Aim Duchenne muscular dystrophy (DMD), a rare X-linked genetic disorder, is affecting skeletal and cardiac muscles due to the loss of the dystrophin protein. Modifier proteins, whose expression is a...

Les phénomènes quantiques qui se déploient à échelle cellulaire pourraient offrir des pistes thérapeutiques pour contrer des maladies infectieuses, comme dans le cas de la Covid-19.

The decrease in male fertility observed since the beginning of the 20th century in Western countries could be linked to changes in diets and exposure …

A key challenge in development is understanding how complex organisms physically coordinate the morphogenesis of multiple tissues. Here, using biophys…

Chromatin “breathing” at DNA lesions is controlled by different waves of histone ADP-ribosylation.

imageimageThis study shows that small cell subpopulations experience transient, high-intensity mutational bursts, greatly increasing double mutation rates in wild-type yeast. These mutator episodes ar...

Increased neuronal activity of cortical pyramidal cells can paradoxically reduce cerebral blood flow via vasoconstriction mediated by glutamate and lipid messengers.

Studying cilia in human neural development is key to understanding ciliopathies. Here, using stem cell-derived human and mouse spinal organoids, the authors reveal inter-species differences for ciliop...

Dclk3 variants are risk factors for psychiatric disorders and mild cognitive impairment. Using new genetic mouse models, De Longprez et al. show that Dclk3