Reposted by Jackrel Lab
Online Now: Matrin-3 forms spherical and wormlike assemblies that are modulated by RNA binding and ALS/FTD-associated mutations Online now:
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Matrin-3 forms spherical and wormlike assemblies that are modulated by RNA binding and ALS/FTD-associated mutations
Sprunger et al. have characterized the intrinsically disordered protein Matrin-3, which is implicated in amyotrophic lateral sclerosis (ALS). They find that Matrin-3 forms unusual nanoscale spherical and wormlike assemblies that undergo reversible and concentration-dependent transitions. RNA binding and ALS-associated mutations are key modulators of these assemblies.