iiinova — where your digital self keeps evolving

Jacob Kimmel @jacobkimmel.bsky.social · 25/02/2026

the best history reads like fiction, the best fiction reads like history

Jacob Kimmel @jacobkimmel.bsky.social · 20/11/2025

biology is often plagued with irreducible latencies. accelerating progress then requires increasing bandwidth, parallelizing many experiments. prior generations optimized discoveries/hypothesis tested with elegant, serial iteration. ours will optimize discoveries/unit time.

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Jacob Kimmel @jacobkimmel.bsky.social · 06/05/2025

we're entering a new phase @newlimitbio.bsky.social & beginning to progress our first medicines for aging & disease. now more than ever, we're confident that reprogramming biology will unlock more healthy years in each life. it's a privilege to build this future with generational partners.

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Jacob Kimmel @jacobkimmel.bsky.social · 04/05/2025

health is both the most valuable commodity & a Jevons good. the more healthy years/$ you can buy, the more total health spending will *increase*. there's no upper bound on value for therapeutic & enhancement products that really work.

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Jacob Kimmel @jacobkimmel.bsky.social · 11/04/2025

close to heaven, could only be better with tartine bread

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Jacob Kimmel @jacobkimmel.bsky.social · 27/03/2025

Noam is a hero. It’s a shame there are no good books about him. “Man who fed the world” doesn’t do him justice.

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Jacob Kimmel @jacobkimmel.bsky.social · 23/03/2025

each year @newlimitbio.bsky.social, we share an update on our progress with the public this week, we revealed the early results from our programs in metabolism & immunology. we’re starting to see the first hints of reprogramming medicines on the horizon. watch here: m.youtube.com/watch?v=HR0-...

m.youtube.com

NewLimit Progress Update 2025

YouTube video by NewLimit

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Jacob Kimmel @jacobkimmel.bsky.social · 14/03/2025

early winter @newlimitbio.bsky.social: - +3 TF sets with efficacy in animal disease models - +3 TF sets that restore youthful function in old T cells - 20X increase in humanized liver screening throughput - 2X better in silico reprogramming than the best baseline details: bit.ly/4iuBvqC

blog.newlimit.com

January // February 2025 Progress Update

Therapeutic beginnings

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Jacob Kimmel @jacobkimmel.bsky.social · 01/03/2025

cognitive drills are substantially underrated in molecular biology & genomics half of creativity is having the ingredients for invention top of mind building a Borgesian mental library of enzymes & reactions pays dividends

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Jacob Kimmel @jacobkimmel.bsky.social · 14/01/2025

thanks for sharing, reached out :)

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Jacob Kimmel @jacobkimmel.bsky.social · 09/01/2025

2024 @newlimitbio.bsky.social: - 10X Engine throughput - Discovered TF sets that reprogram cell age & preserve type - Restored youthful function in a disease model with drug-like reprogramming we demonstrated that reprogramming medicines are possible 2025: we start to develop them bit.ly/4h7rrD3

bit.ly

2024 Year in Review

Restoring youthful function

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Reposted by Jacob Kimmel

Anshul Kundaje @anshulkundaje.bsky.social · 08/01/2025

Congrats to Johannes Linder, David Kelley et al. on the journal publication of Borzoi - a long context sequence models of RNA-seq coverage profiles with many nice applications for transcriptional & post-transcriptional regulation & variant effect prediction. www.nature.com/articles/s41... 1/

nature.com

Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation - Nature Genetics

Borzoi adapts the Enformer sequence-to-expression model to directly predict RNA-seq coverage, enabling the in-silico analysis of variant effects across multiple layers of gene regulation.

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Jacob Kimmel @jacobkimmel.bsky.social · 03/01/2025

this is gorgeous! any trick to spotting these events?

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Jacob Kimmel @jacobkimmel.bsky.social · 23/12/2024

would love to meet while you’re in town for hotels, South SF is probably a good 80/20. mostly oriented toward biotech travelers & ~15’ from downtown.

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Jacob Kimmel @jacobkimmel.bsky.social · 09/12/2024

the Sound Life Cohort from Allen Immunology has 100+ patients for PBMCs. Unfortunately I don’t think there are any multi-tissue unified efforts at that scale yet, so the best data available today might need to integrate across studies.

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Jacob Kimmel @jacobkimmel.bsky.social · 05/12/2024

zenodo wrapped: which supplemental methods did you most rely upon 🙂

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Jacob Kimmel @jacobkimmel.bsky.social · 29/11/2024

excited to dig into this, congratulations to the team 🎉

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Jacob Kimmel @jacobkimmel.bsky.social · 27/11/2024

obesity installs an epigenetic memory that persists even after weight loss this memory makes animals gain weight again rapidly -- maybe part of why dieting is insufficient imagine we'll see reprogramming medicines to restore healthy, youthful function in these cells over time

nature.com

Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature

Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...

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Jacob Kimmel @jacobkimmel.bsky.social · 23/11/2024

we remodeled also @newlimitbio.bsky.social hq. we stole design ideas from bell labs & skunk works, then added glass everywhere to mimic the future we're trying to build. we're all excited for the discoveries to come in our new space.

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Jacob Kimmel @jacobkimmel.bsky.social · 23/11/2024

we've previously discovered TF sets that reverse T cell age using a phenotypic approach. for each TF set, we ask if it makes old T cells "look" younger based on gene expression. last month, we developed our 1st functional screening system that directly measures the impact of 100s of TF sets at once

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Jacob Kimmel @jacobkimmel.bsky.social · 23/11/2024

discovering TF sets that reverse cell age is only the first step to making a medicine. next, we'll need to formulate these TF sets into drugs. @newlimitbio.bsky.social is leveraging LNP-mRNA technology to achieve this, similar to the COVID vaccines.

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Jacob Kimmel @jacobkimmel.bsky.social · 23/11/2024

our Metabolism team developed 2 gold-standard pre-clinical models for hepatocytes. consistent with our previous results, old hepatocytes are more susceptible to damage than young in both settings.

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Jacob Kimmel @jacobkimmel.bsky.social · 23/11/2024

We've ported our Engine technology to human hepatocytes and received our first in vivo screening results to our knowledge, these are the first in vivo screening data for human hepatocytes & the first 70 reprogramming sets tested to date. already we're seeing promising signals.

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Jacob Kimmel @jacobkimmel.bsky.social · 23/11/2024

early autumn @newlimitbio.bsky.social: - 0 → 70 TF sets tested in human hepatocytes via a chimeric liver system - +2779 TF sets tested in T cells - +51 sets that reverse phenotypic age in T cells - 5 → 7 functional assays for hepatocyte age - 0 → 80% efficiency LNP-mRNA delivery bit.ly/4g0NKJV

blog.newlimit.com

September // October 2024 Progress Update

In chimerico reprogramming

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Jacob Kimmel @jacobkimmel.bsky.social · 13/11/2024

jacob let’s be honest we all know you mostly use fruits

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Jacob Kimmel @jacobkimmel.bsky.social · 09/09/2023

late summer @newlimit - world's largest partial reprogramming screen (again) - 3x'd speed of sequencing turn-around - 5x'd reprog factor library size - built our first integrated reprog corpus for model training - team += 3 blog.newlimit.com/p/july-augus...

blog.newlimit.com

July-August 2023 Progress Update

Recursive record setting

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