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Hizu Khan

@hizukhan.bsky.social

7 followers 79 following 4 posts

Microbial Genomics | Epidemiology | AMR | Passionate about advancing genomics and clinical data analysis through collaboration. Opinions are my own!

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Hizu Khan @hizukhan.bsky.social · 10/05/2026

New MTB genomics study: screening 2,506 Vietnamese isolates + MTBC reveals repeated positive selection and reductive evolution in the dormancy regulon, especially Rv0080. Mutations may boost hypoxia survival, suggesting adaptation to human hosts | Nature Communications. #Tuberculosis #Genomics

Dormancy regulon reduction was pivotal to the evolution of Mycobacterium tuberculosis - Nature Communications

Mycobacterium tuberculosis owes its success partly to its ability to enter a ‘dormant’, non-replicative state, reactivating years or even decades after initial infection. In this work, authors find th...

Hizu Khan @hizukhan.bsky.social · 08/05/2026

15,000 A. baumannii genomes reveal an epidemic super-lineage behind ~70% of global isolates and a fast-spreading East Asian Clade 2.5.6, fueled by ARG/virulence gains. One Health action needed. #AMR #OneHealth www.nature.com/articles/s41...

Emergence and global spread of a dominant multidrug-resistant clade within Acinetobacter baumannii - Nature Communications

In this study, authors conduct a genomic analysis of 15,000 Acinetobacter baumannii isolates, revealing a dominant multidrug-resistant super-lineage (accounting for approximately 70% global…

Hizu Khan @hizukhan.bsky.social · 08/05/2026

Non-human A. baumannii are more diverse than clinical isolates. Analysis of >23,000 genomes reveals higher ANI/ST diversity, a frequent human–animal/environment transmission. Dogs, horses, and wastewater harbor many ARGs, a One Health concern. #OneHealth #AMR #genomics doi.org/10.1038/s414...

Hizu Khan @hizukhan.bsky.social · 07/05/2026

DeepDTAGen integrates drug–target affinity prediction with target-aware drug generation, offering a multitask deep learning approach for AI-driven drug discovery. #DrugDiscovery #DeepLearning #AIinMedicine #Cheminformatics #Bioinformatics www.nature.com/articles/s4...

DeepDTAGen: a multitask deep learning framework for drug-target affinity prediction and target-aware drugs generation

Nature Communications - The authors proposed a multi-task deep learning model, to accurately predict drug-target affinity and generate target-aware drugs. In the proposed model, the authors...