Antibiotic lock therapy (ALT) delivers high‐concentration antimicrobials into catheter lumens and has been proposed to prevent infections in hemodialysis (HD) patients. We conducted a systematic revie...

Clostridioides difficile infection is a common cause of clinically significant diarrhea, often becomes recurrent, and can be fatal when severe or fulminant. The purpose of this America Gastroenterological Association (AGA) Clinical Practice Update Expert Review is to provide best practice advice for C difficile infection management.

The skin is the largest, and arguably, the most vulnerable organ in the human body. Scratches and scrapes, bites and puncture wounds, impetigo and erysipelas—all these disruptions can lead to pain, sw...

The COSMOS study was a phase 2a clinical trial that showed high cure rates of genotype 1 chronic hepatitis C (CHC) and a favorable side effect profile using a 12-week regimen of simeprevir + sofosbuvi...

Acute generalized exanthematous pustulosis (AGEP) is a rare skin reaction, commonly caused by drugs. Available evidence mostly relies on small studies or case reports. We collected published AGEP case...

This clinical trial compares the efficacy of continuous vs intermittent infusion of a β-lactam antibiotic (piperacillin-tazobactam or meropenem) in decreasing all-cause mortality at 90 days in critica...

To compare the efficacy of pre-emptive antifungal therapy (PAT) and empirical antifungal therapy (EAT) in patients with febrile neutropenic acute leukaemia (AL) with/without anti-mold prophylaxis. We ...

SUMMARY Serratia species, in particular Serratia marcescens, are significant human pathogens. S. marcescens has a long and interesting taxonomic, medical experimentation, military experimentation, an...

Background Clostridium difficile infection (CDI) is an important cause of diarrhea and continues to be a major burden within healthcare institutions and in the community. For a small subset of patient...

An observational study is a type of epidemiological study design, which can take the form of a cohort, a case–control, or a cross-sectional study. When presenting observational studies in manuscripts,...

We report on 5 patients treated with MAT2203, an oral amphotericin-B formulation. MAT2203 was well tolerated and effectively treated deep tissue infections

A longer-acting formulation of cabotegravir may offer an HIV pre-exposure prophylaxis (PrEP) and treatment option that could be administered once every four months, according to early study resul...

A 29-year-old male presented with swollen gums and stomatitis for the past two months. History revealed that he had moved to the United States from India six years ago and had a first episode of gener...

Adverse drug reactions are critical considerations in managing complex medical conditions. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but potentially life-threate...

16S rRNA gene sequencing has been increasingly used in clinical practice. Using the final diagnosis as a gold standard, the sensitivity of 16S rRNA gene sequencing was fair. In the setting with no 16S...

This cohort study characterizes inappropriate diagnosis of community-acquired pneumonia among hospitalized patients in 48 Michigan hospitals.

Purpose of Review Broadly neutralizing antibodies (bNAbs) represent a novel approach to HIV treatment, prevention, and cure strategies. As research advances, the clinical application of bNAbs continue...

BackgroundDiabetic foot osteomyelitis (DFO) is a severe complication of diabetic foot infections (DFI). Early and accurate diagnosis is crucial for improving...

In April 2024—over 40 years after its first approval in Europe—pivmecillinam received approval from the United States Food and Drug Administration (FDA) for the treatment of uncomplicated urinary trac...

Inactivation of β-lactams by the action of β-lactamase enzymes is the most common mode of resistance to these drugs among Gram-negative organisms. The genomes of some key clinical pathogens such as En...