Reposted by Han Kim
I am happy to share the latest preprint from our lab (@ircm.bsky.social, @umontreal.ca, @mcgill.ca) exploring why and how the liver gets fatty when you are fasting, and how this could impact MASLD.
www.biorxiv.org/content/10.1...
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biorxiv.org
Glucagon-induced PGC-1α4/PPARγ promotes hepatic lipid storage and macrosteatosis in fasting and MASLD
The liver plays a central role in regulating the transition between fasting and feeding states, coordinating glycogen breakdown, gluconeogenesis, fatty acid catabolism, and lipid storage. Disruptions ...