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James Gallagher

@jamesgallagher.bsky.social
130 followers 177 following 13 posts

MSCA Postdoc in the Toste group at Berkeley. PhD Leigh group at Manchester. Dynamic catalysis and nonequilibrium chemistry.

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Reposted by James Gallagher
Stefan Borsley @stefanborsley.bsky.social · 03/08/2026
First paper featuring one of my students out now in @jacs.acspublications.org! The brilliant Willow Baxter teamed up with the group of @giuliosflask.bsky.social to show how we can pump gradients across lipid bilayer membranes, and harness them to drive other processes. pubs.acs.org/jacsat/artic...
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Reposted by James Gallagher
Chem by Cell Press @cp-chem.bsky.social · 03/10/2025
Online now: Structure-performance relationships for catalysis-driven molecular machinery
dlvr.it
Structure-performance relationships for catalysis-driven molecular machinery
Molecular machine properties such as speed, efficiency, power, and torque depend upon particular features of structure, mechanism, and chemistry. The graphical abstract shows a Top Trumps-style representation of key performance indicators, illustrating how the first generation of synthetic catalysis-driven small-molecule machines compare with their biomolecular analogs. The understanding of how molecular machine design affects properties should aid technological advancements and a deeper understanding of the fundamental principles that link physics, chemistry, and biology.
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James Gallagher @jamesgallagher.bsky.social · 03/10/2025
The physics of molecular machinery can be confusing. We developed a plug-and-play interactive tool based on trajectory thermodynamics. The user can now visualise how/why motors move directionally or respond to a force (see video), without knowledge of the physics or maths. github.com/JoaquinBaixe...
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James Gallagher @jamesgallagher.bsky.social · 03/10/2025
In biology, molecular machines exist to perform useful functions. Artificial molecular machines now move in the same way as those in biology, but they do not yet perform tasks. Out now in Chem, a guide to task performance in molecular machinery. www.cell.com/chem/fulltex... @cp-chem.bsky.social
cell.com
Structure-performance relationships for catalysis-driven molecular machinery
Molecular machine properties such as speed, efficiency, power, and torque depend upon particular features of structure, mechanism, and chemistry. The graphical abstract shows a Top Trumps-style repres...
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Reposted by James Gallagher
Ben Roberts @benjaminoacid.bsky.social · 01/08/2025
Information ratchets drive many molecular motors, but we can also use them for other nonequilibrium processes like performing error correction in a molecular recognition process to increase selectivity. Published today in @natnano.nature.com www.nature.com/articles/s41...
nature.com
An information ratchet improves selectivity in molecular recognition under non-equilibrium conditions - Nature Nanotechnology
An abiotic information ratchet mechanism increases selectivity for the correct DNA duplex from 2:1 at equilibrium to 6:1 under energy-dissipating conditions.
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Reposted by James Gallagher
Ben Roberts @benjaminoacid.bsky.social · 24/02/2025
I’m excited to share that I will be moving to the University of Ulm as a junior group leader and I have a fully-funded open PhD position co-supervised by me and Max von Delius @mvdelius.bsky.social . Apply at benjamin.roberts@unipd.it, any shares would be appreciated! www.bmwrlab.com/work-with-us
bmwrlab.com
Work with us | The Roberts Lab
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Reposted by James Gallagher
Dave Leigh @profdaveleigh.bsky.social · 15/01/2025
Peng-Lai, @stefanborsley.bsky.social, Martin & our collaborators Alessandro and @giusepponelab.bsky.social demonstrate how a catalyst transduces chemical energy to perform mechanical work in www.nature.com/articles/s41... in @nature.com. tinyurl.com/jny7nen5. Animation @scicommstudios.bsky.social😀
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