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IDP NMR Lab

@idpnmrlab.bsky.social

8 followers 6 following 2 posts

Computational chemistry lab / Research Group of Mathematical Pharmacy at Faculty of Pharmacy, Charles University, Czech Republic

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IDP NMR Lab @idpnmrlab.bsky.social · 07/11/2025

www.sciencedirect.com/science/arti...

sciencedirect.com

Reduced binding of Tau(210–240) to BIN1: Phosphate charges prefer n-Src/distal loops over RT-Src loops

Within the disordered tangles of Tau is a proline-rich region, which is selectively targeted by the SH3 domain of BIN1, a known genetic factor for Alz…

IDP NMR Lab @idpnmrlab.bsky.social · 22/10/2025

pubs.acs.org/doi/10.1021/...

Streamlining NMR Chemical Shift Predictions for Intrinsically Disordered Proteins: Design of Ensembles with Dimensionality Reduction and Clustering

By merging advanced dimensionality reduction (DR) and clustering algorithm (CA) techniques, our study advances the sampling procedure for predicting NMR chemical shifts (CS) in intrinsically disordere...