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Mark Howarth Lab

@howarthsci.bsky.social
124 followers 73 following 26 posts

Mark Howarth research group at University of Cambridge Department of Pharmacology: Innovating Protein Technologies for Therapeutics and Vaccine Design. www.howarthgroup.org

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Mark Howarth Lab @howarthsci.bsky.social · 22/09/2026
Was reading in my local newspaper, Universe Today, that SpyTag may be used to help make building materials for Mars: www.universetoday.com/articles/gen...
universetoday.com
Genetically Engineered Yeast Could Build the First Martian Outposts
If we are ever to have a permanent presence on Mars, we will have to learn to build there. Shipping the material from Earth to build something as simple as a pressurized habitat is prohibitively expen...
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Mark Howarth Lab @howarthsci.bsky.social · 02/09/2026
Proteins must wiggle for the body to function. Excited to have our pre-print out on watching such wiggling, through great collaboration with Eamonn Reading (not shown below) www.biorxiv.org/content/10.6...
static.klipy.com
José Mourinho's Energetic Dance Wiggle
ALT: José Mourinho's Energetic Dance Wiggle
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Mark Howarth Lab @howarthsci.bsky.social · 02/09/2026
Pleased to get your comments on our pre-print: a new route to antibody clicking, led by David Spring's lab: chemrxiv.org/doi/full/10....
chemrxiv.org
Divinyl-s-tetrazine as a Minimal Linchpin for Peptide Stapling, Protein Disulfide Re-bridging and Click Functionalisation | ChemRxiv
Site-selective bridging of cysteines and native disulfide bonds represents a powerful strategy for peptide and protein modification. However, most existing bis-electrophilic reagents rely on azide-alk...
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Mark Howarth Lab @howarthsci.bsky.social · 01/05/2026
Look out for #PintOfScience this year and our lab is presenting in Castle Bar, Cambridge. #Pint26 pintofscience.co.uk/event/milk-m...
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Mark Howarth Lab @howarthsci.bsky.social · 01/05/2026
Our pre-print is out on building a vaccine against Herpes Simplex Virus, a great collaboration with Jeff Cohen's lab through NIH OxCam and keen to get your comments: www.biorxiv.org/content/10.6... #vaccines
biorxiv.org
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Mark Howarth Lab @howarthsci.bsky.social · 02/04/2026
Well done to the group for educating another lot of youngsters what are #vaccines and how to build them with sticky proteins at the Cambridge Festival 2026! 955 people through the door @campathology.bsky.social @cambridgefestival.bsky.social
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Mark Howarth Lab @howarthsci.bsky.social · 02/04/2026
Will be speaking online at this free Protein Engineering festival- check out lots of cool #synbio talks: www.eusynbios.org/eusynbioscal... @eusynbios.org @phar.cam.ac.uk
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Mark Howarth Lab @howarthsci.bsky.social · 02/04/2026
Pleased to report on our RSC vaccine symposium this week: www.linkedin.com/pulse/what-w... @rsc.org #vaccines #synbio @engbioirc.bsky.social
linkedin.com
“What works for cats works for proteins, exactly the same way” and other learnings from the RSC Vaccine symposium
It was great to host the Royal Society of Chemistry symposium this Monday, on “Integrating chemistry, engineering and biology to create the next generation of vaccines”. The title quote is from Neil K...
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Mark Howarth Lab @howarthsci.bsky.social · 06/02/2026
Our perspective with Oliver Bannard on DNA origami for vaccination is out: www.science.org/doi/10.1126/...
science.org
A double helix twist in HIV vaccine design
DNA origami scaffolds displaying HIV antigens stimulate focused antibody responses in mice
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Mark Howarth Lab @howarthsci.bsky.social · 06/02/2026
Our alum Douglas Adams: "I love deadlines. I like the whooshing sound they make as they fly by". Well, we had a deadline and after whooshing/gnashing, now we’ve another for you- 23 Feb. Many exciting submissions so far to "Integrating chem/eng/biol for next gen of vaccines" and still time for more
media.tenor.com
a poster that says do n't panic in red letters
ALT: a poster that says do n't panic in red letters
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Mark Howarth Lab @howarthsci.bsky.social · 14/01/2026
Two weeks left to register and submit abstracts for our symposium in Cambridge "Integrating chemistry, engineering and biology to create the next generation of vaccines" @rscchembio.rsc.org @rsc-ppsg.bsky.social @cambridgephysics.bsky.social @eng.cam.ac.uk @rscbiomaterchem.bsky.social #vaccines
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Mark Howarth Lab @howarthsci.bsky.social · 07/11/2025
Preprint released on enveloped virus-like particles and antigen quartets, from collaboration of Rory in our group with labs of Magnus Hoffmann and Pamela Bjorkman- keen to get comments www.biorxiv.org/content/10.1... #vaccines #synbio
biorxiv.org
mRNA delivery of genetically encoded mosaic-8 pan-sarbecovirus RBD vaccines
Global health remains threatened by spillovers of zoonotic SARS-like betacoronaviruses (sarbecoviruses) that could be mitigated by a pan-sarbecovirus vaccine[1][1]. We described elicitation of potentl...
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Mark Howarth Lab @howarthsci.bsky.social · 07/11/2025
Pleased to work with Addgene on this blog post relating to their fantastic resources. #synbio
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Mark Howarth Lab @howarthsci.bsky.social · 07/11/2025
Delighted to invite you to the RSC symposium, “Integrating chemistry, engineering and biology to create the next generation of vaccines” at Queens’ College Cambridge on 30th March 2026. www.rsc.org/events/detai... @rsc.org #vaccines #immunology #synbio #biophysics
rsc.org
Integrating chemistry, engineering and biology to create the next generation of vaccines
Engineering Biology Interdisciplinary Research Centre
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Mark Howarth Lab @howarthsci.bsky.social · 19/06/2025
How to make a NanoBondy- looking forward to your feedback on Lasya's preprint: www.biorxiv.org/content/10.1...
biorxiv.org
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Mark Howarth Lab @howarthsci.bsky.social · 19/06/2025
My perspective is online from today on the power of a few good reactions: What is Click Biology? What can it do for you? What can you do for Click Biology? Keen to discuss. rdcu.be/erMjs #synbio @rsc.org #chemistry
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Mark Howarth Lab @howarthsci.bsky.social · 06/06/2025
Here is our paper on generating a Monkeypox vaccine candidate www.nature.com/articles/s41... led by Bernie Moss lab. Plug-and-display VLPs give a high level of protection, beating the standard Vaccinia-based vaccine. #mpox #vaccines #synbio
media.tenor.com
a cartoon drawing of a virus with a face on a yellow background
ALT: a cartoon drawing of a virus with a face on a yellow background
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Mark Howarth Lab @howarthsci.bsky.social · 19/05/2025
Buy yourself an antibody➡️Clever chemistry from the Spring lab (tetraDVP) 🪄SpyTag is coupled at the hinge and then the fun can begin... Great collaboration along with @claudiadriscoll.bsky.social‬ pubs.rsc.org/en/content/a... #synbio #antibody #biotech
pubs.rsc.org
A platform for SpyCatcher conjugation to native antibodies
Protein–antibody conjugates represent major advancements in targeted therapeutics. However, platforms enabling ‘off-the-shelf’ antibody conjugation are seldom reported. The SpyTag/SpyCatcher system, k...
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Mark Howarth Lab @howarthsci.bsky.social · 16/04/2025
Looking forward to speaking at Edinburgh Centre for Engineering Biology tomorrow, 9:30am in Waddington Building biology.ed.ac.uk/centre-engin...
biology.ed.ac.uk
Centre Seminar Series
Invited external speakers 2025
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Reposted by Mark Howarth Lab
British Society for Immunology @britsocimm.bsky.social · 30/01/2025
📢 Abstract submission for BSI Oxford and @immunologyoxford.bsky.social 's #OIS25 Symposium closes NEXT WEEK (7 Feb) Don't miss your chance to take part in this celebration of the outstanding #immunology research happening across Oxford 💫 Submit your abstract here 👉 bit.ly/4elJmnG
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Mark Howarth Lab @howarthsci.bsky.social · 06/02/2025
How to find the best partners and strike a pose at the cell membrane? See lab's recent review with @claudiadriscoll.bsky.social www.sciencedirect.com/science/arti... #synbio #antibody #biotech
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Reposted by Mark Howarth Lab
Engineering Biology Interdisciplinary Research Centre @engbioirc.bsky.social · 27/11/2024
Followed by Lasya Vankayala and Ginevra Camboni showing work using the Neisslock system to improve CAR-T therapies for solid tumours, and a high-throughput platform for engineering enzyme replacement therapies.
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