Sign in

isabellemahe.bsky.social

@isabellemahe.bsky.social
9 followers 5 following 7 posts
PostsRepliesMedia
isabellemahe.bsky.social @isabellemahe.bsky.social · 24/05/2025
@isth.org
010
isabellemahe.bsky.social @isabellemahe.bsky.social · 23/05/2025
How do you manage oral anticoagulants in patients undergoing an invasive dental procedure? Our prospective national study suggests a short DOAC discontinuation before the invasive dental procedure can minimize bleeding! @RPTHjournal doi.org/10.1016/j.rp...
031
Reposted by @isabellemahe.bsky.social
American College of Cardiology @accintouch.bsky.social · 29/03/2025
Extended anticoagulant therapy with reduced-dose apixaban was noninferior to full-dose in patients with active cancer and #cvVTE, based on findings from the API-CAT trial presented at #ACC25. Read the journal scan to learn more: bit.ly/43w2A8v #CardioSky #MedSky
087
Reposted by @isabellemahe.bsky.social
NEJM.org @nejm.org · 29/03/2025
In the API-CAT trial involving patients with active cancer and venous thromboembolism, extended anticoagulation with reduced-dose apixaban was noninferior to full-dose apixaban for preventing recurrent thromboembolic events. Full results: nej.md/41YkRZK #ACC25 | @accintouch.bsky.social
A graph showing the cumulative incidence of recurrent venous thromboembolism (primary efficacy outcome) among patients who received apixaban at a reduced (2.5 mg) or full (5.0 mg) dose twice daily for 12 months.
1188
Reposted by @isabellemahe.bsky.social
NEJM.org @nejm.org · 13/04/2025
In the API-CAT trial involving patients with active cancer and venous thromboembolism, extended anticoagulation with reduced-dose apixaban was noninferior to full-dose apixaban for preventing recurrent thromboembolic events. Full trial results and Research Summary: nej.md/41YkRZK #MedSky
The New England Journal of Medicine    
Extended Reduced-Dose Apixaban for Cancer-Associated VTE 
A Research Summary based on Mahé I et al. | 10.1056/NEJMoa2416112 | Published on March 29, 2025 

Visual representations of the patients in the trial and the treatments they were assigned.        

Read the full Research Summary at NEJM.org.
0216
isabellemahe.bsky.social @isabellemahe.bsky.social · 14/04/2025
#API-CAT study by the #nejm.org. #accintouch.bsky.social #isth.org #apixaban #VTE #cancer
000
Reposted by @isabellemahe.bsky.social
NEJM.org @nejm.org · 12/04/2025
Patients with cancer and VTE are at risk for VTE recurrence, and there are limited data on appropriate and effective anticoagulation regimens beyond 6 months. Findings from the API-CAT trial are summarized in a short video.
youtu.be
Reduced-Dose Apixaban for Cancer-Associated VTE (API-CAT Trial) | NEJM
Patients with cancer and VTE are at risk for VTE recurrence, and there are limited data on appropriate and effective anticoagulation regimens beyond 6 months...
0146
isabellemahe.bsky.social @isabellemahe.bsky.social · 14/04/2025
#API-CAT study by the @nejm.org. @accintouch.bsky.social @isth.org #apixaban #VTE #cancer
010
Reposted by @isabellemahe.bsky.social
Dr Martha Gulati @drmarthagulati.bsky.social · 29/03/2025
#APICAT trial at #ACC25 #LBCT #cardioonc 🩸apixaban low 2.5 mg vs full dose 5mg in patients with cancer+VTE: primary endpoint recurrent VTE 🩸more than half female! 👏🏽👏🏽 🩸the low dose was significant for noninferiority for efficacy & ⤵️ bleed 🩸no increase in deaths
33020
Reposted by @isabellemahe.bsky.social
Institut du Cancer AP-HP. Nord @cancerparisnord.bsky.social · 01/04/2025
Une étude majeure dans la prise en charge des patients atteints de cancer et traités pour un événement thromboembolique veineux, deuxième cause de décès, a été menée et coordonnée par la Pr Isabelle Mahé, cheffe du service de médecine interne de @hoplouismourier.bsky.social A découvrir ici 👇
041
Reposted by @isabellemahe.bsky.social
Assistance Publique – Hôpitaux de Paris (AP-HP) @ap-hp.bsky.social · 31/03/2025
🔬 Pour la première fois, une étude démontre que la dose réduite d'un anticoagulant oral est aussi efficace que la dose pleine et réduit le risque hémorragique de 25% pour les patients atteints de #cancer traités pour thrombose veineuse ou embolie pulmonaire Découvrez les résultats 👉 swll.to/sOSmEZC
064
Reposted by @isabellemahe.bsky.social
jeanconnorsmd.bsky.social @jeanconnorsmd.bsky.social · 29/03/2025
@acc25.bsky.social Isabelle Mahe presents API-CAT Low dose Apixaban noninferior to high dose for recurrent VTE and superior for lower bleeding-another win!
093
Reposted by @isabellemahe.bsky.social
JACC Journals @jaccjournals.bsky.social · 29/03/2025
Dr. Isabelle Mahe on the extended anticoagulant treatment with a reduced versus full dose #apixaban in patients with cancer-associated #VTE #ACC25 #JACCJournals #APICAT #CardioOnc #cvCoag #CardioSky
174
Reposted by @isabellemahe.bsky.social
kirolloskamel.bsky.social @kirolloskamel.bsky.social · 30/03/2025
Finally! More data to add to the EVE trial APICAT showed non inferiority of apixaban 2.5BD in patients with CAVTE who have completed 6m anticoagulation to 5BD in terms of VTE recurrence (2.1% v 2.8%) and lower clinically relevant bleeding (12.1% v 15.6%) #Hemesky #BSH www.nejm.org/doi/full/10....
nejm.org
Extended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism | NEJM
In patients with active cancer and venous thromboembolism, whether extended treatment with a reduced dose of an oral anticoagulant is effective in preventing recurrent thromboembolic events and dec...
131
isabellemahe.bsky.social @isabellemahe.bsky.social · 01/04/2025
@acc2025.bsky.social @jaccjournals.bsky.social
021
isabellemahe.bsky.social @isabellemahe.bsky.social · 01/04/2025
The article published in the @NEJM.org can be accessed.see below Citation: Mahé I, Carrier M, Didier M, et al. Extended reduced-dose apixaban for cancer-associated venous thromboembolism. NEJM. Published online March 29, 2025. Doi: 10.1056/NEJMoa2416112
021
Reposted by @isabellemahe.bsky.social
Marc Carrier, MD @marccarriermd.bsky.social · 29/03/2025
Prof. @isabellemahe.bsky.social presents API-CAT at @accintouch.bsky.social published in @nejm.org: Extended anticoagulation with reduced-dose apixaban is noninferior to full-dose for preventing recurrent VTE, with less clinically relevant bleeding 🩸in cancer patients www.nejm.org/doi/full/10....
0109
Reposted by @isabellemahe.bsky.social
RPTH @rpth.bsky.social · 02/03/2025
Regulatory agencies have issued warnings about JAK inhibitors and VTE risk—but what does the evidence actually say? Our latest review breaks down the data, limitations, and next steps. @davidmsmadja.bsky.social @isabellemahe.bsky.social 📑 Read now: buff.ly/4ijJQNq
055
isabellemahe.bsky.social @isabellemahe.bsky.social · 26/02/2025
The #VTE risk associated with #JAKi in #inflammatory diseases has been suggested, followed by precautionary measures by health authorities. This literature review illustrates that available data on VTE risk on JAKi are conflicting and inconclusive @DavidMSmadja @RPTHjournal doi.org/10.1016/j.rp...
032