This cross-sectional study analyzes associations of ABO nonidentical transfusions with mortality among patients undergoing massive transfusion protocol.

This cohort study evaluates trends, between-hospital variation, and patient and institutional factors associated with balanced component and whole-blood transfusion in US trauma centers.

Kunihiro Hattori, Tomoyuki Igawa, and Takehisa Kitazawa, who developed a prophylactic therapy for hemophilia A, have received the 2026 Lasker–DeBakey Clinical Medical Research Award.

Blood transfusion before arrival at a hospital reduces mortality from traumatic hemorrhage and shock. Whether transfusion with whole blood is more beneficial than transfusion with blood components ...

This cohort study determines whether an operator-level association of volume and outcomes exists for transcatheter aortic valve replacement (TAVR) and mitral transcatheter edge-to-edge repair (MTEER) ...

This prospective management outcome study conducted at multiple centers in Belgium, Canada, France, and Switzerland assesses whether using an age-adjusted D-dimer cutoff allows clinicians to safely ru...

A heparinase-containing cartridge for the TEG® 6s system to neutralize this effect was recently cleared by the U.S. Food and Drug Administration, but validation in clinical settings had been limited. ...

A multicenter study highlighted in Anesthesiology Journals clinically validated our TEG® 6s Global Hemostasis – HN cartridge by demonstrating high correlation with established assays in heparinized pa...

This randomized clinical trial tests whether a liberal compared with a restrictive transfusion strategy lowers the risk of a cardiac event 90 days after major vascular or general surgery among patient...

This Viewpoint discusses the need for the US health care system to prepare for war casualties through military and civilian health care collaboration.

Michael Welsh, Jesús González, and Paul Negulescu have won the 2025 Lasker–DeBakey Clinical Medical Research Award for their roles in developing treatments for cystic fibrosis.

Drs. Görlich and McKnight have won the 2025 Albert Lasker Award for Basic Medical Research for showing that low-complexity domains of proteins lack structure on their own and yet can form assembled .....

Cell Research - Soluble tissue factor generated by necroptosis-triggered shedding is responsible for thrombosis

Black individuals undergoing percutaneous coronary intervention (PCI) experience higher rates of major adverse cardiovascular events (MACE) than non-Black individuals. This study assessed the racial ...

In patients with STEMI with cardiogenic shock, early mechanical support with a microaxial pump reduced the risk of death at 180 days, with the survival benefit persisting up to 10 years despite dev...

This randomized clinical trial compares discontinuing vs continuing oral anticoagulant therapy in patients without documented atrial arrhythmia recurrence after catheter ablation for atrial fibrillati...

These findings add to the evidence that clopidogrel monotherapy is superior to aspirin monotherapy for MACCE prevention with no increase in the risk of bleeding, and support the preferential use of cl...

Study Reveals Caffeine May Undermine Blood Transfusion Effectiveness

AbstractBackground and Aims. Dual antiplatelet therapy (DAPT) de-escalation strategies improve outcomes after percutaneous coronary intervention (PCI) comp

Patients undergoing cardiac surgery often receive red-cell transfusions, along with the associated risks and costs. Early intraoperative normovolemic hemodilution (i.e., acute normovolemic hemodilu...

Transcatheter aortic-valve implantation (TAVI) is associated with procedure-related stroke. Cerebral embolic protection (CEP) devices may reduce embolization to the cerebral circulation and hence t...

Later last night at #ISTH2025, we had the privilege of honoring a gentle giant of the field—Dr. Hau Kwaan, MD, PhD, FRCP, FACP, Professor Emeritus at Northwestern University - The Feinberg School of M...

How to make sense of all the vaccine policy changes.

The health service issued an "amber alert" last year and stocks remain low ever since.

The Boston Bruins hired Marco Sturm as coach on Thursday to help the Original Six franchise get back to the playoffs after missing them for the first time since 2016.

This Special Communication discusses the updated Association for the Advancement of Blood and Biotherapies and the International Collaboration for Transfusion Medicine Guidelines international clinica...

On the 80th anniversary of the end of the Second World War, Federal President Steinmeier has called for remembrance not to become routine. “Our history is a precious treasure trove of experience. Let us trust in our experience,” he said at a commemoration ceremony in the Bundestag.

This feature about a woman with device-detected atrial fibrillation offers a case vignette accompanied by two essays, one supporting the initiation of anticoagulant therapy and the other ...

Our exploratory machine learning–based analysis of data from the CRASH-2 and CRASH-3 trials suggests that tranexamic acid should be administered as soon as

Podcast Episode · Boston Children's Answers Parentcast · 04/29/2025 · 22m

Study on the prognostic value of invasive and echocardiography-derived gradients after TAVI with balloon-expandable and self-expanding valves.

o 8 U of red blood cells (RBCs). We describe transfusion ratios when cryoprecipitate was indicated by viscoelastic testing (VET) and evaluated whole blood (WB)'s impact on this ratio. METHODS Adult...

Obstetric hemorrhage remains the leading cause of maternal mortality, accounting for about 27% of deaths during pregnancy and the following 6 weeks, a new study has found.

Inhibition of factor XI has emerged as a promising strategy to mitigate bleeding while potentially preserving antithrombotic efficacy. In this Review, the authors comprehensively discuss the rationale...