Reposted by Julia Dziabis
Super excited to share this new story led by @jedziabis.bsky.social where she defines a critical role for microglial innate immune signaling in PV cell and perineuronal net (PNN) development in hippocampus, and consequences for plasticity and behavior in adulthood www.biorxiv.org/content/10.6...
biorxiv.org
Microglial MyD88-dependent signaling influences extracellular matrix development and interneuron maturation in the hippocampus
Parvalbumin interneurons (PVIs) are disrupted across diverse neurodevelopmental disorders, highlighting their vulnerability to developmental perturbations. Inflammation can perturb PVI development and...