Ever wondered how different regions of the gut are established? 🤔
Stem cells, right?
Turns out, not in the colon ❌.
The microbiome 🦠 — via region-specific metabolism — is an important regulator of colonocyte identity.
📄 New paper out in Cell
www.cell.com/cell/fulltex...
🧵 Thread below 👇
cell.com
Microbiome-produced nicotinic acid controls colon regional identity and injury susceptibility
The gut epithelium is regionally patterned to support digestive functions. In the
colon, this regionalization, which is extrinsically dictated by microbiome-derived
signals rather than through intrins...
