Reposted by Jahn Zhong
We created one of the largest antibody bottom-up proteomics datasets to query the impact of experimental and computational parameters on the reconstruction of antibody sequences. www.biorxiv.org/content/10.1... Brilliant work by @mchernigovskaya.bsky.social, Khang Le Quy and Igor Snapkow.
biorxiv.org
Systematic benchmarking of mass spectrometry-based antibody sequencing reveals methodological biases
The circulating antibody repertoire is crucial for immune protection, holding significant immunological and biotechnological value. While bottom-up mass spectrometry (MS) is the most widely used prote...
