Delighted to share our latest publication in Advanced Science, where we show that hypersialylation is a key feature of intervertebral disc degeneration and that inhibiting this glycosylation change can modulate inflammatory and metabolic pathways.
doi.org/10.1002/advs...
doi.org
Inhibition of Hypersialylation in Human Intervertebral Disc Degeneration Modulates Inflammation and Metabolism
Glycosylation, specifically hypersialylation, is identified as a critical factor in human intervertebral disc (IVD) degeneration—a major cause of low back pain. This study demonstrates that inhibitin....