iiinova — where your digital self keeps evolving

IonOptix @ionoptix.bsky.social · 18/05/2026

Researchers used the IonOptix MyoStretcher and MultiCell to show that inhibiting RBM20 reduces titin stiffness and improves diastolic function. Inducing compliant titin isoforms offers a novel therapeutic strategy for HFpEF. 🫀 Full study: shorturl.at/hj8T8

010

IonOptix @ionoptix.bsky.social · 05/05/2026

Researchers used our MultiCell System to evaluate cardiac contractility after cLNP-mediated RNA delivery. This study highlights a novel systemic approach to target the heart while bypassing liver uptake, validated by high-content functional data. shorturl.at/nbKMM

020

IonOptix @ionoptix.bsky.social · 23/03/2026

Work Loop Power Analysis lets you quantify mechanical work in myocardial slices. Using IonWizard, force‑length loops reveal key parameters of heart function, linking measurements to physiological and pathological conditions. Learn more: tinyurl.com/4kznha2r

tinyurl.com

Work Loop Power Analysis - IonOptix

Work Loop Power Analysis: Mechanical work in myocardial slices

110

IonOptix @ionoptix.bsky.social · 10/03/2026

A recent study links N-terminal acetylation dysregulation to cardiac arrhythmia and cardiomyopathy. Using patient-derived iPSC-CMs and the IonOptix Calcium & Contractility System, researchers uncovered how NatA mutations disrupt cardiac function. shorturl.at/onfeK

350

IonOptix @ionoptix.bsky.social · 23/02/2026

Bloodborne pancreatic amylin may impair cerebral Aβ clearance, contributing to Alzheimer's pathology. Using the IonOptix Vessel Diameter System, researchers showed how amylin affects vascular tone and Aβ pathways. shorturl.at/aH1XN

210

IonOptix @ionoptix.bsky.social · 09/02/2026

Loss of Snord116 improves cardiomyocyte performance during ischemic stress. Using living myocardial slices and the IonOptix Cardiac Slice System, researchers showed improved contractility and kinetics during ischemia–reperfusion injury. shorturl.at/nc9o0

shorturl.at

Loss of Snord116 protects cardiomyocyte kinetics during ischemic stress

Loss of Snord116, a non-coding RNA, causes Prader Willi Syndrome (PWS), a complex disorder with circadian, metabolic, neurologic, and cardiovascular p…

221

IonOptix @ionoptix.bsky.social · 26/01/2026

A Nature study shows iPSC-CM maturation can be significantly improved by combining metabolic media, nanopatterning, and electrostimulation. Using the IonOptix C-Pace, researchers achieved more adult-like structure, function, and drug response. shorturl.at/DUbfl

110

IonOptix @ionoptix.bsky.social · 21/01/2026

Stretch-mediated β₂-adrenergic signaling in cardiomyocytes depends on caveolae. Using the IonOptix CytoCypher MultiCell, researchers showed stretch increases contractility and cAMP via β₂AR—not β₁AR—and is lost when caveolae are disrupted. shorturl.at/AgbtN

120

IonOptix @ionoptix.bsky.social · 17/12/2025

Mechanical loading reveals hidden cardiomyocyte stiffness in cardiometabolic disease. Using IonOptix MyoStretcher and Calcium & Contractility systems, researchers found HFSD-fed mice had stiffer cells and slower Ca²⁺ decay—signs of diastolic dysfunction. shorturl.at/xDazR

010

IonOptix @ionoptix.bsky.social · 10/12/2025

A recent study reveals how a titin mutation alters thick filament length, driving dilated cardiomyopathy. Using the IonOptix MyoStretcher and CytoCypher MultiCell Systems, researchers measured changes in force, sarcomere length, and calcium handling. shorturl.at/H9b2r

shorturl.at

Shortening the thick filament by partial deletion of titin's C-zone alters cardiac function by reducing the operating sarcomere length range

Titin's C-zone is an inextensible segment in titin, comprised of 11 super-repeats and located in the cMyBP-C-containing region of the thick filament. Previously we showed that deletion of titin's supe...

010

IonOptix @ionoptix.bsky.social · 19/11/2025

Researchers modeled hypertrophic cardiomyopathy using human cardiac organoids derived from hiPSC-CMs carrying the MYBPC3 D389V variant. Using the IonOptix CytoCypher MultiCell System, they measured faster contractility and calcium kinetics. shorturl.at/rKqnN

000

IonOptix @ionoptix.bsky.social · 10/11/2025

In this Cardiovascular Research study, researchers used IonOptix’s MyoStretcher and MultiCell systems to assess stiffness and calcium handling in cardiomyocytes. Targeting titin isoforms via Rbm20-ASO reduced stiffness and improved diastolic function. shorturl.at/UCf89

shorturl.at

Rbm20 antisense oligonucleotides alleviate diastolic dysfunction in a mouse model of cardiometabolic heart failure (HFpEF)

AbstractAims. Heart failure with preserved ejection fraction (HFpEF) is prevalent, deadly, and difficult to treat. Risk factors such as obesity and hyperte

000

IonOptix @ionoptix.bsky.social · 05/08/2025

Researchers used IonOptix cardiomyocyte systems to study GPR41 function. Butyrate reduced cell shortening and Ca²⁺ transients in WT but not GPR41−/− mice, implicating GPR41 in modulating inotropy via cAMP signaling and SERCA2a activity. Read more: shorturl.at/9TEEr

010

Reposted by IonOptix

Solis Lab @ FSU @chrissolis.bsky.social · 03/04/2025

Such a pleasure to have Hanan from @ionoptix.bsky.social to come to FSU to help us setup this Ca2+ and contrqctility system to assess #cardiomyocyte function 🔬🧫🫀

152

Reposted by IonOptix

Carlos Henrique Pereira @carlos-henrique-p.bsky.social · 07/06/2025

Calcium transient imaging using an @ionoptix.bsky.social setup. On the bottom of the screen we can the pretty cardiomyocyte "beating". 🧪

071

IonOptix @ionoptix.bsky.social · 22/07/2025

010

IonOptix @ionoptix.bsky.social · 10/07/2025

Researchers used the IonOptix CytoCypher MultiCell to compare calcium handling and contractility in hiPSC-cardiomyocytes with or without sympathetic neurons. Coculture enhanced inotropy, chronotropy, and structure—supporting improved maturation. shorturl.at/fldct

010

IonOptix @ionoptix.bsky.social · 23/06/2025

Researchers feature IonOptix systems while highlighting the value of intact cardiomyocytes and tissue slices in HFpEF research. Preserving native environments yields more physiologically relevant insights than skinned preps. Read more: shorturl.at/bK3pU

000

IonOptix @ionoptix.bsky.social · 07/02/2025

In this Journal of Molecular and Cellular Cardiology Plus publication from researchers at UVM, Hancock et al. demonstrate a novel method utilizing living myocardial slices to model early and late stage diastole using their IonOptix Cardiac Slice System. shorturl.at/4ShI6

shorturl.at

Microtubule destabilization with colchicine increases the work output of myocardial slices

Cardiac microtubules have recently been implicated in mechanical dysfunction during heart failure. However, systemic intolerance and non-cardiac effec…

030