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Sophie Janssens Lab

@janssenslab.bsky.social

dendritic cell biology lab, interested in how dendritic cells maintain the balance between tolerance and immunity, and in the role of the UPR in immune cell functioning

Posts Replies Media

Sophie Janssens Lab @janssenslab.bsky.social · 28/07/2026

Looking forward to joining the dendritic cell meeting in San Diego and meeting colleagues and friends. Will you join? Check out www.dc2026sandiego.com

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Sophie Janssens Lab @janssenslab.bsky.social · 19/07/2026

This process is specific to cDC1s and is only required during homeostatic not immunogenic maturation. Thanks to @erc.europe.eu for financially supporting this ERC_CoG DCRIDDLE. Thanks to @viblifesciences.bsky.social and @ugent-fge.bsky.social for their continued support of our team.

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Sophie Janssens Lab @janssenslab.bsky.social · 19/07/2026

A sneak preview: In contrast to most secretory cell types where IRE1 gets activated by accumulation of unfolded proteins in the ER, IRE1 gets activated by cholesterol influx during apoptotic cell engulfment in cDC1s. IRE1-dependent RIDD enables cholesterol efflux during homeostatic DC maturation.

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Sophie Janssens Lab @janssenslab.bsky.social · 19/07/2026

Almost 15 years after our initial observation that IRE1 is specifically active in cDC1s, we finally start understanding why… Check out the new study from @victor-bosteels.bsky.social, published in @natcomms.nature.com in press @https://rdcu.be/fur4Q

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Sophie Janssens Lab @janssenslab.bsky.social · 10/12/2025

Great news, Jan! Well deserved!

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Sophie Janssens Lab @janssenslab.bsky.social · 10/09/2025

😂 there have to be rules for everything😉. Thanks, Caetano, it was an honour (and pleasure) to be evaluated by you and a great panel of top scientists!

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Sophie Janssens Lab @janssenslab.bsky.social · 21/08/2025

Thanks to @viblifesciences.bsky.social and @ugent-fge.bsky.social for their support and all VIB Cores, especially @singlecellcore.bsky.social for their tremendous help. Enjoy the reading!

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Sophie Janssens Lab @janssenslab.bsky.social · 21/08/2025

A publicly available web-interface can be used to calculate the maturation score of your mature DCs of interest. www.single-cell.be/Spleen_cDC1_...

single-cell.be

Spleen cDC1 LNP maturation

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Sophie Janssens Lab @janssenslab.bsky.social · 21/08/2025

A meta-analysis confirms that homeostatic and immunogenic mature signatures are conserved across tissues and DC subsets, supporting a unified nomenclature for mature DCs.

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Sophie Janssens Lab @janssenslab.bsky.social · 21/08/2025

Our study revealed that empty LNPs do not induce immunogenic maturation of DCs, while mRNA-containing lipids do, showing that the cargo, not the lipids, determine adjuvanticity.

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Sophie Janssens Lab @janssenslab.bsky.social · 21/08/2025

By using an approach relying on the induction of homeostatic DC maturation by uptake of empty LNPs and immunogenic DC maturation by TLR ligand-adjuvanted LNPs, and performing CITE-SEQ, a flow cytometry panel was designed to assign mature DCs as immunogenic or homeostatic.

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Sophie Janssens Lab @janssenslab.bsky.social · 21/08/2025

In the new Resource paper from Sofie Rennen and @victor-bosteels.bsky.social, published in @cp-cellreports.bsky.social, they present a method to reliably annotate them. www.cell.com/cell-reports...

cell.com

Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways

Rennen et al. provide methods to distinguish homeostatic from immunogenic mature cDC1s, based on lipid nanoparticle (LNP)-induced maturation. Only the uptake of TLR ligand- or mRNA-encapsulated LNPs i...

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Sophie Janssens Lab @janssenslab.bsky.social · 21/08/2025

Ever wondered how to deconvolute homeostatic from immunogenic mature dendritic cells by flow cytometry or by using transcriptional profiling?

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