensic tox lab shatter all over the floor as it came out of the evidence room. I still shudder at the number of cases that likely got disrupted from that accident.
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Joshua Mcbee @jkmcbee.bsky.social · 25/11/2025
Great shot! Where did you take this picture? It reminds me of some of the lava tubes we used to explore in and around the bend Oregon area when I was younger.
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Joshua Mcbee @jkmcbee.bsky.social · 11/09/2025
I think they just created a big box o’ ions that they can eject when they are ready.
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Joshua Mcbee @jkmcbee.bsky.social · 04/09/2025
Perhaps it’s time we hold the stir bar stationary and rotate the reaction flask instead?
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Joshua Mcbee @jkmcbee.bsky.social · 16/08/2025
We don’t know what the risk of this modification is but we tested Ozempic as well and it was well within the guidelines of manufacturing peptide drugs. Beware of these pharmacies offering “cheap” GLP-1s. You don’t always know what You are going to get. www.linkedin.com/posts/joshua...
linkedin.com
If you have a prescription for Ozempic, its tempting to save money by buying Semaglutide from a compounding pharmacy, but you should know the risks. | Josh McBee, M.S., Ph.D.
If you have a prescription for Ozempic, its tempting to save money by buying Semaglutide from a compounding pharmacy, but you should know the risks. Recently we demonstrated a rapid LCMS assay using ...
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Joshua Mcbee @jkmcbee.bsky.social · 16/08/2025
Semaglutide as well. With the explosion of compounding GLP-1s we wanted to see if improper handling would create this modification. We “obtained” a syringe of compounded Semaglutide and sure enough the modification shows up at about 1.5% relative to the FLP which exceeds FDA guidelines.
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Joshua Mcbee @jkmcbee.bsky.social · 16/08/2025
Was sensitive to formaldehyde and could cyclize and this was noticed with interaction to certain excipients. We developed a quick assay for monitoring this modification. But we wanted to see if Semaglutide was sensitive to this modification too. Sure enough, exposure to formaldehyde modified
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Joshua Mcbee @jkmcbee.bsky.social · 16/08/2025
Here’s an interesting story for #teammassspec. Liraglutide went generic in December 2024 and we have been developing methods for impurity characterization but we kept seeing an unusual modification with a +12 Da shift. A little digging revealed that others had noticed that the n-terminal histidine..
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Joshua Mcbee @jkmcbee.bsky.social · 14/07/2025
Is the report $2500?
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Joshua Mcbee @jkmcbee.bsky.social · 09/07/2025
Perhaps a bit too obscure… The Dune “Oh hai Duncan!”
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Joshua Mcbee @jkmcbee.bsky.social · 20/06/2025
Delaware pickleball is vicious man.
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Joshua Mcbee @jkmcbee.bsky.social · 06/06/2025
That’s a big field.
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Joshua Mcbee @jkmcbee.bsky.social · 01/06/2025
Dinner at Locust Point Steamers in Baltimore prior to #ASMS2025. Highly recommended for any seafood lovers coming to the conference!
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Joshua Mcbee @jkmcbee.bsky.social · 28/05/2025
“The gorillas will freeze to death in the winter!”
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Joshua Mcbee @jkmcbee.bsky.social · 27/05/2025
I feel like time of flight is a valid approach here. Maybe a bunch of trampolines for multi reflectron.
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Joshua Mcbee @jkmcbee.bsky.social · 21/05/2025
The progress in drugs for treating cardiovascular disease over the last 5 years alone is remarkable. Drugs like Repatha and Leqvio virtually halt plaque deposition. The current guidelines for someone with CVD are to have your LDL-C below your HDL.
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Joshua Mcbee @jkmcbee.bsky.social · 18/05/2025
Many of the original Stephen King adaptations Firestarter Christine The Dead zone And Cujo scared the bejesus out of me as a kid
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Joshua Mcbee @jkmcbee.bsky.social · 18/05/2025
Also Prince of Darkness is pretty solid 80’s horror
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Joshua Mcbee @jkmcbee.bsky.social · 18/05/2025
Was thinking the original Cronenberg.
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Joshua Mcbee @jkmcbee.bsky.social · 18/05/2025
Dead Ringers?
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Joshua Mcbee @jkmcbee.bsky.social · 12/05/2025
“It takes two to lie Marge, one to lie and one to listen!”
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Joshua Mcbee @jkmcbee.bsky.social · 07/05/2025
Achieve mystical levels of proteome coverage!
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Joshua Mcbee @jkmcbee.bsky.social · 07/05/2025
Putting in a vote for Orbitrap Astral Plane…
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Joshua Mcbee @jkmcbee.bsky.social · 05/05/2025
Catch-44
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Joshua Mcbee @jkmcbee.bsky.social · 05/05/2025
Two fistfuls of Dollars.
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Joshua Mcbee @jkmcbee.bsky.social · 05/05/2025
4020: the year we made contact…and charged them for it.
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Joshua Mcbee @jkmcbee.bsky.social · 26/04/2025
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Joshua Mcbee @jkmcbee.bsky.social · 23/04/2025
I noticed the LECO patent expired last year as well…
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Joshua Mcbee @jkmcbee.bsky.social · 23/04/2025
More likely that Thermo filed it as a “non-obvious” improvement of existing IP which is a bit of a grey area In patents but allowable If you look at Mobilion patents they filed something similar using a 2 dimensional traveling wave as a pre-filter on PCB boards patents.google.com/patent/US122...
patents.google.com
US12228546B2 - Mobility based filtering of ions - Google Patents
In one implementation, a mobility-based ion separation system includes a first ion channel extending between a first end and a second end, and configured to receive an ion packet. The separation syste...
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Joshua Mcbee @jkmcbee.bsky.social · 23/04/2025
Waters has increasingly been reliant on selling consumables and services rather than instrument sales. Their r&d spend is less than the other companies and IMO they suffer from a lack of diversification so if the LCMS business is in a lull, the whole company is hurting. It puts them in a tough spot.
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Joshua Mcbee @jkmcbee.bsky.social · 23/04/2025
They have still been hampered by others IP. The Astral, if I recall, uses stacked ADC chips which until recently was owned by Agilent but I think the pate t recently expired. I do know the Astral uses the Acquiris 14-bit ADC in dual Channel mode.
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Joshua Mcbee @jkmcbee.bsky.social · 23/04/2025
The mrTOF is a LECO patent licensed by both companies. Also, the success of the Orbi has allowed Thermo to spend multitudes more than the other companies on HRMS. That combined with being part of a large diverse company gives them lots of resources to find “improved” ways to implement a technology.
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Joshua Mcbee @jkmcbee.bsky.social · 19/04/2025
A recommend against it. I went with my kids once about 10 years ago and left With a torn labrum in my right hip. That was my first real reality check that I was getting old.
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Reposted by Joshua Mcbee
George Conway ⚖️🇺🇸 @gtconway.bsky.social · 06/04/2025
This is perfect. Absolutely perfect.
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Joshua Mcbee @jkmcbee.bsky.social · 04/04/2025
My alma mater as well. I miss the campus and Seattle in the spring very much.
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Joshua Mcbee @jkmcbee.bsky.social · 02/04/2025
You forgot my personal favorite of his: Real Genius.
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Joshua Mcbee @jkmcbee.bsky.social · 01/04/2025
Cory Booker on the floor of the senate reconciling quantum mechanics and relativity.
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Joshua Mcbee @jkmcbee.bsky.social · 31/03/2025
It’s like a Cybertruck for your feet!
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Joshua Mcbee @jkmcbee.bsky.social · 08/03/2025
DDM was critical for determining the first GPCR crystal structure, Rhodopsin. It’s a great mild detergent.
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Joshua Mcbee @jkmcbee.bsky.social · 02/03/2025
Man and they were so close to finishing the game.
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Joshua Mcbee @jkmcbee.bsky.social · 23/02/2025
I can also highly recommend Herschel’s Deli. Get the Reuben.
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Joshua Mcbee @jkmcbee.bsky.social · 21/02/2025
I am going to #USHUPO2025 next week. I’m super excited to connect with some old friends and have some conversations with everyone about all the latest tech! If you see me there, please tap me on the shoulder and say hello!
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Joshua Mcbee @jkmcbee.bsky.social · 31/01/2025
I mean the lord of the rings movies are pretty close to 4 years long…
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Joshua Mcbee @jkmcbee.bsky.social · 13/01/2025
Tuning a quadrupole with dials.
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Joshua Mcbee @jkmcbee.bsky.social · 06/01/2025
Never trust the trunk vaccine…. This guy was openly advertising on Facebook and I had to privately advise friends not to take it. I eventually handed everything I had over to the AG’s office.
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Joshua Mcbee @jkmcbee.bsky.social · 06/01/2025
I can top that. I knew a guy that got busted handing out bogus Covid shots at $400 a pop. I turned down the offer. www.justice.gov/usao-wdwa/pr...
justice.gov
Purveyor of fake COVID-19 vaccines sentenced
Seattle – A Redmond, Washington, man who held himself out as a biotech expert was sentenced today in federal court for introducing misbranded drugs into interstate commerce, announced U.S. Attorney Ni...
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Joshua Mcbee @jkmcbee.bsky.social · 03/01/2025
Live dangerously, in 2025 have two!
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Joshua Mcbee @jkmcbee.bsky.social · 31/12/2024
Late nite tamales are the best tamales.
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Joshua Mcbee @jkmcbee.bsky.social · 31/12/2024
I believe the Romans used to pay soldier wages with followers.
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