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@incicnrs.bsky.social
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The INCI explores the nervous system and its pathologies | L'INCI explore le système nerveux et ses pathologies | @CNRS | @unistra

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@incicnrs @incicnrs.bsky.social · 17/04/2026
Notre institut recrute un ingénieur d'études (IE CNRS) - administrateur réseau en mobilité interne (NOEMIE). Merci de diffuser l'offre et de nous contacter pour toute information.
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Pierre-Eric Lutz @pelutz.bsky.social · 11/02/2026
We are looking for candidates to apply for a Marie-Curie post-doctoral fellowship to work with us on epigenomic mechanisms of addiction in humans and rodent models. More details here, please spread the word: euraxess.ec.europa.eu/jobs/hosting...
euraxess.ec.europa.eu
Epigenetic plasticity in psychiatric disease
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Pierre-Eric Lutz @pelutz.bsky.social · 06/01/2026
Now available in its final, open access form: www.sciencedirect.com/science/arti...
sciencedirect.com
The DNA methylation enzymatic machinery in substance use disorders: A systematic review
Substance use disorders (SUD) are chronic affections defined by similar symptoms across a variety of psychoactive drugs, including alcohol, cocaine, o…
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Pierre-Eric Lutz @pelutz.bsky.social · 15/11/2025
Using a prospectively registered methodology, we included and reviewed 99 articles that manipulated the enzymes or characterized DNA methylation at candidate genes, or more recently genome-wide, including in the context of in utero or developmental exposure to drugs.
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Pierre-Eric Lutz @pelutz.bsky.social · 15/11/2025
If interested in epigenomics & substance use disorders, take a look at our systematic review. We summarize current knowledge on DNA methylation & related enzymes across rodent models & drugs of abuse. Written w/ PhD student Margot Diringer & post-doc Mathieu Bruggeman www.biorxiv.org/content/10.1...
biorxiv.org
The DNA methylation enzymatic machinery in substance use disorders: a systematic review
Substance use disorders (SUD) are chronic affections defined by similar symptoms across a variety of psychoactive drugs, including alcohol, cocaine, opioids, or methamphetamine. Epigenetic mechanisms ...
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Pierre-Eric Lutz @pelutz.bsky.social · 05/11/2025
And don't hesitate to reach out if interested, in particular about mental health & neuroepigenetics. @incicnrs.bsky.social @agencerecherche.bsky.social @cnrs.fr @cnrsbiologie.bsky.social @inserm.fr @frm-officiel.bsky.social @fondationfyssen.bsky.social @procrystal.bsky.social
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Pierre-Eric Lutz @pelutz.bsky.social · 05/11/2025
The Strasbourg (France) neuroscience community (NeuroStra) will offer 3 positions over the next 3 years for junior group leaders. Applicants should develop projects along 3 themes: --> Mental health --> Neuroepigenetics --> Nociception and Pain Spread the word! neurostra.unistra.fr/actualites/a...
neurostra.unistra.fr
Junior group leader position in Strasbourg
NeuroStra aims to recruit outstanding junior scientists to develop projects aligned with the following themes: Mental health | Neuroepigenetics | Nociception and Pain
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Pierre-Eric Lutz @pelutz.bsky.social · 28/10/2025
Overall, we uncover a profound epigenetic sex divergence that mediates convergent biological dysregulation, and highlight opportunities for developing improved therapeutic strategies tailored to sex-specific mechanisms. www.biorxiv.org/content/10.1...
biorxiv.org
Sex-divergent brain epigenetic reprogramming by chronic opioids
Opioid use disorder (OUD) is a chronic condition that exhibits sex differences in prevalence, symptoms and treatment. Yet, the epigenetic mechanisms underlying these differences remain largely unknown...
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Pierre-Eric Lutz @pelutz.bsky.social · 28/10/2025
Happy to share our new preprint on opioid addiction! We profiled the multiomic consequences of chronic opioid exposure in male and female mouse brains, covering DNA methylation (using EMseq), 5 histone marks (Cut&Tag) & their transcriptional effects at bulk and cell-type-specific levels (vTRAP).
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Anne Souyris @annesouyris.bsky.social · 13/05/2025
Nous appelons à la pérennisation des Haltes Soins Addictions (#HSA), avec @alexandracordebard.bsky.social @michelerubirola.bsky.social et Alexandre Feltz. À Paris et à Strasbourg, ces dispositifs essentiels de santé publique ont montré leur efficacité, confirmée par l'Inserm et l'IGAS.
publicsenat.fr
Drogues : des élus appellent le gouvernement à pérenniser les « salles de consommation à moindre risque » par une loi - Public Sénat
Lors d’une conférence de presse au Sénat, plusieurs élus locaux et nationaux ont appelé l’Etat à se saisir de la question des Haltes Soins Addictions (HSA), ces salles de consommation et de soins pour...
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Pierre-Eric Lutz @pelutz.bsky.social · 04/04/2025
Une belle conférence de Raoul Belzeaux pour en savoir plus sur les biomarqueurs en psychiatrie : www.youtube.com/live/U23xWQv...
youtube.com
Biomarqueurs en psychiatrie : quelle perspective ? Quels défis ?
YouTube video by Bibliothèques de Marseille
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Pierre-Eric Lutz @pelutz.bsky.social · 05/02/2025
Happy to share our latest work. We analyzed 3 omic layers, DNA methylation, micro-RNAs & the transcriptome, in patients with major depressive disorder & controls. Results showed that the performance of MDD prediction increased with the number of layers considered. www.thelancet.com/journals/ebi...
thelancet.com
Using multiomic integration to improve blood biomarkers of major depressive disorder: a case-control study
Informational gain from multiomic integration had already been documented in other medical fields. Our results pave the way toward similar advances in molecular psychiatry, and have practical implicat...
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Pierre-Eric Lutz @pelutz.bsky.social · 05/02/2025
A team effort with many friends & colleagues @cnrs.bsky.social @incicnrs.bsky.social @cnrsbiologie.bsky.social @ap-hp.bsky.social @unistra.fr @univ-amu.fr @upcite.bsky.social @douglasresearch.bsky.social @univ-spn.bsky.social
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@incicnrs @incicnrs.bsky.social · 26/11/2024
New work from Tsvetan Serchov & colleagues: www.nature.com/articles/s41...
nature.com
Prefrontal cortex molecular clock modulates development of depression-like phenotype and rapid antidepressant response in mice - Nature Communications
Depression is associated with dysregulated circadian rhythms. Here, the authors show a critical role for mPFC molecular clock in regulating depression-like behavior and therapeutic potential of clock ...
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@incicnrs @incicnrs.bsky.social · 26/11/2024
New work from Hervé Cadiou & colleagues: www.frontiersin.org/journals/mol...
frontiersin.org
Frontiers | Behavioral and pharmacological characterization of planarian nociception
IntroductionPain mostly arises because specialized cells called nociceptors detect harmful or potentially harmful stimuli. In lower animals with less convolu...
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