NEW PUBLICATION
How can variations in a single gene be associated to conditions as distinct as obesity, depression, schizophrenia and autism? A gene called Negr1 exemplifies pleiotropy.
We have just published work trying a new way to address this problem.
www.biorxiv.org/content/10.6...
biorxiv.org
Cellular and molecular census of the pleiotropic disease locus Negr1 in zebrafish
A major challenge in precision medicine is to understand the cellular origin of disease-causing genetic alterations. One prominent example is the Negr1 locus, where common non-coding variants are asso...