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Jiadong Mao

@jiadongm.bsky.social
62 followers 108 following 41 posts

Computational biologist | Single-cell and spatial omics | Multiomics integration | mixOmics team Interested in history of ideas. Current reading project: understanding how modern synthesis came about.

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Jiadong Mao @jiadongm.bsky.social · 26/05/2026
Latest blog post on Copernicus and moth 😃 jiadongm.github.io/blog/posts/C...
jiadongm.github.io
Heliocentrism and mimicry: why revolutionary ideas seem dumb at the start – Jiadong Mao
Why good scientific ideas can initially look technically unconvincing.
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Jiadong Mao @jiadongm.bsky.social · 14/04/2026
Heard about Fisher's attidude towards post-mortem statistical analysis before. But this is still very fun to read: 'Biological workers were shy of mathematics and certainly to begin with felt that the statistician should only be called in after the data had been collected.' (from Fisher's biography)
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MIG @mig-unimelb.bsky.social · 30/03/2026
📢 MIG Workshop: Single cell RNA-seq analysis 🗓️ Thu, Apr 16 | ⏰ 9:30 am - 12:00 pm AEDT 📍 Zoom (registered participants only) 🎙️ Xiaochen Zhang 💰 $25 (fully refunded upon attendance) #scRNAseq #Bioinformatics #Rstats #Genomics
events.unimelb.edu.au
MIG Workshop: Single cell RNA-seq analysis
About the Event This workshop will give you the necessary foundations to get started with single cell RNA-seq analysis, using the R programming...
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Jiadong Mao @jiadongm.bsky.social · 27/03/2026
Very cool idea, might be useful to help players with hearing problems to play in an ensemble? www.science.org/doi/10.1126/...
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Jiadong Mao @jiadongm.bsky.social · 18/03/2026
Great work! Congratulations Team.
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Cancer Bioinformatics Australia @cancerbioinfoau.bsky.social · 13/02/2026
📣 Registrations and Abstract submissions are now open for Cancer Bioinformatics Australia 2026! Symposium Info: cancerbioinformatics.au Registrations (closes May 22nd): cancerbioinformatics.au/register Abstract submission (closes March 27th): cancerbioinformatics.au/abstracts
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Jiadong Mao @jiadongm.bsky.social · 20/01/2026
My Year 1 daughter thinks my job is a combination of what she learns from ICT, science and art classes. A clever summary. Here is a plot of spatial cell niches on a lung cancer slide she drew 😆
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Jiadong Mao @jiadongm.bsky.social · 15/01/2026
Have a look at new software paper on integrating >=3 omics using DIVAS. DIVAS is a unique method that finds jointly shared, partially shared and individual variations in multiomics data. If you've heard of JIVE: this is the newest generation from the same lineage. www.biorxiv.org/content/10.6...
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Jiadong Mao @jiadongm.bsky.social · 05/12/2025
Great to have Prof Shihua Zhang from Chinese Academy of Science. A humble person passionate about science. Impressed by their tools for spatial omics. Had a delightful evening talking to him. We agree that there should be more occasions like this in the coming year 👍🏻
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Jiadong Mao @jiadongm.bsky.social · 28/11/2025
E B Ford told us one of his colleagues lamented that today's knowledge is but tomorrow's error. Another colleaugue corrected the former, saying that today's knowledge is tomorrow's special case. This is a wonderful scientific version of the 'is the class half empty or half full' expression.
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Jiadong Mao @jiadongm.bsky.social · 28/11/2025
Melbourne airport T1 is evacuated because of 🔥alarm. We’re the 13th flight queuing to enter the airport … Dramatic ending of #ABACBS2025 for Melbournians 😫
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Jiadong Mao @jiadongm.bsky.social · 28/11/2025
Took the opportunity to visit Darwin’s greatest student 😃 Besides, if you’re interested in old buildings, St Peter’s Cathedral in Adelaide is definitely worth visiting
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Jiadong Mao @jiadongm.bsky.social · 27/11/2025
We need more conference front line reporters like @sagrikachugh.bsky.social and @jovmaksimovic.bsky.social 😄 Didn’t attend the conference but felt I did
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Jiadong Mao @jiadongm.bsky.social · 26/11/2025
The diffusion of CellDiffusion is non stoppable 😄
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Jiadong Mao @jiadongm.bsky.social · 26/11/2025
Another reason to plan a Brisbane trip in 2026
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Jiadong Mao @jiadongm.bsky.social · 26/11/2025
Got these for $30. The smaller one is a concise version of the larger. Ford is a key figure in modern synthesis. He reviewed field observations for his theory on supergene and polymorphism. Ford’s dense style reminded me of his close ally RA Fisher, both in denial of the importance of genetic drift
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Jiadong Mao @jiadongm.bsky.social · 25/11/2025
Galton’s Hereditary Genius, a reprint of 2nd ed. First book to use the term eugenics. Galton’s cousin Darwin respected his abilities, citing Galton’s work in eg The Descent of Man. Darwin seems to have been unenthusiastic about eugenics, sparing him from having his reputation ruined a century later
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MIG @mig-unimelb.bsky.social · 28/10/2025
📢 MIG Seminar: End-to-end spatial transcriptomics analysis with VR-Omics 🗓️ Fri, Oct 31 | ⏰ 12 - 1 pm AEST 📍 Agar Theatre (G003), Biosciences 4 (147) 🎙️ Prof. Mirana Ramialison (Murdoch Children’s Research Institute) 🧍‍♂️In-person only #MultisliceDatasets #DataVisualization #VirtualReality
events.unimelb.edu.au
MIG Seminar: Prof. Mirana Ramialison, Murdoch Children’s Research Institute
Title: End-to-end spatial transcriptomics analysis with VR-Omics Abstract The field of spatial transcriptomics (ST) is progressing rap...
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Jiadong Mao @jiadongm.bsky.social · 26/09/2025
We’ll have a shorter version of our Spatial Transcriptomics workshop at ABACBS as part of the BiocAisa stream. See you in Nov in Adelaide 😃 blackochrelabs.au/abacbs2025_w...
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Matt Golding @goldingcartoons.bsky.social · 01/09/2025
I find it disrespectful when people, such as Pauline Hanson, wrap themselves in our flag and treat it as a cheap theatrical prop to push their political agenda. Anne Maki, Alphington @theage letters
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Jiadong Mao @jiadongm.bsky.social · 16/08/2025
Habits taught physicists to look for elegant laws in biology. But biology’s only rule is: whatever works. Whatever that works, regardless how inelegant, will be embedded in organisms via evolution. This reminds me of the recent Themis to Workday mayhem at unimelb. Don’t change what already works!
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Jiadong Mao @jiadongm.bsky.social · 16/08/2025
A very successful workshop on spatial transcriptomics! Great fun working with @bhuvad.bsky.social & Melody Jin. The audience were most engaged 🥰 Out materials covers QC, normalisation, cell states annotation, niche identification and differential genes in ST data: bhuvad.github.io/CosMxSpatial...
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Kim-Anh Lê Cao @mixomics.org · 31/07/2025
Very very excited to have mixOmics shortlisted as a finalist! 🥳 A great recognition of our contribution to research software in #Rstats @mig-unimelb.bsky.social
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Kim-Anh Lê Cao @mixomics.org · 23/07/2025
Amazing opportunity to work at the cutting edge of statistics and omics with us at Melbourne Integrative Genomics @mig-unimelb.bsky.social, University of Melbourne. Closes: 29th August. Contact: Prof Kim-Anh Le Cao (director of MIG) Junior to mid career level Apply here: tinyurl.com/yu97nrws
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Jiadong Mao @jiadongm.bsky.social · 14/07/2025
Great to be part of the ambitious project to marry metabolism and lineage tracing in cancer 😃
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Jiadong Mao @jiadongm.bsky.social · 03/07/2025
Come and join national experts and local colleagues learning spatial transcriptomics data analysis 😃 I expect a lot of inspiring conversations and mutual learning.
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Jiadong Mao @jiadongm.bsky.social · 16/06/2025
First time giving talk in a chapel(-like venue)
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Jiadong Mao @jiadongm.bsky.social · 06/06/2025
Great to have talked about PhiSpace at WEHI. I think we have the coolest team member photos.
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Jiadong Mao @jiadongm.bsky.social · 29/05/2025
PhiSpace has 7 case vignettes now, covering bulk RNA-seq, single-cell multiomics and spatial RNA-seq. Particularly surprised by the performance of PhiSpace when applied to quantify T cell state changes caused by genetic perturbations. jiadongm.github.io/PhiSpace/art...
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Jiadong Mao @jiadongm.bsky.social · 24/05/2025
A new test for LLM? 😂 Seems that the newest Claude 4.0 has no clue about violin finguring. It says the openning bar of violin part here is played using 1st position, but it should be 3rd. I tried a few pieces. Seems that Claude has no difficulty understanding other aspects but finguring
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Dr Shane Huntington OAM @drshanerrr.bsky.social · 23/05/2025
It continues….. www.theguardian.com/us-news/2025...
theguardian.com
Trump administration halts Harvard’s ability to enroll international students
Homeland security secretary Kristi Noem posts copy of department’s letter to university on X
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Jiadong Mao @jiadongm.bsky.social · 22/05/2025
MIG has an official linkedin account now! It's time to follow it (we need just five more followers before start posting exciting content 😂) www.linkedin.com/company/melb...
linkedin.com
LinkedIn Login, Sign in | LinkedIn
Login to LinkedIn to keep in touch with people you know, share ideas, and build your career.
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Jiadong Mao @jiadongm.bsky.social · 20/05/2025
When Menzies founded the liberal party a big part of their support actually came from women and first home buyers. A Stark contrast.
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Jiadong Mao @jiadongm.bsky.social · 20/05/2025
Program for Cold Spring Harbour Symposia on Quantitative Biology 1947: nucleic acids and nucleoproteins. Two talks a day!
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Jiadong Mao @jiadongm.bsky.social · 19/05/2025
In Fisher’s textbook, experimental design is an integral part of stats. For example, he said correlation is often for observations which we cannot control (eg human height). When there are controlled experiments, correlation is seldom needed: we need regression and hypothesis testing instead
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Harvard T.H. Chan School of Public Health @hsph.harvard.edu · 16/05/2025
With nearly all of Harvard Chan School’s direct federal grants terminated, we are relying on philanthropy to power our research and support our educational programs. Every gift, regardless of size, advances our vision of health, dignity, and justice for every human. Support our work: hsph.me/whygive
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Mark Dawson @mafdawson.bsky.social · 15/05/2025
Australia completely lacks a dedicated training program for clinician scientists. With the vision and support of VMIAL @petermaccc.bsky.social is extremely proud to announce the first clinician-scientist fellowship. If you meet the eligibility criteria PLEASE APPLY! www.nature.com/naturecareer...
nature.com
Clinician Scientist Fellowship - Parkville, Melbourne (AU) job with Peter MacCallum Cancer Centre – Parkville | 12839522
Peter Mac is launching Australia’s first clinician-scientist fellowship to advance cancer care, fostering innovation and global collaboration.
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Jiadong Mao @jiadongm.bsky.social · 13/05/2025
Fisher (1936): each generation has found in Mendel’s work what they expected to find, ignored what did not conform to their theory - the first generation (Mendel’s contemporaries) thought it’s just another paper on hybridisation; the second thought it’s incompatible with continuous evolution.
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Millennium Science @mscience.bsky.social · 13/05/2025
Join the conversation this FRIDAY for Cellular Conversations with @jovmaksimovic.bsky.social , "More biology without (that much) extra effort – using custom probes with 10x Flex to detect cancer fusion transcripts." www.mscience.com.au/event/cellular-conversations-with-dr-jovana-maksimovic/
mscience.com.au
Cellular Conversations with Dr Jovana Maksimovic
More biology without (that much) extra effort – using custom probes with 10x Flex to detect cancer fusion transcripts Register to attend Gene fusions are caused by chromosomal rearrangements such as t...
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Jiadong Mao @jiadongm.bsky.social · 01/05/2025
Seems that geneticists realised very early on (soon after the ‘rediscovery’ of Mendel in 1900) that Mendel’s data collection violated some fundamental principles of statistical experimental design. This led to Fisher’s famous criticism of Mendel’s results as ‘too good to be true’.
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Ossoff's Office @ossoff.senate.gov · 30/04/2025
Sen. Ossoff: Who out there in the American public is sitting at home demanding that we shut down cancer research and Alzheimer's research?
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Jiadong Mao @jiadongm.bsky.social · 24/04/2025
Exam papers of UniMelb in 1891, not a single question in biology exams was about Darwinism. This reflects a period which Julian Huxley referred to a ‘the eclipse of Darwinism’, ie late 19th early 20th century when Darwinism was seriously challenged and went into oblivion.
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Jiadong Mao @jiadongm.bsky.social · 24/04/2025
First saw Cajal's drawings in Mukherjee's recent book The Song of the Cell, and was immediately amazed by his artistic talent (and patience!) in drawing neurons
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Jiadong Mao @jiadongm.bsky.social · 11/04/2025
in some hospitals tube feed is almost default for head and neck cancer patients experiencing chemo. Another common cause of swallowing difficulty is mucositis, an inflammation and ulceration of the mucous membrane
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Jiadong Mao @jiadongm.bsky.social · 10/04/2025
We built a comprehensive cell atlas of human neutrophils across all maturation stages. Compared to single-neutrophil RNA-seq datasets, our bulk atlas is multiomic and has more refined and reliable cell state labels. PhiSpace was used to query external data. www.researchsquare.com/article/rs-6...
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WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · 09/04/2025
Could this breakthrough research lead to the first treatment for #longCOVID? A world-first milestone made possible through the advanced technologies of the National Drug Discovery Centre. Find out more: www.wehi.edu.au/news/tacklin...
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Jiadong Mao @jiadongm.bsky.social · 04/04/2025
Quite amazing
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Dr. Jean Fan @jef.works · 03/04/2025
We identify evidence of off-target probe binding in the 10x Genomics #Xenium v1 Human Breast Gene Expression Panel, compromising the accuracy of resulting #singlecell #spatialtranscriptomics profiles See our preprint for more details: www.biorxiv.org/content/10.1... #AcademicSky 🧵👇 1/n
biorxiv.org
Evidence of off-target probe binding in the 10x Genomics Xenium v1 Human Breast Gene Expression Panel compromises accuracy of spatial transcriptomic profiling
The accuracy of spatial gene expression profiles generated by probe-based in situ spatially-resolved transcriptomic technologies depends on the specificity with which probes bind to their intended tar...
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Jiadong Mao @jiadongm.bsky.social · 02/04/2025
Discovery of DNA as the material basis of gene is a synthesis of molecular biology and information theory/cybernetics: many biologits couldn't imagine how a 'boring' molecule like DNA can be the basis of heredity. The paradigm shift relies partially on the popularity of 'information' and 'code'.
Matthew Cobb, Life's Greatest Secret
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Jiadong Mao @jiadongm.bsky.social · 02/04/2025
NNet can discover of fine-grained gene regulatory networks (GRNs) in scRNA-seq data, eg GRNs of a transitional cell state. A natural complement to PhiSpace! We can use PhiSpace for cell state discovery and then use NNet to uncover gene regulation in cell states of interest 🤔😃
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