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Tempera_Lab

@itphilly.bsky.social
53 followers 83 following 5 posts

We’re a virology and chromatin lab digging into how Epstein-Barr Virus (EBV) rewires the host cell to cause cancer. We mix epigenetics, 3D genome biology, and metabolism to figure out how it all works—and how to stop it.

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Tempera_Lab @itphilly.bsky.social · 10/02/2026
Excited to share our new study: Integrated transcriptomic and methylome analysis reveals retinoic acid pathway activation after decitabine treatment in EBV-associated gastric cancer | mBio #EBV #Epigenetics #CancerResearch #GastricCancer #DNAme #Transcriptomics journals.asm.org/doi/10.1128/...
journals.asm.org
Integrated transcriptomic and methylome analysis reveals retinoic acid pathway activation after decitabine treatment in EBV-associated gastric cancer | mBio
EBV+ gastric cancer contains hypermethylated DNA, and despite this distinct molecular phenotype, there are currently no Epstein–Barr virus (EBV)-specific treatments available. Using an FDA-approved in...
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Tempera_Lab @itphilly.bsky.social · 16/01/2026
Honored and grateful to be promoted to Professor. Thank you to the mentors, colleagues, students, and collaborators who made this possible.
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Tempera_Lab @itphilly.bsky.social · 21/10/2025
🧬 New from our Lab! Integrated transcriptomic + methylome profiling reveals that Decitabine activates the retinoic acid pathway in EBV-associated gastric cancer, uncovering how DNA demethylation reshapes viral–host signaling. #Epigenetics #EBV #CancerResearch www.biorxiv.org/content/10.1...
biorxiv.org
Integrated transcriptomic and methylome analysis reveals retinoic acid pathway activation after decitabine treatment in EBV associated gastric cancer
Epstein-Barr virus associated gastric cancer (EBVaGC) accounts for ∼9–10% of gastric cancers worldwide and is defined by a distinctive molecular profile, including extreme hypermethylation of the DNA....
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Tempera_Lab @itphilly.bsky.social · 13/07/2025
We are excited to share our recent work: EBNA leader protein orchestrates chromatin architecture remodeling during Epstein-Barr virus-induced B cell transformation url: academic.oup.com/nar/article/...
academic.oup.com
EBNA leader protein orchestrates chromatin architecture remodeling during Epstein-Barr virus-induced B cell transformation
Abstract. Epstein-Barr virus Nuclear Antigen Leader Protein (EBNA-LP) plays a pivotal role in the transformation of B cells by Epstein-Barr virus (EBV), fu
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Katie Phang @katiephang.bsky.social · 17/11/2024
RFK Jr.: “Thank you [to the NIH] for public service. We’re going to give infectious disease a break for about eight years.” Kennedy wants to take a “break” from studying infectious diseases like COVID-19 and measles. www.nbcnews.com/politics/pol...
nbcnews.com
RFK Jr. comes ‘home’ to his anti-vaccine group, commits to ‘a break’ for U.S. infectious disease research
He has suggested without evidence that researchers and pharmaceutical companies are driven by profit to neglect chronic conditions.
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