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IntFOLD @intfold.bsky.social · 05/08/2025

We used IntFOLD, and MultiFOLD to model interactions between Cx62 and calpain-1: "Inter-platelet communication driving thrombus formation is regulated by extracellular calpain-1 cleavage of connexin 62" | Haematologica haematologica.org/article/view...

haematologica.org

Inter-platelet communication driving thrombus formation is regulated by extracellular calpain-1 cleavage of connexin 62 | Haematologica

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Reposted by IntFOLD

Liam McGuffin @liammcguffin.bsky.social · 03/12/2024

Yesterday at #CASP16 I presented our new ModFOLDdock2 servers for the quality assessment of multimer models. It's great to see progress in the field but there are still many challenges ahead!

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Reposted by IntFOLD

Liam McGuffin @liammcguffin.bsky.social · 03/12/2024

My group members, Shaima and @recep44.bsky.social, presented their posters on MultiFOLD2 for multimer modelling and FunFOLD5 for predicting protein-ligand interactions at #CASP16. Lots of interest and positive feedback!

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Liam McGuffin @liammcguffin.bsky.social · 03/12/2024

ModFOLDdock2 is the top ranked method for predicting the interface accuracy of modelled protein complexes #CASP16. The server is available here: www.reading.ac.uk/bioinf/ModFO...

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Liam McGuffin @liammcguffin.bsky.social · 11/12/2024

The ModFOLDdock2 server is now online and freely available to all. The ModFOLDdock2 variants ranked within the top few groups at #CASP16 in QMODE1/2 metrics. ModFOLDdock2 is the best method for predicting the interface accuracy of modelled protein complexes. www.reading.ac.uk/bioinf/ModFO...

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Liam McGuffin @liammcguffin.bsky.social · 12/12/2024

Our MultiFOLD2 server is also now freely available to all. It's the top-ranked server on the hardest domain targets in #CASP16 by GDT_TS. With integrated stoichiometry prediction it outperforms AF3 on common multimer subsets in CAMEO. www.reading.ac.uk/bioinf/Multi...

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