Background Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with poor prognosis and limited curative treatment options. While chimeric antigen receptor (CAR) T cells have shown some ...

Rodriguez et al. demonstrate that VLA-4-targeted low-dose radiopharmaceutical therapy enhances CAR T cell activity and drives tumor regression in neuroblastoma mouse models. Mechanistically, RPT promotes tumor cell killing and TNF-α-mediated T cell activation in radio-sensitive tumors, while it remodels the myeloid compartment and fosters CAR T cell niches in radio-resistant tumors.

Rodriguez et al. demonstrate that VLA-4-targeted low-dose radiopharmaceutical therapy enhances CAR T cell activity and drives tumor regression in neuroblastoma mouse models. Mechanistically, RPT promo...

Phadke and colleagues developed a radiotheranostic platform with 89Zr-mCT3 for non-invasive GPC2 imaging via immunoPET and 225Ac-mCT3 for targeted alpha-particle therapy. 89Zr-mCT3 served as a novel r...