Jacques Fattaccioli @jfattaccioli.bsky.social · 15/07/2026Let's go back to that paper: what Curtis actually argued, why the physics was unusual for a zoologist, and how the technique travelled from a cell biology dispute to quantitative colloidal force spectroscopy over sixty years. 020
Jacques Fattaccioli @jfattaccioli.bsky.social · 15/07/2026The technique he invented, which he quietly called "interference reflection microscopy," became one of the workhorses of adhesion biophysics. 120
Jacques Fattaccioli @jfattaccioli.bsky.social · 15/07/2026In 1964, a zoologist at UCL shone a mercury lamp through a glass slide and measured — for the first time, in living cells — the gap between a cell membrane and a substrate. No fluorescent labels. Just interference fringes. 👉 jfattaccioli.substack.com/p/2-1964-one...jfattaccioli.substack.com#2 — 1964: One gap, one fringeHow a zoology paper invented a technique it didn't know it was inventing 182
Reposted by Jacques FattaccioliManuel Thery @manuelthery.bsky.social · 21/05/2026Interdisciplinary course on Artificial Cells next fall in Paris. Registrations are open : www.edu.bio.ens.psl.eu/spip.php?art... For masters, PhD students and postdocs. Every wednesday, 5 to 7 PM, @espciparispsl.bsky.social from September to December. See below for the list of great teachers! 171912
Jacques Fattaccioli @jfattaccioli.bsky.social · 16/04/2026Arrived today. From the father of Damon Albarn. Maths / Geometry / Islamic architecture and a tiny bit of 70's mysticism 120
Jacques Fattaccioli @jfattaccioli.bsky.social · 20/03/2026www.pharmaceutical-technology.com/news/quintes...pharmaceutical-technology.comQuintessence debuts first 'living' artificial cell for CGT bio-separation - Pharmaceutical TechnologyQuintessence's technology is designed to simplify the bio-separation process in CGT manufacturing while reducing production costs. 011
Jacques Fattaccioli @jfattaccioli.bsky.social · 09/03/2026We are welcoming Marie S. Curie Postdoctoral Fellowships #msca with Sorbonne Université: www.sorbonne-universite.fr/en/news/msca... Our two proposals : www.sorbonne-universite.fr/sites/defaul... www.sorbonne-universite.fr/sites/defaul... Feel free to contact us (dm or email) for details.sorbonne-universite.frMSCA Postdoctoral Fellowships 2026Sorbonne University provides an attractive support mechanism to strengthen Marie Skłodowska Curie Postdoctoral Fellowships projects. 012
Jacques Fattaccioli @jfattaccioli.bsky.social · 25/01/2026@museeorsay.bsky.social @manuelthery.bsky.social 051
Jacques Fattaccioli @jfattaccioli.bsky.social · 22/01/2026@espciparispsl.bsky.social a nice view from rue Vauquelin ! 091
Jacques Fattaccioli @jfattaccioli.bsky.social · 31/12/2025Wet Leg ça envoie. A l'Olympia c était top il y a quelques semaines. 010
Jacques Fattaccioli @jfattaccioli.bsky.social · 14/12/2025Je suis allé voir Primal Scream au printemps c était la maison de retraite... 010
Jacques Fattaccioli @jfattaccioli.bsky.social · 11/12/2025Today Estelle LU from our team defended her PhD thesis on the "Microfluidic Fabrication and Characterization of AESO microparticules" in front of P. Joseph (LAAS), V. Schmitt (CRPP) and R. Bongiovanni (Politechnico Torino). Congratulations Dr Lu ! 010
Reposted by Jacques FattaccioliFlorence Niedergang @florenceniedergang.bsky.social · 08/12/2025Happy to share that I will be presenting at #CellBio2025 this afternoon during the #CSCB session in room 108 our work on #phagocytosis by #macrophages mannose receptor done @institutcochin.bsky.social by @chiarapompili.bsky.social with @jfattaccioli.bsky.social and @jean-Maurice Mallet 094
Reposted by Jacques FattaccioliManuel Thery @manuelthery.bsky.social · 05/12/2025#LivingArchitectures We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay. www.musee-orsay.fr/fr/agenda/ev... Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night. -> Two shows on the 24th and 25th of January. 19312103
Reposted by Jacques FattaccioliBiophysical Paris @parisseminar.bsky.social · 01/12/2025www.icbp2026.org 12013
Reposted by Jacques FattaccioliUniversité PSL @psl-univ.bsky.social · 21/11/2025@college-de-france.fr @institutcurie.bsky.social @normalesup.bsky.social @obs-paris-psl.bsky.social @minesparis-psl.bsky.social @univdauphine.bsky.social @ecoledeschartes.bsky.social @espciparispsl.bsky.social @ephe-psl.bsky.social 011
Jacques Fattaccioli @jfattaccioli.bsky.social · 20/11/2025Inside macrophages, the particles report the onset and progression of phagosomal acidification at single-object resolution. This work is a collaboration with B. Dumat and J.M. Mallet (ENS-PSL, Chemistry Dpt) and @florenceniedergang.bsky.social (Institut Cochin) 031
Jacques Fattaccioli @jfattaccioli.bsky.social · 20/11/2025Each particle carries pH-responsive BODIPY dyes on its surface and a stable reference probe in the core, enabling ratiometric readouts. By decorating the membrane with Fcγ-binding ligands, we drive controlled uptake and capture the earliest steps of phagosome formation. 120
Jacques Fattaccioli @jfattaccioli.bsky.social · 20/11/2025We introduce a modular biosensing strategy using targeted lipid microparticles to monitor phagosomal acidification in real time. These biomimetic particles are engineered to couple receptor-specific uptake with fluorescence-based pH reporting in macrophages. www.biorxiv.org/content/10.1... 131
Jacques Fattaccioli @jfattaccioli.bsky.social · 20/11/2025A collaboration between Alexandre Chargueraud, graduate student in our team (fattaccioli.github.io) and Lars Kool from the IPGG Microfabrication facility (www.plateformeipgg.fr). This work has been presented at the Micro and Nano Engineering (MNE) conference in 2024.fattaccioli.github.ioJacques Fattaccioli Microfluidics & Soft MatterOfficial website of Jacques Fattaccioli, Professor in Chemistry at Sorbonne Université. Research in microfluidics, soft matter, biophysics, and biotech innovation. 000
Jacques Fattaccioli @jfattaccioli.bsky.social · 20/11/2025We also built a Python/μManager interface that automates trapping, imaging, motion control, and bubble-free priming steps. The result is a robust, fully automated platform for high-throughput single-object studies, from screening assays to mechanobiology and dynamic imaging workflows. 100
Jacques Fattaccioli @jfattaccioli.bsky.social · 20/11/2025Confocal measurements reveal clear pressure-dependent deformation profiles, in excellent agreement with a thick-membrane model. Controlled fluidic and pneumatic actuation enables rapid, fully reversible trapping within seconds. 100
Jacques Fattaccioli @jfattaccioli.bsky.social · 20/11/2025We introduce a microfluidic device that can trap, analyze, and release individual microparticles on demand using membrane deformation driven by pneumatic pressure. The setup uses a deformable membrane suspended over an array of traps. www.sciencedirect.com/science/arti...sciencedirect.comFully integrated automatic microfluidic setup for immobilization, analysis and non-selective release of particlesWe present a microfluidic device that enables trapping, analysis and on-demand release of individual microparticles using membrane deformation induced… 161
Reposted by Jacques FattaccioliIsabelle Eisenmann @isabelleeisenmann.bsky.social · 11/11/2025Our work on hydrodynamic instabilities in active jets is on the cover of PRL this week! journals.aps.org/prl/abstract... A dialogue between experiment and theory, where we use light to control active suspensions and show how they can be destabilized by their self-generated flowsjournals.aps.orgPure Hydrodynamic Instabilities in Active Jets of Puller MicroalgaeUsing phototaxis to control cell orientation, various instabilities can be induced in jets of motile microalgae. 152
Jacques Fattaccioli @jfattaccioli.bsky.social · 02/11/2025Et le fait que globalement ça marche plus mal que les solution GAFAM. 100
Jacques Fattaccioli @jfattaccioli.bsky.social · 02/11/2025Et la plupart des solutions institutionnelles ne font clairement pas la comparaison, entre le fait que chacun fait des trucs dans son coin. Pour l'écriture partagée, il y sDrive, Resana etc etc. 100
Jacques Fattaccioli @jfattaccioli.bsky.social · 02/11/2025J'ai lu ton article dans le Monde. Je suis d'accord (comment ne pas l'être). Toutefois c'est très difficile sans supports techniques d'aller contre les GAFAM. Et des supports techniques il n'y en a point ou plus. 130
Reposted by Jacques FattaccioliInstitut Cochin @institutcochin.bsky.social · 10/10/2025#FDS2025 : @institutcochin.bsky.social a reçu dans ses laboratoires, 140 collégiens et lycéens. 11 équipes de recherche ou plateformes technologiques ont fait découvrir aux élèves la démarche scientifique et la recherche biomédicale. @cnrsbiologie.bsky.social @inserm.fr @upcite.bsky.social 053
Reposted by Jacques Fattaccioli@MEmilieTerret @memilieterret.bsky.social · 03/10/2025Thank you @cellmech2025.bsky.social for the invitation, great science, great people, great community! 2242
Jacques Fattaccioli @jfattaccioli.bsky.social · 09/08/2025A nice sky viewing night with family and kids, thanks to the Space Bus, in Corsica and under the full moon. Discovered these new (?) smart telescopes providing easy imaging of celestial bodies for a reasonable price 000
Reposted by Jacques FattaccioliPaolo Pierobon @paolopierobon.bsky.social · 08/08/2025First post in the Bsky-sphere! You’ll find info about my scientific activity, the DyCRIC team bit.ly/4lgSHk8, and @institutcochin.bsky.social ! 072
Jacques Fattaccioli @jfattaccioli.bsky.social · 09/08/2025The issue should still be there I guess :-) 010
Reposted by Jacques FattaccioliNature Chemical Biology @natchembio.nature.com · 21/05/2025A condensate-based approach reversibly sequesters lipid droplets (LDs) in cells, temporarily halting their functions and enabling detailed study of LD biology and the interactions of LDs with other cellular structures www.nature.com/articles/s41...nature.comControlling lipid droplet dynamics via tether condensates - Nature Chemical BiologyAmari et al. developed a condensate-based approach, named ControLD, for reversible trapping and release of lipid droplets inside living cells, temporarily halting their functions, enabling detailed st... 095
Reposted by Jacques FattaccioliZoher Gueroui 🦠🔬 @zgueroui.bsky.social · 21/05/2025What if we could trap Lipid Droplets and control their dynamics in cells? Our latest work does just that, using Engineered Condensates to manipulate LD behavior. Exciting results by Chems Amari and the team! Great collab with @abdourachidthiam.bsky.social #Organelles #Condensates rdcu.be/emYpU 2254
Jacques Fattaccioli @jfattaccioli.bsky.social · 28/04/2025J'ai deux tickets pour Shed Seven à la Maroquinerie le 2/5/2025. Pour les nostalgiques Britpop des 90's. Revente prix coûtant. 000
Reposted by Jacques FattaccioliESPCI Alumni @espcialumni.bsky.social · 18/04/2025Portrait d'Alexandre Chargueraud #ESPCIAlum Doctorant (encadré par @jfattaccioli.bsky.social) et lauréat du prix du public MT180 @sorbonne-universite.fr www.sorbonne-universite.fr/portraits/al...sorbonne-universite.frAlexandre Chargueraud 031
Reposted by Jacques FattaccioliESPCI Alumni @espcialumni.bsky.social · 13/03/2025Félicitations à Alexandre Chargueraud #ESPCIAlum, lauréat du Prix du Public de la finale de « Ma thèse en 180 secondes » @mt180fr.bsky.social de @sorbonne-universite.fr www.linkedin.com/posts/alexan... cc @espciparispsl.bsky.social @jfattaccioli.bsky.social 132
Reposted by Jacques FattaccioliSorbonne Université @sorbonne-universite.fr · 10/03/2025C'est parti pour la finale du concours "Ma thèse en 180 secondes" de Sorbonne Université ! 🙌 👉 RDV à partir de 18h en direct sur YouTube pour encourager nos doctorantes et doctorants : www.youtube.com/watch?v=Eqhi... #MT180 - @mt180fr.bsky.social 0113
Reposted by Jacques FattaccioliInstitut Cochin @institutcochin.bsky.social · 11/02/2025On Feb 11, we celebrate the International Day of Women and Girls in Science. @institutcochin.bsky.social exhibits gender equality among directions and team leaders and recruits young women with exceptional talent, among them in 2024 Clotilde Cadart: institutcochin.fr/en/news/inte... #WomenInScience 073
Reposted by Jacques FattaccioliESPCI Alumni @espcialumni.bsky.social · 17/11/2024Saviez-vous que de nombreuses plateformes de l'Université PSL sont ouvertes aux industriels ? 1re Journée de l’Innovation en Santé du Pôle PSL Innovation, sur le thème Biothérapies & Bioproduction 19 novembre 9h30-19h30 app.swapcard.com/event/journe... avec @jfattaccioli.bsky.social #ESPCIAlumapp.swapcard.com 011