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Hirabayashi Lab - UTokyo

@hirabayashi-lab.bsky.social
38 followers 22 following 9 posts
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Hirabayashi Lab - UTokyo @hirabayashi-lab.bsky.social · 09/01/2026
Our new study is published! We show that the mitochondria–ER tether PDZD8 undergoes liquid–liquid phase separation and acts not just as a bridge, but as a molecular glue that wets ER and mitochondrial membranes to expand contact sites. www.cell.com/molecular-ce...
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Hirabayashi Lab - UTokyo @hirabayashi-lab.bsky.social · 18/04/2025
After 6 years of careful experiments, we’re excited to share our latest manuscript on the identification and function of the PDZD8–FKBP8 protein complex! We now have convincing evidence that structural regulation of mitochondria via ER–mitochondria tethering proteins is real. rdcu.be/eihrF
rdcu.be
Mitochondrial complexity is regulated at ER-mitochondria contact sites via PDZD8-FKBP8 tethering
Nature Communications - How PDZD8 acted in Mitochondria-ER contact formation was unclear. Here, the authors show that binding to mitochondrial FKBP8 slows PDZD8’s rapid motion, enhancing...
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