Excited to share the most recent preprint from our lab. We report a directed evolution platform for m6A erasers and an FTO variant with 13-fold enhanced catalytic efficiency. The FTO variant shows promoted site-specific editing efficiency of m6A in human cells. www.researchsquare.com/article/rs-7...
researchsquare.com
Directed evolution of an m6A eraser for site-selective epitranscriptome editing
N6-methyladenosine (m6A) is a critical RNA modification, but tools to manipulate it in cells remain limited. Current m6A demethylases (FTO and ALKBH5) exhibit low catalytic efficiency, hindering their...
