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UPENN_ITMAT @itmat.bsky.social · 08/10/2026

Clock-Dependent Organoid Maturation by Daily Metabolic Cycling by Juan Alvarez, PhD, Assistant Professor of Cell and Developmental Biology @juanalvarezdom.bsky.social @PennMedicine #ITMATSymposium2026 #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 08/10/2026

Reception and Dinner: The College of Physicians of Philadelphia with Dinner Discussant: Norman J. Ornstein Retired Scholar, American Enterprise Institute @NormOrnstein @PennMedicine #ITMATSymposium2026 #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 08/10/2026

An (un)easy Marriage: Academic-Biotech Partnerships in Translational Research by Saar Gill, MD, PhD, Scientific Co-Director, Cell Therapy and Transplant Program, Professor of Medicine @PennMedicine #ITMATSymposium2026 #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 08/10/2026

Outsmarting the Escape Artist: Resistance to CART Immunotherapies for Lymphoid Malignancies by Marco Ruella, MD, Associate Professor of Medicine @MarcoRuella @PennMedicine #ITMATSymposium2026 #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 08/10/2026

The Journey of CAR T Cells from HIV to Cancer to Autoimmunity by Carl June, MD, Richard W. Vague Professor in Immunotherapy @carlhjune @PennMedicine #ITMATSymposium2026 #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 08/10/2026

From n=1 to n-many: Developing Scalable Genetic Medicines for Rare Disease by James Dowling, MD, PhD, Director, Penn Neurogenetics Therapy Center, Ruth Wagner Van Meter & J. Ray Van Meter Professor of Neurology @PennMedicine #ITMATSymposium2026 #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 08/10/2026

Emerging Neurodegenerative Disease Therapies: Targeting Proteinopathies by Edward B. Lee, MD, PhD, John Q. Trojanowski, MD, PhD Professor for Neurodegenerative Disease Research @PennMedicine #ITMATSymposium2026 #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 08/10/2026

Islet Cell Sources for Transplantation in Type 1 Diabetes by Michael R. Rickels, MD, MS, Willard and Rhoda Ware Professor in Diabetes & Metabolic Diseases @PennMedicine #ITMATSymposium2026 #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 08/10/2026

Alchemy for this Moment: Turning Challenges into Opportunities by Nancy Andrews, MD, PhD, EVP, CSO, Helen M. Ranney, M.D. Chair, Boston Children’s Hospital, Professor in Residence of Pediatrics, Harvard Medical School @PennMedicine #ITMATSymposium2026

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UPENN_ITMAT @itmat.bsky.social · 08/10/2026

Turning Genes into Medicines by Katherine High, MD, CEO, RhyGaze; Visiting Professor, Rockefeller University; Professor Emeritus, Perelman School of Medicine of the University of Pennsylvania; Founding Director, Center for Cellular and Molecular Therapeutics, Children’s Hospital of

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UPENN_ITMAT @itmat.bsky.social · 08/10/2026

From Fantasy to Reality: Harnessing Genes to Reverse Blindness by Jean Bennett, MD, PhD, F.M. Kirby Professor Emerita, Ophthalmology @PennMedicine #ITMATSymposium2026 #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 08/10/2026

mRNA CAR T Cells to Treat Fibrosis by Jonathan Epstein, MD, Dean, Perelman School of Medicine, Executive Vice President @JonEpsteinLab @PennMedicine #ITMATSymposium2026 #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 08/10/2026

Advancing Genome Editing Therapies for Rare Diseases by Rebecca Ahrens-Nicklas, MD, PhD, Associate Professor of Pediatrics@@AhrensNicklas @PennMedicine #ITMATSymposium2026 #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 08/10/2026

Nucleoside-Modified mRNA-LNP Therapeutics by Drew Weissman, MD, PhD, Roberts Family Professor in Vaccine Research @WeissmanLab @PennMedicine #ITMATSymposium2026 #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 08/10/2026

Welcome address by Jonathan Epstein, MD, Dean, Perelman School of Medicine, Executive Vice President @JonEpsteinLab @PennMedicine #ITMATSymposium2026 #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 08/10/2026

Welcome to the ITMAT 21st Annual International Symposium "Intermezzo; 20 Years of Translational Therapeutics at PENN and CHOP"

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UPENN_ITMAT @itmat.bsky.social · 21/07/2026

WHERE ART AND SCIENCE MEET: community still life + student showcase. ITMAT Education invites you to draw, observe and reflect this Thursday from 5-7 PM at the Institute of Contemporary Art, RSVP required, virtual option available, details on flyer

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UPENN_ITMAT @itmat.bsky.social · 02/07/2026

Happy 4th of July and 250th Anniversary!

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UPENN_ITMAT @itmat.bsky.social · 04/04/2026

A genotype-first framework aimed at defining #CoronaryMicrovascularDisease as an often overlooked and insufficiently treated cause of #IschemicHeartDisease www.ahajournals.org/doi/epdf/10.... @marieguerraty #CMVD #ChestPain #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 03/02/2026

#1 in Medical Breakthroughs: Seven of the top 20 papers honored by the Clinical Research Forum (CRF) are from Penn @CRForumUS #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 06/01/2026

Happy New Year from ITMAT!

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UPENN_ITMAT @itmat.bsky.social · 25/11/2025

Wishing you a joyful and restful Thanksgiving!

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UPENN_ITMAT @itmat.bsky.social · 26/08/2025

Molecular insights to potentially prevent #BetaCell failure in #Type2Diabetes doi.org/10.1016/j.mo... #T2D #DiabetesResearch #IsletBiology #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 29/07/2025

#Neuropeptides essential for complex social behavior with phenotypic plasticity in social insect model doi.org/10.1016/j.ce... #SocialAnalysis #SocialHierarchy #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 24/07/2025

Join us via Zoom! Register Here: tinyurl.com/virtualTRIPICA

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UPENN_ITMAT @itmat.bsky.social · 22/07/2025

Examining mechanisms relevant for restoring #Erythropoiesis & mitigation of pro-inflammatory IFNγ action in #MouseModel #Anemia of #Inflammation (AI) doi.org/10.1182/bloo... #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 15/07/2025

You’re Invited: Where Science Meets Art: ITMAT Artist-in-Residence Ceramic Showcase on 7/24 from 5-7 PM at the Institute for Contemporary Art in Philadelphia, PA! RSVP at www.instagram.com/upenn_itmat/

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UPENN_ITMAT @itmat.bsky.social · 01/07/2025

#AdolescentBrain: #SexDifferences in the spatial organization of functional #Brain networks accentuated in association networks especially in frontoparietal & ventral attention networks doi.org/10.1192/bjp.... #MentalHealth #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 24/06/2025

How do biological systems interact with foreign materials? How is decision-making reflected in biological signaling networks? Using complement activation as a model system doi.org/10.1016/j.ce... dives into these questions @jakebrenner #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 13/06/2025

Building the foundation to address the mechanistic gap between two hallmarks of #Neurodegeneration: excitotoxicity and RNA regulation by #RNA #BindingProteins (RBPs). doi.org/10.1016/j.is... @KJSsci #NeuroSci #MolecularBiology #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 10/06/2025

Engineering genetic approaches to develop a CAR-T cell therapy efficaciously targeting #SolidTumor doi.org/10.1016/j.cc... @DJPowellLab #NeoCARs #CellTherapy #CARTCell #GeneTherapy #ImmunoTherapy #Oncology #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 01/05/2025

Waking up after #Anesthesia: Neuronal dynamics model predicts both population- and individual-level features of emergence doi.org/10.1016/j.bj... #Anaesthesia #Anesthesiology #Anaesthesiology #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 08/04/2025

Characterizing molecular programs guiding #CardioPulmonary maturation through integration of #SpatialTranscriptomics with #Computational #CellTrajectory analysis and #TranscriptionalProfiling doi.org/10.1016/j.ce... #CellAtlas #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 27/03/2025

Novel non-anticoagulant therapeutics to curb the immune response in Heparin-Induced #Thrombocytopenia #HIT doi.org/10.1182/bloo... #DrugDevelopment #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 25/03/2025

The most important test in science is the test of time: A perspective on data, fraud, trust & validity doi.org/10.1017/jme.... @FitzGerald__Lab #ScienceIntegrity #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 13/03/2025

Early nonresponse to behavioral obesity treatment doesn’t have to mean failure. Adding anti-obesity medication doubles weight loss. doi.org/10.1038/s415... #ObesityResearch #WeightLossScience #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 06/03/2025

Check this out! Monitoring the spatiotemporal dynamics of #mRNAvaccine antigen expression in vivo www.nature.com/articles/s41... @drewweissmanlab.bsky.social #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 05/03/2025

Multi-population study into genetic architecture of human #KidneyFunction discovers 124 genes amenable to targeting by FDA-approved drugs doi.org/10.1126/scie... ‪@ksusztak.bsky.social‬ @marylynritchie.bsky.social #TranslationalScience #DrugRepurposing

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UPENN_ITMAT @itmat.bsky.social · 27/02/2025

Advancing our understanding of immunogenic epitope selection, with implications for #VaccineDevelopment and T cell–based therapies. doi.org/10.1073/pnas... #CryoEM @moiseenkovabell #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 25/02/2025

Promising leads in therapeutic advances for metabolic dysfunction-associated steatotic #LiverDisease (#MASLD) doi.org/10.1016/j.cm... @WellenLab

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UPENN_ITMAT @itmat.bsky.social · 13/02/2025

Extending the #OrganOnAChip technology to mimic #BoneMarrow enabling mechanistic studies on injury models, #DrugToxicity, and more. Check out doi.org/10.1016/j.st... @PennEngineers #PennEngineering #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 07/02/2025

More ITMAT Winter Party fun!

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UPENN_ITMAT @itmat.bsky.social · 07/02/2025

Thank you to all who joined us for the ITMAT Winter Party! What a great night to come together and celebrate another fantastic year. @jonepstein1.bsky.social @pennmedicine.bsky.social @pennmedicine.bsky.social

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UPENN_ITMAT @itmat.bsky.social · 04/02/2025

Common nanoparticle linkers may hijack the #ImmuneSystem, drive toxicity and misdirect #DrugDelivery. However, @jakebrenner lab uncovers molecular mechanisms & develops solutions to mitigate these effects doi.org/10.1002/adma... #Nanomedicine #TranslationalScience

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UPENN_ITMAT @itmat.bsky.social · 28/01/2025

Refining first-in-human dual-targeting chimeric antigen receptor (CAR)-T cells for #Glioblastoma with real-time #Organoid modeling. doi.org/10.1016/j.st... #Cancer #CARTcelltherapy #TranslationalScience

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