Reposted by Henry Bell
A mouse study in Nature demonstrates durable repression of a gene that has a role in controlling cholesterol levels, achieved without permanent genome editing. 🧪
go.nature.com
Durable and efficient gene silencing in vivo by hit-and-run epigenome editing - Nature
Experiments in mice show that designed epigenome editors that contain domains of transcriptional repressors can enable stable epigenetic silencing of Pcsk9, a gene with a role in cholesterol homeostas...
