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JAMA Otolaryngology @jamaotolaryngology.com · 13/10/2026

In #SensorineuralHearingLoss, pure-tone average phenotyping identified more genome-wide significant loci and higher heritability than diagnostic code–based phenotyping. ja.ma/4ydZ7Hn

Two Manhattan plots. Top: ICD-based GWAS (n=61468) shows no peaks above the P=5x10^-8 significance line. Bottom: PTA-based GWAS (n=16057) shows significant peaks (rs10176445, rs4413512, rs199904900). X-axis: Chromosome 1-23, Y-axis: -log10(P value).

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JAMA Otolaryngology @jamaotolaryngology.com · 13/10/2026

Among patients receiving radiotherapy for #HeadAndNeckCancer, higher skeletal muscle and lower intermuscular adiposity on pretreatment #ComputedTomography were associated with improved overall survival. ja.ma/4zsBVWC

Kaplan-Meier survival curve shows overall survival (%) over 6 years for Obesity (dark gray), Overweight (orange), Healthy (blue), and Underweight (light green) groups. The Underweight group has significantly lower survival rates. Obesity, Overweight, and Healthy groups show higher, similar survival.

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JAMA Otolaryngology @jamaotolaryngology.com · 10/10/2026

In #SensorineuralHearingLoss, pure-tone average phenotyping identified more genome-wide significant loci and higher heritability than diagnostic code–based phenotyping. ja.ma/3TzNFHQ

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JAMA Otolaryngology @jamaotolaryngology.com · 10/10/2026

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JAMA Otolaryngology @jamaotolaryngology.com · 08/10/2026

In #SensorineuralHearingLoss, pure-tone average phenotyping identified more genome-wide significant loci and higher heritability than diagnostic code–based phenotyping. ja.ma/4yMY0zl

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JAMA Otolaryngology @jamaotolaryngology.com · 08/10/2026

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JAMA Otolaryngology @jamaotolaryngology.com · 25/09/2026

A tracheostomy-specific #Tracheostomy risk-tier system for children separated prolonged hospitalization and in-hospital mortality better than All Patient Refined Diagnosis Related Group severity classification. ja.ma/4rpdJle

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JAMA Otolaryngology @jamaotolaryngology.com · 25/09/2026

For patients with #ObstructiveSleepApnea treated with hypoglossal nerve stimulation, low arousal threshold was associated with a shift from 3-month adherence to 6-month nonadherence. ja.ma/4roCjTf

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JAMA Otolaryngology @jamaotolaryngology.com · 25/09/2026

A 34-year-old man with no significant medical history presented with progressive dysphonia, dysphagia, and an infiltrative laryngeal mass that remained nondiagnostic on multiple biopsies. What was the diagnosis? ja.ma/4dNuEbt

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JAMA Otolaryngology @jamaotolaryngology.com · 17/09/2026

Among patients undergoing head and neck #FreeFlap reconstruction or #TransoralRoboticSurgery, adjunctive #Suzetrigine was associated with lower inpatient opioid use and similar postoperative pain scores. ja.ma/4Akh0Gs

Four plots show mean MME & MME/day for Suzetrigine (n=11/30) vs. Control (n=21/80) groups in TORS (plots A, B) & free flap (plots C, D) procedures. Suzetrigine consistently has lower mean MME & MME/day across all comparisons.

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JAMA Otolaryngology @jamaotolaryngology.com · 17/09/2026

💬 Editorial: A single narrative arc and the And–But–Therefore framework can help scientific findings clearly communicate the problem, the evidence gap, and the reason the audience should care. ja.ma/472YwwR

Editorial from JAMA Otolaryngology–Head & Neck Surgery: "Three Pillars of Effective Scientific Communication: Telling the Story" by Jay F. Piccirillo, MD, and Randy Olson, PhD. Published online September 17, 2026. DOI: 10.1001/jamaoto.2026.2891.

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JAMA Otolaryngology @jamaotolaryngology.com · 07/09/2026

For #HeadAndNeckSquamousCellCarcinoma surveillance, tissue-informed #ctDNA positivity was sometimes the first sign of recurrence and showed high positive and negative predictive value. ja.ma/4igsx38

A three-part graph. A) Swimmer plot of patient surveillance shows ctDNA test results (negative: blue squares; positive: red circles) & recurrence (red X) over time. B) Patient 1's ctDNA rises from negative to >2 MTM/mL over 16 months, with PET/CT/Biopsy. C) Patient 2's ctDNA fluctuates around 1.5 MTM/mL over 13 months, with PET/CT.

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JAMA Otolaryngology @jamaotolaryngology.com · 06/09/2026

📣 Special Communication: In #PrimaryHyperparathyroidism, imaging should be reserved for after biochemical diagnosis, and #Ultrasonography is the preferred first study because it involves no ionizing radiation. ja.ma/4yt6ACZ

Table comparing patient-based examination sensitivity (%) and total effective dose equivalent (TEDE, mSv) across imaging modalities. Ultrasonography, MRI, and 4DMRI show 0 mSv. 8F-fluorocholine PET/CT has highest sensitivity (92-99%). 4DCT has highest dose (9.3-20.2 mSv).

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JAMA Otolaryngology @jamaotolaryngology.com · 06/09/2026

In #PapillaryThyroidCarcinoma, #TERT promoter variants increased with age across 3 cohorts, indicating that molecular status may explain much of the worse prognosis associated with older age. ja.ma/4x7bunN

Three bar charts display TERT variations (%) by age group across MDACC/VUMC/UW, TCGA, and GENIE studies. All charts show an increasing trend of TERT variations with age, particularly from 45-55 years onward, peaking in the ≥65 age group. Associated data tables provide TERT status counts.

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JAMA Otolaryngology @jamaotolaryngology.com · 10/08/2026

📝 JAMA Otolaryngology #Review: For human papillomavirus–independent #HeadAndNeckCancer, circulating tumor DNA positivity was associated with worse survival outcomes. ja.ma/4bCkcmk

Article from JAMA Otolaryngology-Head & Neck Surgery: 'Circulating Tumor DNA in Head & Neck Cancer.' Two forest plots show pooled Hazard Ratios (HR) for ctDNA-positive vs. negative status for A) Progression-free survival and B) Recurrence-free survival. Most HRs indicate better survival for ctDNA-negative patients.

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JAMA Otolaryngology @jamaotolaryngology.com · 09/08/2026

In locally advanced #HeadAndNeckCancer, perioperative #Pembrolizumab was cost-effective only for patients with programmed cell death 1 ligand 1 combined positive score >10, supporting biomarker-stratified immunotherapy use. ja.ma/3TO1amQ

Figure 3. Cost-Effectiveness Acceptability Curves. Two plots show probability of cost-effectiveness vs. WTP/QALY. A (CPS 1-10) shows Control more effective than Pembrolizumab. B (CPS ≥10) shows Pembrolizumab becomes more effective than Control around $150K WTP/QALY.

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JAMA Otolaryngology @jamaotolaryngology.com · 09/08/2026

In #AirwayEndoscopy, a structured #HumanFactors program was associated with fewer door openings and phone interruptions during critical phases, while short-term clinical outcomes were unchanged. ja.ma/4zb8CJ8

Bar graph titled 'Comparison of Pretesting and Posttesting Intraoperative Adverse Events'. Adverse events (%) by type: Atropine injection, Ext cardiac massage, Sr ENT surgeon takeover, SpO2 below 80%. Pretesting shows higher events (e.g., SpO2 below 80% at 31%), posttesting shows reduction, with several events at 0%.

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JAMA Otolaryngology @jamaotolaryngology.com · 08/08/2026

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JAMA Otolaryngology @jamaotolaryngology.com · 08/08/2026

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JAMA Otolaryngology @jamaotolaryngology.com · 08/08/2026

In a multicenter cohort of patients with type 2 #Diabetes, use of glucagon-like peptide-1 receptor agonists (#GLP-1 RAs) was associated with increased risk of smell and taste disturbances compared with other #antidiabetic medications. ja.ma/4wORmrt

JAMA Otolaryngology–Head & Neck Surgery: Original Investigation, "Smell and Taste Disturbances Among Glucagon-Like Peptide-1 Receptor Agonist Users" by Jonathan & Nir Zontag. Published June 25, 2026. doi: 10.1001/jamaoto.2026.1498

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JAMA Otolaryngology @jamaotolaryngology.com · 12/07/2026

#HypoglossalNerveStimulation is an implanted device for #ObstructiveSleepApnea that stimulates the tongue nerve during sleep to help keep the airway open—an option for patients who cannot use CPAP. ja.ma/4vXiJPo

A swarm plot displays Log10 viral load for two PCR primers. The Y-axis is Log10 viral load from 0-6. The X-axis has UL83 IU/µg gDNA and IE1 IU/µg gDNA. UL83 data is mostly between 1.5-2.5, with outliers up to 5.5. IE1 data is generally higher, clustered between 3-4, with outliers up to 5.2.

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JAMA Otolaryngology @jamaotolaryngology.com · 12/07/2026

Among adults with type 2 #Diabetes, GLP-1 receptor agonist use was associated with greater risk of smell and taste disturbances compared with other antidiabetic medications. ja.ma/4aJSgwn

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JAMA Otolaryngology @jamaotolaryngology.com · 11/07/2026

Dried blood spot (#DBS) PCR showed 86% sensitivity and 99.5% specificity for cCMV detection in #newborns identified by expanded targeted #testing, especially those with moderate to severe #disease. ja.ma/4aILabA

Figure 2. Forest Plot of the Primary Meta-Analysis on Subjective Olfactory Impairment (SOI) and Depression. The plot shows 7 studies with participant numbers and OR (95% CI) values. Individual study effects are squares with lines; total effect (1.56 [1.19-2.05] for 165,340 participants) is a diamond, mostly right of OR=1, indicating association.

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JAMA Otolaryngology @jamaotolaryngology.com · 11/07/2026

Among patients undergoing head and neck #Reconstruction, quality-of-life did not stabilize at 1 year, with complications at 12 months being the most prominent modifiable risk factor for deterioration. ja.ma/4vZ0vNK

Graph: QOL physical domain score (left axis) and Patients, % (right axis) over Postoperative time, y (0-3). Mean QOL declines from 80 to ~68, then stabilizes. Deteriorated patients decrease from ~50% at year 1 to ~30% by year 2; Improved patients increase from ~12% to ~30% by year 2.

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JAMA Otolaryngology @jamaotolaryngology.com · 25/06/2026

Line and bar chart showing QOL physical domain score & patient percentages over postoperative time (0-3 years). Mean QOL declines initially then stabilizes near 70. At 1 year, ~50% deteriorated, ~10% improved. By 3 years, ~35% deteriorated, ~20% improved.

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JAMA Otolaryngology @jamaotolaryngology.com · 25/06/2026

📝 Scoping review: Validated #SDoH tools for #HeadAndNeckCancer mostly assess economic stability, with limited measurement of social context, health care access, or environment. ja.ma/43Q6IPB

JAMA Otolaryngology-Head & Neck Surgery article titled 'Tools for Identifying Social Determinants of Health in Head and Neck Cancer A Scoping Review' by Zasloff, Hunter, Khanna, et al. Published online April 30, 2026. DOI: 10.1001/jamaoto.2026.0681.

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JAMA Otolaryngology @jamaotolaryngology.com · 23/06/2026

Routine postdissection V2 stimulation during #thyroidectomy improved detection of nerve injury risk and may prevent bilateral vocal cord palsy compared to selective or R2-only monitoring. ja.ma/3QZziem

Table 2: Indications for Surgery for Group 1 (n=784) & Group 2 (n=240) patients. Top indications for surgery are Suspicious FNA (fine needle aspiration), Cancer diagnosis on FNA, Graves disease or hyperthyroidism, and Compressive symptoms.

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JAMA Otolaryngology @jamaotolaryngology.com · 22/06/2026

Otolaryngology surgeons showed high intraoperative ergonomic risk and acute pain, with increased risk linked to procedure difficulty, glove size, and age ≥40 years. ja.ma/4uJmvKP

Graph: Predicted RULA scores (%) versus No. of procedures, separated by age group. For those <40 y (dark teal points), scores remain stable around 4.5-4.6. For those ≥40 y (orange points), scores increase from approximately 4.0 to over 5.5 as procedures rise.

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JAMA Otolaryngology @jamaotolaryngology.com · 21/06/2026

In patients with #HPV-associated #OropharyngealCancer, definitive treatment with deintensified 60‑Gy #Radiotherapy, with or without chemotherapy, was associated with low long-term locoregional recurrence and favorable survival outcomes. ja.ma/4vokCoj

Line graph shows cumulative incidence of events (%) over 5 years. 'Distant' events (dark) increase steadily to ~10% by year 5. 'Locoregional' (orange) increases to ~5%. 'Competing death' (light blue) remains below 5%. No. at risk decreases from 240 to 168.

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JAMA Otolaryngology @jamaotolaryngology.com · 20/06/2026

In adults with recurrent acute #Rhinosinusitis, endoscopic sinus surgery was more effective than medical treatment alone for achieving clinically meaningful improvement in symptoms. ja.ma/44qs8CV

RCT on Endoscopic Sinus Surgery (ESS) for rhinosinusitis. 59 patients (7M, 52F, avg age 40) in Finland. ESS+medical treatment vs. medical treatment alone. Findings show ESS+med treatment led to 77.8% SNOT-22 improvement vs. 33.3% for medical treatment only.

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JAMA Otolaryngology @jamaotolaryngology.com · 20/06/2026

Among survivors of #Oropharyngeal #Cancer, higher MD Anderson Symptom Inventory–Head and Neck symptom scores were associated with later risk of #HypoglossalNeuropathy, supporting early patient-reported symptom surveillance. ja.ma/4elOxqX

Kaplan-Meier plots of hypoglossal nerve neuropathy-free survival. Three graphs show LCNP-free probability (Y-axis) over 60 months (X-axis). Groups with 'High' scores (MDASI-HN-NERVE or Voice/speech) consistently have lower LCNP-free probability than 'Low' score groups.

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JAMA Otolaryngology @jamaotolaryngology.com · 19/06/2026

Pembrolizumab combined with quad-shot radiotherapy was feasible and achieved a 47% response rate in patients with recurrent or metastatic #HeadAndNeckCancer, warranting further randomized trials. ja.ma/4xyOYG9

Figure 2. Kaplan-Meier Curves of Survival Outcomes. Two graphs: A) Progression-free survival shows probability dropping from 1.0 to 0 over 27.5 months, with patients at risk from 20 decreasing to 0. B) Overall survival probability drops from 1.0 to 0 over 29 months, patients at risk from 20 decreasing to 0.

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JAMA Otolaryngology @jamaotolaryngology.com · 19/06/2026

Machine learning models in #TongueCancer surgery provided individualized prediction of major 30-day complications, including bleeding, surgical site infection, and pneumonia, with performance comparable to ACS-NSQIP. ja.ma/4eQu3H4

Figure 2. Bar Charts Showing Risk Stratification of Outcome-Specific Models on the Independent Test Set. Chart A: Any complication. Chart B: Bleeding and transfusion. Both charts show observed event rates (bars) & mean predicted risks (line/dots) increasing across Very Low to High risk bins for an XGB model.

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JAMA Otolaryngology @jamaotolaryngology.com · 19/06/2026

Machine learning–generated #SyntheticCT from temporal bone #MRI enabled visualization of bony structures without radiation and was rated suitable for localization and preoperative planning in many otologic applications. ja.ma/4ewwWLE

Box plot shows Likert score differences for 12 anatomical landmarks, ranging from -3 (True CT score higher) to 3 (Synthetic CT score higher). Most landmarks cluster around 0, indicating similar scores. Short process incus significantly favors True CT, while Facial nerve canal (mastoid) slightly favors Synthetic CT.

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JAMA Otolaryngology @jamaotolaryngology.com · 16/06/2026

Among patients aged 16 to 65 years with recurrent or chronic tonsillitis, recovery time did not differ significantly between intracapsular and extracapsular tonsillectomy. ja.ma/4a486l5

JAMA Otolaryngology study on tonsillectomy recovery. 172 patients (mean 26.7y) in Finland with chronic tonsillitis. Three intervention groups (ECTE, ICTEc, ICTEm) showed no significant difference in recovery. Mean recovery: ECTE 12.1d, ICTEc 11.1d, ICTEm 10.3d.

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JAMA Otolaryngology @jamaotolaryngology.com · 14/06/2026

A 41-year-old male presented with a 3-month history of recurrent sore throat, intermittent fever, and yellow, purulent sputum. What is your diagnosis? ja.ma/4emPLkI

Two axial scans of the neck. (A) CT shows soft tissue & bone structures with a lesion and enhanced vessels. (B) Postcontrast T1-weighted MRI reveals low signal intensity and bone destruction in the thyroid, cricoid, & arytenoid cartilage.

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JAMA Otolaryngology @jamaotolaryngology.com · 13/06/2026

A 58-year-old woman presented with a 2-day history of sore throat and progressive right-side pharyngeal discomfort. Endoscopic examination revealed a smooth submucosal mass in the right peritonsillar region with visible pulsation. What is your diagnosis? ja.ma/4uy20AQ

A: Endoscopy of oropharynx shows a reddish, irregular, swollen tissue inside the throat with visible vessels and reflective spots. B: Axial CT of neck shows a large, dark, circular mass on the left, displacing adjacent structures. White areas represent bone.

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JAMA Otolaryngology @jamaotolaryngology.com · 12/06/2026

A 63-year-old man presented with an indurated submucosal lesion with overlying taut, blanched mucosa and surrounding erythema on the posterior ventral aspect of the right side of the tongue. What is your diagnosis? ja.ma/4xlAaKI

A: Clinical photo of a person's open mouth, extended tongue shows a red/yellow lesion. B: H&E stain of tongue lesion, revealing dense pink tissue with scattered purple cellular nuclei and inflammatory cells.

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JAMA Otolaryngology @jamaotolaryngology.com · 11/06/2026

Among children with cleft palate repaired before age 15 months, later surgical timing was associated with modest increases in passive cleft speech characteristics at age 36 months. ja.ma/4okmrjl

JAMA Otolaryngology-Head & Neck Surgery article: "Palate Repair Timing Under Age 15 Months and Early Speech Outcomes" by Katelyn Kotlarek, Kazlin Mason, Amy Davies et al. Published Online: June 11, 2026. Doi: 10.1001/jamaoto.2026.1404.

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JAMA Otolaryngology @jamaotolaryngology.com · 07/06/2026

Exposure to traffic-related #NO2, benzene, and lead was associated w/ higher risk of chronic rhinosinusitis (#CRS) and distinct sinonasal cytokine profiles, with NO2 linked to type 2 inflammation and benzene/lead to innate and neutrophilic immune markers. ja.ma/4oc8kwo

Figure 3: Predicted mean IL levels vs. standardized NO₂. Panel A (IL-4, pg/mL): Participants with CRS (orange line) show a sharp rise in IL-4 from standardized NO₂ 0.5 to 2.5. Control participants (grey line) maintain consistently low IL-4 levels. Panel B (IL-5) is partially visible.

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JAMA Otolaryngology @jamaotolaryngology.com · 07/06/2026

A 41-year-old male presented with a 3-month history of recurrent sore throat, intermittent fever, and yellow, purulent sputum. What is your diagnosis? ja.ma/49JXPul

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JAMA Otolaryngology @jamaotolaryngology.com · 07/06/2026

In a nationwide study of patients with #CRSwNP, cumulative oral corticosteroid exposure above 90 days or 1.0 g annually was associated with greater risk of systemic adverse events, particularly bone, infection, and cardiometabolic complications. ja.ma/4ajfkSj

JAMA Otolaryngology–Head & Neck Surgery article: "Oral Corticosteroids and Adverse Events in Chronic Rhinosinusitis With Nasal Polyps" by Seojin Moon, Myeongjee Lee, Inkyung Jung, et al. Published online June 4, 2026. doi: 10.1001/jamaoto.2026.1188.

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JAMA Otolaryngology @jamaotolaryngology.com · 06/06/2026

A 20-year-old male presented with a 5-month history of large, painful, multifocal oral ulcers involving the vermillion of the right upper lip and the upper-right labial vestibule. What is your diagnosis? ja.ma/4dQTxnj

Image A: Clinical photo of a red, ulcerated oral lesion in the upper-right labial vestibule, held by blue-gloved fingers. Image B: Hematoxylin and eosin stain shows a tumor infiltrating skeletal muscle in a swirling pink and purple pattern at low power (x40).

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JAMA Otolaryngology @jamaotolaryngology.com · 05/06/2026

In patients with #HNC, greater neighborhood socioeconomic deprivation was associated with lower #cancer-specific quality of life before starting treatment, especially for eating and swallowing symptoms. ja.ma/4obh0Dg

JAMA Otolaryngology-Head & Neck Surgery Original Investigation: "Patient-Reported Quality of Life and Socioeconomic Disadvantage Among Patients With Head and Neck Cancer." By K. Leonard, S. Tam, A.M. Williams et al. Published June 4, 2026.

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JAMA Otolaryngology @jamaotolaryngology.com · 04/06/2026

Article title: Oral Corticosteroids and Adverse Events in Chronic Rhinosinusitis With Nasal Polyps. Authors: Seojin Moon, Myeongjee Lee, Inkyung Jung, et al. Published in JAMA Otolaryngology-Head & Neck Surgery, June 4, 2026. DOI: 10.1001/jamaoto.2026.1188

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JAMA Otolaryngology @jamaotolaryngology.com · 01/06/2026

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JAMA Otolaryngology @jamaotolaryngology.com · 01/06/2026

In cognitively normal older adults, poorer speech-in-noise ability was associated with faster cortical thinning in speech-processing networks, suggesting value in central auditory assessment for early risk detection. ja.ma/4nXwQky

Figure 3. Box plots showing Superior Temporal Gyrus (STG) thickness in mm by hearing status (HA, Unaided HL, NH). Each plot shows a box, whiskers, and individual data points. An illustration of a brain with the STG highlighted in blue is positioned above the plots.

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JAMA Otolaryngology @jamaotolaryngology.com · 25/05/2026

Figure 3 shows cumulative event incidence plots of locoregional(A) & distant recurrence(B) by patient smoking history. The y-axis represents rate of recurrence (%), x-axis is years. Never or light smokers are shown in blue, heavy smokers are in orange.

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JAMA Otolaryngology @jamaotolaryngology.com · 24/05/2026

Hypoglossal nerve stimulation therapy for #ObstructiveSleepApnea significantly reduced hypoxic burden, with improvements in sleepiness associated with HB reduction—independent of AHI changes. ja.ma/4uvbnCf

Figure 1 shows sleep apnea-specific hypoxic burden, with two graphs: A) Airflow, displaying nasal pressure over time, highlighting 'Apnea', and B) Oxygen saturation (SpO2, %) fluctuating between 85 and 95% over time.

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JAMA Otolaryngology @jamaotolaryngology.com · 23/05/2026

The adaptive SNOT instrument for #ChronicRhinosinusitis demonstrated internal consistency, reliability, and responsiveness, distinguishing patients by sinus CT findings and correlating with global health scores. ja.ma/3PGvWMP

JAMA Otolaryngology article: "Validation of an Adaptive Sinonasal Outcome Test" by Selena K. Zhang, BS@1, Sapideh Gilani, MD@2, Ayako Stanlie, MD@3, et al. Published May 14, 2026. doi: 10.1001/jamaoto.2026.1008.

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