Herbert Wu @herbertwu.bsky.social · 26/08/2026it was a pleasure. Thank you for playing an important part of it Evan! 010
Herbert Wu @herbertwu.bsky.social · 20/08/2026A true cooperative effort led by the talented Yuan Cheng and Yusi Chen, with amazing collaborators @nan-mssm.bsky.social, @nuttidanuttida.bsky.social, @esschaffer.bsky.social, Matt Whiteway, @talmo.bsky.social, Myungji Kwak and others. (3/3) 030
Herbert Wu @herbertwu.bsky.social · 20/08/2026These findings reveal how leader–follower dynamics are instantiated as asymmetric prefrontal representations, linking role-based decision-making to egocentric partner encoding at the cellular resolution. (2/3) 232
Herbert Wu @herbertwu.bsky.social · 20/08/2026First study out! Using a new cooperative paradigm and multi-agent inverse RL, we show that mice spontaneously adopt leader/follower roles, and the prefrontal cortex encodes these role dynamics and an egocentric social value map of the partner’s position. (1/3) www.nature.com/articles/s41...nature.comAsymmetric prefrontal representations for leader–follower dynamics - NatureMice spontaneously form leader and follower roles during cooperation, and the medial prefrontal cortex encodes these role dynamics and an egocentric social value map of the partner’s position. 48124
Reposted by Herbert WuThe Friedman Brain Institute @sinaibrain.bsky.social · 19/08/2026NEW STUDY! @mountsinainyc.bsky.social's Yuan Cheng, @herbertwu.bsky.social, et al. provide the first mouse model of leader-follower teamwork & link it to specific patterns of prefrontal cortex activity at the level of single cells. Learn More | Full Text @nature.com ➡️ www.nature.com/articles/s41... 0113
Herbert Wu @herbertwu.bsky.social · 09/06/2026Thank you to the McKnight Foundation for this incredible honor. I'm deeply grateful to my lab, mentors and colleagues, and especially thankful for the unwavering support of Mount Sinai community. This reflects a true team effort, and I'm excited for the work ahead!🧠🙏 1181
Herbert Wu @herbertwu.bsky.social · 12/09/2025Thanks so much for the generous support from @sinaibrain.bsky.social and the Glickenhaus Family! 031
Herbert Wu @herbertwu.bsky.social · 05/09/2025Thanks so much! Naive animals are untrained animals that don’t know how to cooperate 010
Herbert Wu @herbertwu.bsky.social · 04/09/2025This was a truly collaborative effort and will open new avenues to probe social cognition and collective behavior. Huge thanks to the amazing team who made this cooperation😁 possible! @esschaffer.bsky.social @nuttidanuttida.bsky.social @talmo.bsky.social @nan-mssm.bsky.social (5/5) 170
Herbert Wu @herbertwu.bsky.social · 04/09/2025To uncover latent strategies, we built a multi-agent inverse RL (MAIRL) model with joint value decomposition. MAIRL infers individual goal and interaction maps that mirror asymmetric neural codes and are decodable from mPFC population activity, linking behavior, circuit, and computation (4/5) 120
Herbert Wu @herbertwu.bsky.social · 04/09/2025The medial prefrontal cortex (mPFC) represents both trial-by-trial leadership dynamics and enduring social roles. It also encodes a role-based, egocentric “social value map” of partner's position that adapts to task demand. Disrupting mPFC impairs cooperation and shifts self–partner weighting (3/5) 130
Herbert Wu @herbertwu.bsky.social · 04/09/2025Both leaders and followers integrate partner position into their decision-making, exerting asymmetric yet reciprocal influence. Forward multi-agent RL (MARL) shows simulated agents can learn the task and also develop stable leader–follower dynamics, suggesting social roles can self-organize (2/5) 121
Herbert Wu @herbertwu.bsky.social · 04/09/2025Super excited to share the first cooperative foraging paradigm in freely interacting mouse pairs! Stable leader and follower roles emerge spontaneously and predict learning. Well-trained mice show stereotyped, role-specific “behavioral motifs” absent in naive animals (1/5) doi.org/10.1101/2025... 67225
Herbert Wu @herbertwu.bsky.social · 29/08/2025Fascinating! The use of social gaze seems quite complicated in these cooperating marmosets 030
Reposted by Herbert WuCatherine Dulac @dulaclab.bsky.social · 11/08/2025Very excited to announce our latest paper uncovering circuit, cellular and molecular mechanisms underlying the formation and maintenance of social hierarchy, another terrific collaboration with @neurovenki.bsky.social, Vic Kapoor and Adam Nelson (not on bsky) www.sciencedirect.com/science/arti...sciencedirect.comMolecular and neural control of social hierarchy by a forebrain-thalamocortical circuitMany animal groups are organized hierarchically, which generates behavioral states that facilitate social interactions. Although generally stable, soc… 18019
