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Structure-performance relationships for catalysis-driven molecular machinery
Molecular machine properties such as speed, efficiency, power, and torque depend upon particular features of structure, mechanism, and chemistry. The graphical abstract shows a Top Trumps-style representation of key performance indicators, illustrating how the first generation of synthetic catalysis-driven small-molecule machines compare with their biomolecular analogs. The understanding of how molecular machine design affects properties should aid technological advancements and a deeper understanding of the fundamental principles that link physics, chemistry, and biology.