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Jay Hinton

@jayhinton.bsky.social
2.2K followers 1.3K following 1.3K posts

Salmonella admirer & Prof of Microbiology - Working on Salmonella bloodstream infections (iNTS) in sub- Saharan Africa context. Functional genomics. T1D.

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Jay Hinton @jayhinton.bsky.social · 01/12/2025
Congratulations to Dr Annis Newman ‼️ It was a pleasure to read Dr Newman’s PhD thesis - and then to spend this morning discussing the elegant science she did in @drprernavohra.bsky.social’s group at @edinburgh-uni.bsky.social
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Jay Hinton @jayhinton.bsky.social · 24/11/2025
I took this photo in Dec 2024 - it explains my belief that sunsets are incredible at this time of year… Another calm evening had turned West Kirby’s Marine Lake into a perfect mirror ‼️ 🌇💛 🌇💛 #Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
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Jay Hinton @jayhinton.bsky.social · 23/11/2025
The sunsets at this time of year are incredible. Last night’s was unforgettable — the calm evening turned West Kirby’s Marine Lake into a perfect mirror, reflecting the sky back at us. Truly life-affirming 🌇💛 🌇💛 #Sunset #BlueSky #Reflection #GoldenHour #WestKirby #Photography #PhotoOfTheDay
An incredible sunset reflected in a very still lake - a mirror lake
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Jay Hinton @jayhinton.bsky.social · 07/10/2025
📈 Reported cases of non-typhoidal Salmonella in England rose by 17% — from 8,872 in 2023 to 10,388 in 2024. Main culprits are S. Enteritidis (up 17%) and S. Typhimurium (up 15%), the most common reported serovars www.gov.uk/government/p...
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Jay Hinton @jayhinton.bsky.social · 23/01/2025
www.microbiologyresearch.org/content/jour...
The taxonomy & lifestyle of Salmonella Typhimurium
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Jay Hinton @jayhinton.bsky.social · 02/01/2025
#sunset from Thurstaton beach, with timbers from a shipwreck in the foreground… #wirral #merseyside #westkirby #sky #photography #clouds #photooftheday #beach #picoftheday #photo #skyphotography
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Jay Hinton @jayhinton.bsky.social · 01/01/2025
Happy 2025❗️ #sunset from West Kirby, this time with a navigation marker as contrast… #wirral #merseyside #westkirby #sky #photography #clouds #photooftheday #beach #picoftheday #photo #skyphotography
A sunset from West Kirby, with a navigational marker in the foreground, looking towards North Wales
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Jay Hinton @jayhinton.bsky.social · 31/12/2024
For New Year’s Eve, here’s last night’s #sunset from West Kirby. I’m looking forward to all the 🌅 of 2025… #wirral #merseyside #westkirby
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Jay Hinton @jayhinton.bsky.social · 31/12/2024
Here is Christmas Day’s #sunset reflected in the West Kirby Marine Lake - looking towards North Wales… #wirral #merseyside #westkirby #MirrorLake #NoFilters
sunset  from West Kirby, looking towards North Wales…
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Jay Hinton @jayhinton.bsky.social · 30/12/2024
For the holiday period, I’ll post some sunset photos I’ve taken in West Kirby on the Wirral peninsula in the UK. Here’s one from tonight ❗️ #wirral #merseyside #westkirby
Sunset looking towards North Wales, from West Kirby…
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Jay Hinton @jayhinton.bsky.social · 30/11/2024
Thanks for the belly laugh @tomgauld.bsky.social ‼️ @newscientist.bsky.social #sciart #microsky 🧪
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Jay Hinton @jayhinton.bsky.social · 13/11/2024
Incredible graphic - the myriad of ways that bacteria defend themselves against antibiotics. 14 resistance mechanisms, summarised by Idan Yelin & Roy Kishony in Cell www.sciencedirect.com/science/arti...
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Jay Hinton @jayhinton.bsky.social · 15/06/2024
12/ This couldn’t have been done without funding from @wellcometrust Thanks to @BrianKCoombes & @DrRobKingsley for their comments which improved the paper... & help from @MlwTrust @EarlhamInst @LivUni_IVES @LivUni @livuninews
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Jay Hinton @jayhinton.bsky.social · 15/06/2024
11/ This was an important collaboration between @MelitaGordon5, @nfeasey1, @RHeyderman @flashton2003 & scientists at @MlwTrust Invaluable contributions by @APredeus & @knalsal + members of HintonLab including @KroegerLab @zxj931_zhu @1caiseypulford @NWenner @yan_salsa @implosian
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Jay Hinton @jayhinton.bsky.social · 15/06/2024
8/ A series of pairwise fitness experiments by @zxj931_zhu showed the L2.2 strain to have a significant competitive advantage over L2.0 strain during mixed growth in minimal media Has the increased fitness of L2.2 contributed to the replacement of ST313 L2.0 in Malawi ❓
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Jay Hinton @jayhinton.bsky.social · 15/06/2024
7/ Transcripts can be viewed in genomic context & directly compared with Typhimurium strains D23580 & 4/74 here: ...
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Jay Hinton @jayhinton.bsky.social · 15/06/2024
6/ RNA-seq revealed transcriptional profile of L2.2 in multiple in vitro growth conditions & within murine macrophages We announce SalComD37712, where all gene expression data can be interrogated: 👇...
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Jay Hinton @jayhinton.bsky.social · 15/06/2024
5/ In terms of accessory genome, L2.2 and L2.0 share the same prophages, including BTP1 & BTP5 L2.2 lacks the pBT1 & pBT2 plasmids
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Jay Hinton @jayhinton.bsky.social · 15/06/2024
4/ Genomic comparison of L2.2 strain D37712 with L2.0 strain D23580 identified 26 chromosomal SNP differences The sseI gene is absent: L2.2 does not encode the SPI2-translocated SseI effector protein Important pseudogenes include spvD, ratB, bcsG & lpxO. macB gene is functional
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Jay Hinton @jayhinton.bsky.social · 15/06/2024
3/ Building on seminal papers from @DrRobKingsley @sandravanpuy and @1caiseypulford Our study shows that ST313 lineage 2 has continued to evolve since 2008 New analysis of data from 10,000 Salmonella Genomes project #10KGSP, which was led by @BlancaPerSep & @neilhall_uk
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Jay Hinton @jayhinton.bsky.social · 15/06/2024
2/ Salmonella Typhimurium ST313 lineage L2.2 first emerged in 2006, followed by L2.3 in 2008. By 2018, L2.2 & L2.3 lineages were more frequently observed than L2.0 in Blantyre @microLifeJrnl @MelitaGordon5...
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Jay Hinton @jayhinton.bsky.social · 15/06/2024
1/ Excited to announce our latest contribution to understanding genomic epidemiology of Salmonella Typhimurium ST313 #iNTS Analysis of genomes of Salmonella bloodstream isolates from Blantyre, Malawi 1996-2018 identified two new ST313 sub-lineages: L2.2 & L2.3 @microLifeJrnl
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Jay Hinton @jayhinton.bsky.social · 24/02/2024
The HintonLab SalCom transcriptomic databases are back on online TODAY❗️#Salmonella SalComMac: bioinf.gen.tcd.ie/cgi-bin/jay/... SalComRegulon: bioinf.gen.tcd.ie/cgi-bin/jay/... SalComD23580: bioinf.gen.tcd.ie/cgi-bin/jay/... SalComs offline in Feb 2024, they had to be rebuilt after a cyberattack
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Jay Hinton @jayhinton.bsky.social · 06/02/2024
I’m liking this shiny app that gives you a word cloud based on your Google Scholar profile: shiny.rcg.sfu.ca/u/rdmorin/sc... #rstats #genomics #bioinformatics #Salmonella
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Jay Hinton @jayhinton.bsky.social · 06/02/2024
This shiny app that gives you a word cloud based on your Google Scholar profile is pretty slick... shiny.rcg.sfu.ca/u/rdmorin/scholar_… #rstats #genomics #bioinformatics #Salmonella
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Jay Hinton @jayhinton.bsky.social · 02/02/2024
Benchmarking of computational predictions of antimicrobial resistance phenotypes - from genomes of a variety of bacterial species www.biorxiv.org/content/10.1101/202…
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Jay Hinton @jayhinton.bsky.social · 31/01/2024
Prof Dave Hodgson from Warwick University Biological Sciences dept will be sorely missed… His funeral will be held in Coventry on Fri 2nd Feb - DM me if you’d like details… This tribute is now on the @MicrobioSoc website: microbiologysociety.org/news/society...
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Jay Hinton @jayhinton.bsky.social · 13/01/2024
The housing crisis is still being underplayed Young adults are being robbed of the milestones that marked the lives of previous generations… www.ft.com/content/f216...
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Jay Hinton @jayhinton.bsky.social · 25/12/2023
Five cheeses recalled in UK over Christmas E. coli fears www.bbc.co.uk/news/uk-6781...
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Jay Hinton @jayhinton.bsky.social · 13/12/2023
I’m looking forward to speaking at Southampton Uni today at 14.00 [in Life Sciences room B2/5053] - my first visit since 2021 The train is providing a nice place to prepare… Just need to finalise my talk now❗️ Thanks to Franklin Nobrega for the invite…
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Jay Hinton @jayhinton.bsky.social · 13/12/2023
I’m looking forward to speaking at @sotonbiosci today at 14.00 [in room B2/5053] - my first visit to Southampton Uni for 20 years The train is providing a nice place to prepare… Just need to finalise my talk now❗️ Thanks to @NobregaFL for the invite…
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Jay Hinton @jayhinton.bsky.social · 29/11/2023
Excellent visit to my alma mater - I started my PhD at EdinburghUni 41 years ago❗️ I particularly enjoyed meeting the next generation of bacteriologists/infection biologists working at Edinburgh University & Roslin Institute‼️ Thanks to Prerna Vohra for hosting my visit…
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Jay Hinton @jayhinton.bsky.social · 28/11/2023
Excited to be visiting my alma mater - I started my PhD in this building at @EdinburghUni 40 years ago❗️ Looking forward to meeting @DrPrernaVohra @JasonPMooney @strain9000 & others… My talk about #Salmonella in the African setting will be at @roslininstitute at 15.00 today
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Jay Hinton @jayhinton.bsky.social · 01/10/2023
www.theguardian.com/global-developm…
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Jay Hinton @jayhinton.bsky.social · 18/08/2023
SieA protein of Salmonella phage P22 responsible for superinfection - The SieA inner membrane protein blocks DNA injection by P22 & related phages (but not by other tailed phages). SieA disrupts the DNA delivery mechanism in #Salmonella...
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Jay Hinton @jayhinton.bsky.social · 15/08/2023
Exciting to be visiting @ThurstonLab & colleagues at @ImperialInfect @CBRB_Imperial @imperialcollege to discuss our shared fascination about #Salmonella effector proteins… With @yan_salsa & @LijuanAda from @LivUni
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Jay Hinton @jayhinton.bsky.social · 28/07/2023
2/2 Now encouraging the #Salmonella research community to join our quest to understand iNTS pathogenesis Email me if you would like to start experiments with several isolates that represent the clades of S. Typhimurium & S. Enteritidis that have evolved in Africa #SalmonellaGRC
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Jay Hinton @jayhinton.bsky.social · 28/07/2023
1/2 The #SalmonellaGRC 2023 is over... I’m already looking forward to the next one in 2025‼️ #HintonLabOnTour again… Our group is linking #iNTS gene function to #Salmonella virulence - with a backdrop of the Tuscan hills…
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Jay Hinton @jayhinton.bsky.social · 25/07/2023
At the #GRCSalmonella conference in Italy, we’re keeping focused on the problem of bloodstream #iNTS infections in Africa - despite the⛈️ Here with @SamKariuki2, @MelitaGordon5 & @AislingBrady95 #Salmonella
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Jay Hinton @jayhinton.bsky.social · 24/07/2023
Remarkable science at the first day of the #GRCSalmonella with @TsolisRenee, @KnodlerLeigh @afc_immuno Stephen McSorley & @HendersonLab
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Jay Hinton @jayhinton.bsky.social · 12/07/2023
At #FEMS2023, today is the day to see Dr Mengru Yang’s @Mengru_9 Poster (16.30 -18.00) - focused on assembly of the fascinating intracellular propanediol microcompartment of #Salmonella From @luningliu lab. See for more details👇 doi.org/10.1038/s41467-022-30608-w
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Jay Hinton @jayhinton.bsky.social · 18/06/2023
Proud day❗️Dr Yan Li’s @yan_salsa successful thesis defence… Followed by a classic LabH Viva Party ‼️ CONGRATULATIONS Yan & thanks to external examiner @DrRobKingsley @LivUni_IVES @LivUni
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Jay Hinton @jayhinton.bsky.social · 16/06/2023
3/4 Of 3956 S. Typhimurium RNA transcripts, most half-lives are < 1 min. ~500 transcripts have half-life >2.5 mins, & are preferentially bound by RBPs
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Jay Hinton @jayhinton.bsky.social · 16/06/2023
2/4 This new paper from @LBarquist @JoergLab Alex Westermann & their teams reveal new accurate decay rate estimates: Bacterial transcripts have half-lives @ 3-times shorter than previously thought‼️ Median RNA half-life in Salmonella in early stationary phase is 1 minute.
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Jay Hinton @jayhinton.bsky.social · 24/05/2023
We had an interesting stand-off beside the River Conwy in North Wales this afternoon. He decided we weren’t worth chasing after all… #countrylife #farmlife #britishcountryside #Conwy
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Jay Hinton @jayhinton.bsky.social · 20/05/2023
Irises at Bodnant Garden, near Conwy Wales ⁦@BodnantGardenNT⁩
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Jay Hinton @jayhinton.bsky.social · 15/04/2023
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Jay Hinton @jayhinton.bsky.social · 15/04/2023
@astacus I’m guessing you will know who this beauty is?
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Jay Hinton @jayhinton.bsky.social · 30/11/2022
A pleasure to attend the executive board of the European Academy of Microbiology in Brussels - our first post-pandemic in-person meeting❗️ Good to hear that the Academy’s @microLifeJrnl is making great progress… #EAMicro @FEMSmicro @JoergLab
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Jay Hinton @jayhinton.bsky.social · 24/11/2022
4/4 And finally: the all-important group picture, with our valued collaborators from @UKHSA… In front of the iconic photo of Betty Hobbs.
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