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Hematology Advisor

@hematologyadvisor.bsky.social
173 followers 142 following 430 posts

HematologyAdvisor.com is a trusted knowledge base of practical information and resources focused on hematology and critical care medicine.

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Hematology Advisor @hematologyadvisor.bsky.social · 02/10/2026
POP QUIZ💥 When should a patient with transfusion-dependent #Thalassemia be started on iron chelation therapy? See if you can pass our most recent clinical quiz here: bit.ly/4AMMohb
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Clinical Quiz: Iron Overload in Thalassemia - Hematology Advisor
Take this quiz to test your knowledge on the monitoring and management of iron overload in patients with thalassemia.
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Hematology Advisor @hematologyadvisor.bsky.social · 01/10/2026
Fixed-duration linvoseltamab therapy yielded a 100% ORR & prevented progression to active disease, with a manageable safety profile, in patients with high-risk smoldering #MultipleMyeloma! From the updated phase 2 LINKER-SMM1 study presented at #IMS26 🔗 Read more: bit.ly/4hnw8M7
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IMS 2026: Linvoseltamab May Yield Durable Responses in High-Risk Smoldering MM
Phase 2 safety and efficacy data showed fixed-duration linvoseltamab prevented disease progression and produced deep responses in pts w/ high-risk smoldering multiple myeloma.
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Hematology Advisor @hematologyadvisor.bsky.social · 25/09/2026
It's #BloodCancerAwarenessMonth!🩸 We recently interviewed experts C. Ola Landgren, MD, PhD and Kenneth Shain, MD, PhD to discuss the evolving treatment landscape and risk stratification methods for patients with high-risk smoldering #MultipleMyeloma Read the full interview: bit.ly/47iDKcC
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Hematology Advisor @hematologyadvisor.bsky.social · 22/09/2026
A study in Hematology Reports highlights a growing divide in global #Hemophilia care: while advanced therapies transform outcomes, many patients globally still lack basic access to care and diagnosis. Read more: bit.ly/4yQ60zk
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Global Disparities in Hemophilia Care
There are persistent global disparities in access to care for patients with hemophilia, coupled with problems in healthcare infrastructure and research capacity.
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Hematology Advisor @hematologyadvisor.bsky.social · 21/09/2026
A phase 2 study presented at #SOHO2026 evaluated frontline low-dose nivolumab (40 mg) + AVD for #HodgkinLymphoma: 🔹 95.8% ORR after 2 cycles 🔹 86.7% ORR after 6 cycles 🔹 75% total drug cost reduction vs standard dose 🩸Read more: bit.ly/4yjkaZC
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Hematology Advisor @hematologyadvisor.bsky.social · 15/09/2026
It's #WorldLymphomaAwarenessDay! 💚 💜 Non-Hodgkin Lymphoma is one of the most common cancers in America, accounting for about 4% of cancer cases. (@americancancersoc.bsky.social) Thank you to the clinicians and researchers working towards improving the quality of life for patients with #Lymphoma!
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Hematology Advisor @hematologyadvisor.bsky.social · 12/09/2026
The phase 3 TERZO trial presented at #SOHO2026 investigating whether duvelisib monotherapy can improve progression-free survival over standard chemotherapy in adults with relapsed or refractory nodal T cell-follicular helper lymphoma. See more: bit.ly/4yEVquZ
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Hematology Advisor @hematologyadvisor.bsky.social · 11/09/2026
New research presented at the @societyofhemonc.bsky.social 2026 Annual Meeting showed promising results for a specific group of patients with AL amyloidosis. #SOHO2026 Read the full article here: bit.ly/4ikR2fF
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Hematology Advisor @hematologyadvisor.bsky.social · 11/09/2026
More from #SOHO2026! Frontline 2nd-generation TKIs (dasatinib/nilotinib) show significantly more durable disease control than imatinib in Ph+ ALL High baseline disease burden (hemoglobin < 8 g/dL, LDH ≥ 691 U/L, higher BCR::ABL1) independently predicted worse outcomes. More: bit.ly/46kVhAB
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Hematology Advisor @hematologyadvisor.bsky.social · 11/09/2026
New from#SOHO2026, follow-up results from the phase 3 DREAMM-7 trial: BVd triplet demonstrated an OS benefit vs. the DVd triplet in relapsed/refractory #MultipleMyeloma across both ITT and 3+ prior line subgroups over 4+ years of follow-up. See more details here: bit.ly/4r9nUKH
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Hematology Advisor @hematologyadvisor.bsky.social · 11/09/2026
🚨 New research from #SOHO2026 highlights long-term immune dysfunction in survivors of childhood hematologic malignancies (mostly B-ALL), years after completing therapy. Source: @societyofhemonc.bsky.social #SOHO26 More here: bit.ly/4dv14r4
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Hematology Advisor @hematologyadvisor.bsky.social · 10/09/2026
Updated SUNMO trial data presented at #SOHO2026 shows Mosun-Pola outperforms standard of care (R-GemOx) in transplant-ineligible R/R LBCL! 🔬 🔹Median PFS: 11.6 vs 3.8 months (HR: 0.41) 🔹ORR: 70.3% vs 40.0% 🔹CR: 51.4% vs 24.3% Link to the story: bit.ly/3SXmBBW #SOHO26
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Hematology Advisor @hematologyadvisor.bsky.social · 10/09/2026
📈 2-year data from the Phase 3 SURPASS-ET trial presented at #SOHO2026 shows continuous ropeginterferon alfa-2b (ropeg) delivers durable hematologic & molecular benefits for high-risk essential thrombocythemia! More details: bit.ly/3TodPwU #SOHO26 #Thrombocythemia
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Hematology Advisor @hematologyadvisor.bsky.social · 10/09/2026
Encouraging real-world evidence presented by researchers at @mayoclinic.org during the @societyofhemonc.bsky.social Annual Meeting! 🩸 #SOHO2026 Late-line use of asciminib demonstrated considerable effectiveness in treating Ph+ALL! Read more here: bit.ly/4r7DdDx
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Hematology Advisor @hematologyadvisor.bsky.social · 10/09/2026
Research from #SOHO2026: The Phase 3 ECHO trial support frontline acalabrutinib + bendamustine–rituximab (ABR) for untreated mantle cell #Lymphoma! Key takeaways: • ~6 yrs vs. ~4 yrs median PFS favoring ABR over PBR • 32% lower risk of progression or death #SOHO26 🩸 More: bit.ly/4iiVXO8
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Hematology Advisor @hematologyadvisor.bsky.social · 10/09/2026
#SOHO2026: The addition of ianalumab to eltrombopag therapy provides patients with primary ITP with durable improvements in symptom burden and fatigue that persist even after eltrombopag discontinuation📊🩺 Source: The phase 3 VAYHIT2 trial #SOHO26 Link to article: bit.ly/4inSRbO
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Hematology Advisor @hematologyadvisor.bsky.social · 10/09/2026
New from #SOHO26! CALGB 10403 (C10403) protocol used in adolescents and young adults with acute lymphoblastic leukemia may be equally safe and effective in adults aged 40+! Read the full article here: bit.ly/4yx5upH #ALL #SOHO2026 #Leukemia
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Hematology Advisor @hematologyadvisor.bsky.social · 10/09/2026
New data presented at #SOHO2026 shows promising results for pirtobrutinib in treatment-naïve CLL/SLL! 🔬 📊 93.3% ORR 📈 93.2% 24-month PFS ❤️ 97.5% 24-month OS Low rate of discontinuation due to treatment-related adverse events (1.6%). @societyofhemonc.bsky.social Article: bit.ly/4j0oUyu
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Hematology Advisor @hematologyadvisor.bsky.social · 10/09/2026
A study in @jco-asco.bsky.social shows ALL patients in India aged 40+ face poor outcomes: 3-year OS was just 31%, driven by high infection mortality (18.6%) and treatment intolerance. Early access to targeted therapies and better support systems are critical. 🔬 Full Article: bit.ly/4hgDH6V
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Hematology Advisor @hematologyadvisor.bsky.social · 09/09/2026
The phase 3 DAYBreak CLL-306 study presented at #SOHO2026 shows researchers are investigating the efficacy and safety of bexobrutideg compared with the BTKi pirtobrutinib in patients with CLL/SLL who are relapsed or refractory to prior covalent BTKi treatment. Full article: bit.ly/4A2ECPR
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Hematology Advisor @hematologyadvisor.bsky.social · 09/09/2026
#SOHO2026 Starts TODAY!!🩸 We'll be covering this year's conference live on our website and our social platforms. Click the link below to be brought directly to our conference landing page. Are there any presentations you're looking forward to at #SOHO26? 🔗 bit.ly/4iT6fEO
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Hematology Advisor @hematologyadvisor.bsky.social · 08/09/2026
#SOHO2026 is all about driving research forward through collaboration! 🤝 Ahead of the meeting, we spoke with SOHO Vice Chair for leukemia and MDS, Rami S. Komrokji, MD about the top abstracts on his radar. Check out Dr. Komrokji's top picks: bit.ly/4xLprcr
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Hematology Advisor @hematologyadvisor.bsky.social · 07/09/2026
Pop Quiz! 📝 Check out the quiz below to test your knowledge on the NCCN Guidelines® on allo-HCT. 🔗 Link to quiz: bit.ly/4A1qOoH
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Clinical Quiz: NCCN Guidelines® on Allo-HCT - Hematology Advisor
Take this quiz to test your knowledge on the NCCN Guidelines® on allo-HCT.
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Hematology Advisor @hematologyadvisor.bsky.social · 05/09/2026
5-year ELIANA trial data in @jco-asco.bsky.social supports tisagenlecleucel as definitive therapy for pediatric/young adult r/r B-ALL: 🔹 88.6% best overall response rate 🔹 5-year estimated overall survival was 62.4% 🔹 5-year relapse-free survival reached 53.2% Read the full article: bit.ly/4id4Zw2
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Hematology Advisor @hematologyadvisor.bsky.social · 03/09/2026
It's #ChildhoodCancerAwarenessMonth! Phase 3 AAML1831 study: CPX-351 induction resulted in inferior event-free survival (51.2% vs. 62.2%) & higher relapse risk (44.3% vs. 31.7%) compared to standard DA in pediatric/young adult AML🩺 Read the full article: bit.ly/3UujOAB
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Hematology Advisor @hematologyadvisor.bsky.social · 01/09/2026
September is #BloodCancerAwarenessMonth! 🩸🎗️ Thank you to all the clinicians and researchers who are working tirelessly to help patients with #Leukemia, #Lymphoma, #Myeloma, or other blood cancers live longer, healthier lives!
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Hematology Advisor @hematologyadvisor.bsky.social · 31/08/2026
Long-term phase 3 explorer8 results in @bloodadvances.bsky.social show daily subcutaneous concizumab prophylaxis is superior to on-demand care for #Hemophilia A or B without inhibitors. It maintained low bleeding rates and resolved 86.3% of target joints by 56 weeks. 🩸📉 🔗 bit.ly/4qLbFUv
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Hematology Advisor @hematologyadvisor.bsky.social · 28/08/2026
Adding blinatumomab to consolidation/maintenance therapy significantly improves outcomes for adults with high-risk Ph-negative B-ALL (phase 2 GRAALL-2014/B-QUEST study): Read the full article here: bit.ly/3SmJMFu
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Blinatumomab Improves Survival in High-Risk Ph-Negative B-ALL
Blinatumomab added to consolidation and maintenance therapy improves survival in adults with high-risk Ph-negative B-ALL.
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Hematology Advisor @hematologyadvisor.bsky.social · 28/08/2026
Adding blinatumomab to consolidation & maintenance for high-risk Ph-negative B-ALL significantly improves survival in adults 🩺. Phase 2 GRAALL-2014/B-QUEST trial data show 5-year OS reached 79% (vs 60% with chemo alone) & lower relapse rates (23% vs 49%)! Read more here: bit.ly/3SmJMFu
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Hematology Advisor @hematologyadvisor.bsky.social · 26/08/2026
Blood Cancer Journal's study found adding venetoclax to HMA in frontline HR-MDS improved cCR🩺🧬 Primary OS was similar across the full cohort, but HMA/VEN showed significant OS benefit in key subgroups: 🔹 TP53 wild-type (HR 0.47, P<.001) 🔹 Post-allo-HCT OS (HR 0.49, P=.01) 🔗 bit.ly/4xEFuYY
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Hematology Advisor @hematologyadvisor.bsky.social · 25/08/2026
Promising news for pediatric #AML care published in @bloodjournal.bsky.social! 🩺 Pediatric patients achieved comparable remission & survival rates with a low-dose chemo induction regimen with significantly lower toxicity! 🧬 Read more about the study here: bit.ly/46aYH8N
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Hematology Advisor @hematologyadvisor.bsky.social · 24/08/2026
A new study from Blood Cancer Journal analyzing 1,900+ HR-MDS patients found adding venetoclax (VEN) to HMA therapy boosted composite complete remission rates (48.8% vs 27.7%) 🩸 Read here: bit.ly/4xEFuYY
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Frontline Hypomethylating Agent Therapy With Venetoclax Associated With Improved Remission in HR-MDS
Adding venetoclax to frontline hypomethylating agents may improve remission rates in patients with higher-risk myelodysplastic syndromes.
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Hematology Advisor @hematologyadvisor.bsky.social · 21/08/2026
Ph2 GRAALL-2014/B-QUEST: Adding blinatumomab to consolidation/maintenance improves 5-yr outcomes in high-risk Ph- adult B-ALL! 🩸 📈 5-Yr Data: • DFS: 68% vs 42% (HR 0.47) • OS: 79% vs 60% (HR 0.50) • Relapse: 23% vs 49% Undetectable MRD hit 72% vs 55% post-consolidation. 🔗 bit.ly/3SmJMFu
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Hematology Advisor @hematologyadvisor.bsky.social · 20/08/2026
Retrospective registry analysis in Blood Cancer Journal: Adding venetoclax (VEN) to HMAs in frontline higher-risk MDS (HR-MDS) shows significant cCR gains & subgroup OS benefits! 🩸🩺 Highlights potential subgroup-specific benefits for combination strategy. See the data here: bit.ly/4xEFuYY
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Hematology Advisor @hematologyadvisor.bsky.social · 18/08/2026
Ph3 trial data in Blood: Low-dose chemotherapy induction is non-inferior to standard dosing in pediatric AML with significantly lower toxicity! 🩸🩺 📊 Efficacy: • CR/CRi: 95.1% (LDC) vs 95.3% (Standard) • 4-yr EFS: 61.5% vs 63.1% (P=.832) • 4-yr OS: 81.3% vs 83.6% (P=.611) bit.ly/46aYH8N
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Hematology Advisor @hematologyadvisor.bsky.social · 17/08/2026
New research evaluates novel biomarker models (HAG & HAG-C) for predicting aGVHD in ATG-based haplo-HSCT: Biomarkers: Plasma ST2, REG3α, Elafin🩸 Accuracy: Performance comparable to MAGIC (weighted avg AUC ~0.68) Read all the data here: bit.ly/4bV5cA6
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Hematology Advisor @hematologyadvisor.bsky.social · 17/08/2026
#ICYMI Last week, the FDA approved iberdomide with daratumumab and hyaluronidase-fihj and dexamethasone for adults with #MultipleMyeloma For more information on all of the hematology FDA approvals from the first half of 2026, see our FDA roundup with the link below! 🔽 bit.ly/457XMG1
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Hematology Advisor @hematologyadvisor.bsky.social · 14/08/2026
Pop Quiz! Take this quiz to test your knowledge on the ISTH SSC working group’s guidelines on gene therapy for patients with hemophilia. bit.ly/4gen0HC
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Clinical Quiz: ISTH SSC Guidelines on Gene Therapy for Hemophilia - Hematology Advisor
Take this quiz to test your knowledge on the ISTH SSC working group’s guidelines on gene therapy for patients with hemophilia.
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Hematology Advisor @hematologyadvisor.bsky.social · 13/08/2026
Can a gene marker predict transplant success in #MultipleMyeloma? 🧬 A study in Biochemical Genetics shows high pretransplant SGK1 expression significantly raises disease progression risk (HR 3.439) and cuts survival time. Read more here: bit.ly/4qaFcqa
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Hematology Advisor @hematologyadvisor.bsky.social · 10/08/2026
ICYMI! A phase 2 study published in @thelancethaem.bsky.social found besponsa met it's primary endpoint for children with pediatric B-ALL. Read the research here🔽 bit.ly/4zaKExt
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Hematology Advisor @hematologyadvisor.bsky.social · 07/08/2026
Results from a large observational study from @BrJHaem found patients with CLL with Richter transformation who were treatment exposed demonstrated the shortest TTNTd and OS.📉 This study highlights the need for novel therapies to treat #ChronicLymphocyticLeukemia. Read the data here🔽 bit.ly/4fZXupA
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Hematology Advisor @hematologyadvisor.bsky.social · 05/08/2026
News from Orphanet: Mortality rates for #SickleCellDisease have tripled in Colombia since 2012 with the highest burden in socioeconomically disadvantaged regions. 🇨🇴 The annual #SCD related deaths increased from 25 in 2012 to 74 in 2023. For more data: bit.ly/4wZH87P
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Hematology Advisor @hematologyadvisor.bsky.social · 04/08/2026
5-year update from the phase 3 CLL13/GAIA trial in Blood! 🩸 Fixed-duration triplet therapy (venetoclax + obinutuzumab + ibrutinib/GIV) showed the highest PFS in treatment-naïve CLL: 📊 5-Year PFS Rates: • GIV: 81.3% • GV: 69.8% • RV: 57.4% • CIT: 50.7% 🔗 bit.ly/4xk3Ner
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Triplet Therapy Demonstrates Long-Term PFS Benefit in CLL
A 5-year analysis of the GAIA/CLL13 trial evaluates fixed-duration venetoclax combinations for previously untreated CLL.
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Hematology Advisor @hematologyadvisor.bsky.social · 03/08/2026
Patients with Medicare Advantage coverage may be less likely to receive combination therapies against #MultipleMyeloma compared with those with traditional Medicare coverage. Study originally published in JCO Oncology Practice, read our coverage here: bit.ly/4pW3iF6
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Hematology Advisor @hematologyadvisor.bsky.social · 30/07/2026
NEW! FDA Roundup H1 2026: Hematology Drug Alerts See some significant hematology and oncology FDA drug approval news from the first half of 2026, including Decnupaz, Hympavzi, and Opdivo. 🔗 bit.ly/457XMG1 #Hematology #HemOnc
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FDA Roundup H1 2026: Hematology Drug Alerts
See some significant FDA hematology drug alert news from the first half of 2026, including Decnupaz, Hympavzi, and Opdivo.
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Hematology Advisor @hematologyadvisor.bsky.social · 29/07/2026
A new study reveals that over 25% of surveyed European countries lack access to CD19 CAR T-cell therapy for pediatric B-ALL. 🧬 Researchers stress the urgent need for a coordinated regional framework to ensure equitable access to life-saving cellular therapies. 🩺 More data: bit.ly/4fj0Bd8
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Disparities Limit Equitable Access Across Europe to Pediatric CD19 CAR-T Therapy
Researchers identified gaps in clinical trials and referral systems that limit equitable access to CAR-T therapy for pediatric B-ALL in Europe.
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Hematology Advisor @hematologyadvisor.bsky.social · 27/07/2026
Interview Spotlight with Dr Hamza Hashmi on CAR-T therapy challenges in extramedullary #MultipleMyeloma! Dr Hashmi discusses the challenges, as well as ongoing needs and developments in extramedullary MM in the interview below. 🔗 bit.ly/4fEFpNL
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Hematology Advisor @hematologyadvisor.bsky.social · 27/07/2026
🆕 More from @bloodadvances.bsky.social Twice-daily deferiprone (DFP) appeared well-tolerated in a real-world study that included patients with thalassemia, #SickleCellDisease, or other anemias and transfusional iron overload. 🩸 See the data: bit.ly/4vOZOpm
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Twice-Daily Deferiprone Well Tolerated in Real-World Anemia Clinical Practice
Twice-daily deferiprone is well tolerated in patients with transfusional iron overload due to thalassemia, sickle cell disease, or other anemias.
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Hematology Advisor @hematologyadvisor.bsky.social · 26/07/2026
A phase 3 subgroup analysis in Blood Advances shows CPX-351 improved overall survival compared to 7+3 chemotherapy in older adults with myelodysplastic-related AML (median OS 9.7 vs 6.8 months). 🩺 Find all the data here: bit.ly/3TmQzPx
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Hematology Advisor @hematologyadvisor.bsky.social · 24/07/2026
More from @bloodjournal.bsky.social! Treatment with ravulizumab throughout pregnancy was associated with favorable maternal and fetal outcomes among women with paroxysmal nocturnal hemoglobinuria.🤰 🔗 bit.ly/4pEftGC
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