This narrative review discusses the hallmark magnetic resonance imaging (MRI) features of optic nerve, brain, and spinal cord involvement in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), the recommended MRI protocol for acute attacks, the timing and utility of repeating...

This narrative review discusses an alternative approach to disease classification based on underlying pathobiology, specifically examining the role of transactive response DNA-binding protein, 43 kDa ...

This cross-sectional study evaluates the performance of the US Food and Drug Administration–cleared phosphorylated tau 217 (p-tau217) to β-amyloid 42 ratio cut points used to detect amyloid pathology associated with Alzheimer disease.

This study evaluates the quantile-aggregation method using both simulated data and publicly available Alzheimer disease randomized trial data.

This case report describes delayed hemichorea-dystonia following right carotid endarterectomy for proximal internal carotid artery stenosis in a 79-year-old man.

This case report describes a 58-year-old man with a 10-day history of left eye redness, proptosis, blurred vision, and left-sided head pressure.

This review discusses the most recent progress in genetic therapies for gliomas, with a focus on clinical platforms and those nearing clinical translation.

This cross-sectional study investigates how genetic variants and neuropathology are associated with clinical features and diagnostic accuracy in movement disorders.

This randomized clinical trial evaluates whether a reperfusion-guided systolic blood pressure control strategy improves functional outcomes compared with guideline-recommended management after successful endovascular therapy for acute ischemic stroke.

This cross-sectional study among 2 independent cohorts investigates the clinical associations of cerebrospinal fluid TMEM106B protein levels in frontotemporal lobar degeneration.

This randomized clinical trial attempts to determine whether standard-dose tenecteplase at 0.25 mg/kg achieves a higher rate of recanalization on the initial angiogram than low-dose alteplase at 0.6 mg/kg in patients scheduled for mechanical thrombectomy.

This randomized clinical trial evaluates whether n-butyl cyanoacrylate for middle meningeal artery embolization plus standard of care reduces the residual or re-accumulation of hematoma compared with standard of care alone.

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Interview with Kelly G. Gwathmey, MD, author of Efficacy and Safety of Gefurulimab in Generalized Myasthenia Gravis: The PREVAIL Phase 3 Randomized Clinical Trial. Hosted by Cynthia E. Armand, MD.

Parkinson disease (PD) affects over 11 million people worldwide and is among the fastest-growing causes of neurological death and disability.1 This trend highlights the critical need to identify and address modifiable risk factors of PD. Several environmental chemicals have been linked to PD risk,...

This cohort study evaluates the association between long-term exposure to road traffic noise and risk of Parkinson disease.

In generalized myasthenia gravis (gMG), a continuously increasing spectrum of immunomodulatory agents with different mechanisms of action have been studied, including T- and B-cell directed drugs and drugs acting on downstream antibody-metabolism, such as neonatal Fc receptor (FcRn) and complement...

This randomized clinical trial compares the novel dual-binding nanobody gefurulimab vs placebo for treating anti–acetylcholine receptor antibody–positive generalized myasthenia gravis.

This Viewpoint discusses neurologists writing letters on patients’ behalf for legal proceedings.