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Brian Krueger, PhD

@h2so4hurts.bsky.social
9K followers 8.8K following 376 posts

Scientific strategist | Storyteller | Genomics, Lab diagnostic and high throughput automation | Coder | Comments are my own | Omic.ly

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Brian Krueger, PhD @h2so4hurts.bsky.social · 05/08/2025
@whysharksmatter.bsky.social Thoughts? www.youtube.com/watch?v=VdGb...
youtube.com
Shark Dentist - Official Announcement Trailer
YouTube video by IGN
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Brian Krueger, PhD @h2so4hurts.bsky.social · 15/07/2025
DNA is coded by 4 bases, but no one said that's how we have to sequence it. Ready to have your mind bent? 🧬 🧪
omic.ly
Fuzzy Sequencing: Sometimes close enough is good enough
DNA is coded by 4 bases, but no one said that's how we have to sequence it. Ready to have your mind bent?
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Brian Krueger, PhD @h2so4hurts.bsky.social · 20/05/2025
Having trouble sleeping? A new mutation has been discovered that allows people to feel well rested after as little as 4hrs of sleep! 🧬 🧪 www.omic.ly/a-gene-for-s...
omic.ly
A gene for short sleep duration
Having trouble sleeping? A new mutation has been discovered that allows people to feel well rested after as little as 4hrs of sleep!
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Brian Krueger, PhD @h2so4hurts.bsky.social · 17/05/2025
So you're cherry picking out all the parts of a post about Rosalind Franklin and her life that don't mention Rosalind Franklin and her life? Cool.
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Brian Krueger, PhD @h2so4hurts.bsky.social · 17/05/2025
Apparently you didn't read the link?
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Brian Krueger, PhD @h2so4hurts.bsky.social · 17/05/2025
The most famous photo in the history of genetics wasn’t generated by Watson and Crick, but that didn’t stop them from using it to solve the structure of DNA. 🧬 🧪 #histSci www.omic.ly/the-most-fam...
omic.ly
The most famous picture in the history of genetics
The most famous photo in the history of genetics wasn’t generated by Watson and Crick, but that didn’t stop them from using it to solve the structure of DNA.
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Brian Krueger, PhD @h2so4hurts.bsky.social · 15/05/2025
Mass Spec is leading the charge in bringing high-throughput proteomics to a lab near you. 🧬 🧪 www.omic.ly/mass-spec-is...
omic.ly
Mass spec is primed to lead the next proteomics revolution
Mass Spec is leading the charge in bringing high-throughput proteomics to a lab near you.
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Brian Krueger, PhD @h2so4hurts.bsky.social · 13/05/2025
There’s more to de novo mutations (DNMs) than just SNPs and indels. 🧬 🧪 www.omic.ly/de-novo-muta...
omic.ly
De novo mutations are more common than we previously thought
There’s more to de novo mutations (DNMs) than just SNPs and indels.
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Brian Krueger, PhD @h2so4hurts.bsky.social · 01/05/2025
Multiplex aptamer/antibody arrays are a gateway drug to get genetics people to embrace proteomics. 🧬 🧪 www.omic.ly/how-to-do-pr...
omic.ly
How to do proteomics using a high throughput sequencer
Multiplex aptamer/antibody arrays are a gateway drug to get genetics people to embrace proteomics.
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Brian Krueger, PhD @h2so4hurts.bsky.social · 29/04/2025
Approximately 2,000 people die every year waiting for a liver transplant. Pigs might help change that! 🧬 🧪 www.omic.ly/a-pig-liver-...
omic.ly
A pig liver makes its way into a human
Approximately 2,000 people die every year waiting for a liver transplant. Pigs might help change that!
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Brian Krueger, PhD @h2so4hurts.bsky.social · 24/04/2025
High throughput proteomics could revolutionize our understanding of human disease, but it's going to take some major innovations to get us there! 🧬 🧪 www.omic.ly/the-future-o...
omic.ly
The future of high throughput proteomics is unfolding right in front of us
High throughput proteomics could revolutionize our understanding of human disease, but it's going to take some major innovations to get us there!
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Brian Krueger, PhD @h2so4hurts.bsky.social · 22/04/2025
Ultima Genomics is put to the test in MRD 🧬 🧪 www.omic.ly/will-ultimas...
omic.ly
Will Ultima's ultra cheap bases be a major boon to MRD?
Ultima Genomics is put to the test in MRD
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Brian Krueger, PhD @h2so4hurts.bsky.social · 21/04/2025
Derek Lowe telling it like it is: No, AI isn't going to cure all disease www.science.org/content/blog...
science.org
The End of Disease
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Brian Krueger, PhD @h2so4hurts.bsky.social · 18/04/2025
In 1994, an obscure jellyfish protein was stuck into a worm. It has enlightened biology and medicine ever since. 🧬 🧪 #HistSci www.omic.ly/jelly-fish-p...
omic.ly
Jelly fish proteins started brightening up microscopy in 1994
In 1994, an obscure jellyfish protein was stuck into a worm. It has enlightened biology and medicine ever since.
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Brian Krueger, PhD @h2so4hurts.bsky.social · 18/04/2025
this link got truncated and doesn't go to the post 😭
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Brian Krueger, PhD @h2so4hurts.bsky.social · 18/04/2025
HAHA, as long as you pronounce it econ-Omics I'll allow it...
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Brian Krueger, PhD @h2so4hurts.bsky.social · 18/04/2025
I made a feed for all things Omics! Have your posts included in it by adding a 🧬plus any additional omics related emoji🧪🧫🔬🖥️💉🦠🥼. Anything Genomics, Epigenomics, Transcriptomics, Proteomics, Metabolomics, or Metagenomics related (or adjacent!) is welcome! bsky.app/profile/h2so...
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Brian Krueger, PhD @h2so4hurts.bsky.social · 17/04/2025
The importance of taking out the trash: An overview of cellular protein degradation pathways. 🧬 🧪 www.omic.ly/the-proteaso...
omic.ly
The proteasome and lysosome decide what proteins live or die
The importance of taking out the trash: An overview of cellular protein degradation pathways.
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Brian Krueger, PhD @h2so4hurts.bsky.social · 16/04/2025
HOT TAKE: Dire wolves are still very much extinct, Illumina is dumping its smallest sequencer, and PacBio finally sees the light www.omic.ly/de-extincted...
omic.ly
De-extincted" Dire Wolves, A Discontinued Sequencer, and PacBio Goes Long
HOT TAKE: Dire wolves are still very much extinct, Illumina is dumping its smallest sequencer, and PacBio finally sees the light
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Brian Krueger, PhD @h2so4hurts.bsky.social · 15/04/2025
Deep brain structures play a key role in filtering out what we perceive 🧬 🧪 www.omic.ly/how-does-the...
omic.ly
How does the brain control perception of everything around us?
Deep brain structures play a key role in filtering out what we perceive
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Brian Krueger, PhD @h2so4hurts.bsky.social · 14/04/2025
Definitely a miracle of modern science.
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Brian Krueger, PhD @h2so4hurts.bsky.social · 14/04/2025
Interesting especially considering they have this thing with Biomerieux: www.biomerieux.com/us/en/journa...
biomerieux.com
bioMérieux makes strategic investment in Oxford Nanopore
Oxford Nanopore Technologies plc (LSE: ONT) (“Oxford Nanopore”), the company delivering a new generation of nanopore-based molecular sensing technology, and bioMérieux SA, a world leader in the field ...
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Brian Krueger, PhD @h2so4hurts.bsky.social · 12/04/2025
Maybe we should just learn to not believe tech bros when they pretend to know science? cen.acs.org/biological-c...
cen.acs.org
Dire wolf debate raises concerns on scientific overhype
Even de-extinction advocates say that Colossal Biosciences’ claims are misleading
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Brian Krueger, PhD @h2so4hurts.bsky.social · 11/04/2025
The Lac Operon showed us that gene expression can be regulated 🧬 🧪 #histsci
omic.ly
The Lac Operon showed us that gene expression can be regulated
'If gene expression determines the function of a cell, it must be important to control that process?' Yes, very! Let me tell you about the PaJaMo experiment.
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Brian Krueger, PhD @h2so4hurts.bsky.social · 10/04/2025
Translating the Proteome: There’s more to making proteins than just transcribing DNA into mRNA. 🧬 🧪
omic.ly
Translation complicates the proteome, big time!
Translating the Proteome: There’s more to making proteins than just transcribing DNA into mRNA.
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Brian Krueger, PhD @h2so4hurts.bsky.social · 09/04/2025
In a development that should surprise no one, population scale exome screening finds actionable variants. 🧬 🧪
omic.ly
Sequencing exomes in healthy populations pays dividends
In a development that should surprise no one, population scale exome screening finds actionable variants.
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Brian Krueger, PhD @h2so4hurts.bsky.social · 08/04/2025
Oh, good, maybe journalism isn't dead afterall. www.newscientist.com/article/2475...
newscientist.com
No, the dire wolf has not been brought back from extinction
Colossal Biosciences claims three pups born recently are dire wolves, but they are actually grey wolves with genetic edits intended to make them resemble the lost species
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Brian Krueger, PhD @h2so4hurts.bsky.social · 08/04/2025
Well, it also highlights how Colossal's "de-extinction" activities are more of a sideshow than science. Their technology is undoubtably cool, but mutating animals for PR and marketing is just kind of gross.
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Brian Krueger, PhD @h2so4hurts.bsky.social · 08/04/2025
www.scientificamerican.com/article/dire...
scientificamerican.com
Dire Wolves Were Not Really Wolves, New Genetic Clues Reveal
The extinct giant canids were a remarkable example of convergent evolution
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Brian Krueger, PhD @h2so4hurts.bsky.social · 08/04/2025
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Brian Krueger, PhD @h2so4hurts.bsky.social · 04/04/2025
Horseshoe crab blood is our first line of defense against endotoxin contamination of surgical tools and medical devices. Seriously. 🧬 🧪
omic.ly
Horseshoe crab blood to the rescue!
Horseshoe crab blood is our first line of defense against endotoxin contamination of surgical tools and medical devices. Seriously.
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Brian Krueger, PhD @h2so4hurts.bsky.social · 03/04/2025
Proteoforms: This is where things start to get complicated. 🧬 🧪
omic.ly
Proteoforms make proteomics infinitely more complicated than genomics
Proteoforms: This is where things start to get complicated.
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Brian Krueger, PhD @h2so4hurts.bsky.social · 02/04/2025
They recommended me a janitorial position once and I was like, maybe that would be a reasonable career change.
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Brian Krueger, PhD @h2so4hurts.bsky.social · 01/04/2025
Brain storming about nanopore based protein sequencing generates new hypotheses to test 🧬 🧪
omic.ly
Will nanopores enable single molecule protein sequencers?
Brain storming about nanopore based protein sequencing generates new hypotheses to test
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Brian Krueger, PhD @h2so4hurts.bsky.social · 31/03/2025
Welcome to the bambu club!
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Brian Krueger, PhD @h2so4hurts.bsky.social · 28/03/2025
While chromosomes are usually depicted as X's, they actually spend most of their time jumbled up like a giant ball of yarn. #HistSci 🧬 🧪
omic.ly
Hi-C showed us that the genome has topology
While chromosomes are usually depicted as X's, they actually spend most of their time jumbled up like a giant ball of yarn.
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Brian Krueger, PhD @h2so4hurts.bsky.social · 28/03/2025
Details, details....
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Brian Krueger, PhD @h2so4hurts.bsky.social · 27/03/2025
The Proteome: we can’t live without it, but, what actually is it? 🧬 🧪
omic.ly
The proteome is so hot right now
The Proteome: we can’t live without it, but, what actually is it?
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Brian Krueger, PhD @h2so4hurts.bsky.social · 26/03/2025
Clinical evidence is still desperately needed to justify the high cost of liquid biopsy based screening tests (Premium Content)
omic.ly
Liquid Biopsies, are we just faking it until we make it?
HOT TAKE: Clinical evidence is still desperately needed to justify the high cost of liquid biopsy based screening tests
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Brian Krueger, PhD @h2so4hurts.bsky.social · 26/03/2025
I see rambling like a complete moron has caught on again this presidential cycle.
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Brian Krueger, PhD @h2so4hurts.bsky.social · 25/03/2025
Ahhhh, ok, that makes much more sense!! I love my Samsung Galaxy Ultra phones. Also a big fan of OnePlus but they're not quite as nice as the Samsung flagships!
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Brian Krueger, PhD @h2so4hurts.bsky.social · 25/03/2025
Probably not. www.reuters.com/business/hea...
reuters.com
Novo Nordisk expands discounted Wegovy to all cash-paying US customers
Novo Nordisk said on Monday all eligible cash-paying customers in the United States can buy its weight-loss drug Wegovy at a discounted price of $499 per month at their local pharmacy.
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Brian Krueger, PhD @h2so4hurts.bsky.social · 25/03/2025
The quest to find better tolerated weight loss drugs is well on its way and computational drug discovery has already identified at least one promising candidate! 🧬 🧪
omic.ly
In silico identification of a side effect free weight loss peptide
The quest to find better tolerated weight loss drugs is well on its way and computational drug discovery has already identified at least one promising candidate!
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Brian Krueger, PhD @h2so4hurts.bsky.social · 25/03/2025
You haven't had a phone before? Or you broke a 13 year old phone? I can't comprehend either of those...
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Brian Krueger, PhD @h2so4hurts.bsky.social · 24/03/2025
You know this is the right thing for their customers when in the title they say the purpose of the sale is to "maximize stakeholder value." Delete your data NOW. 🧬🧪 investors.23andme.com/news-release...
investors.23andme.com
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Brian Krueger, PhD @h2so4hurts.bsky.social · 21/03/2025
Histones were once thought to just be dumb structural proteins that held chromatin together; now we know that the ‘histone code’ is a major regulator of gene expression. #histSci 🧬 🧪
omic.ly
The formulation of the histone code forever changed our view of the genome
Histones were once thought to just be dumb structural proteins that held chromatin together; now we know that the ‘histone code’ is a major regulator of gene expression.
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Brian Krueger, PhD @h2so4hurts.bsky.social · 20/03/2025
One thing we constantly battle in genomics is, “What does it all mean?” 🧬 🧪
omic.ly
Just because it's in your genes, doesn't mean it's your fate
One thing we constantly battle in genomics is, “What does it all mean?”
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Brian Krueger, PhD @h2so4hurts.bsky.social · 19/03/2025
There's always PFGE... www.bio-rad.com/en-us/catego...
bio-rad.com
Pulsed Field Gel Electrophoresis Systems
Explore Bio-Rad's pulsed-field gel electrophoresis systems: instruments, software, and supplies designed to ensure consistency and run-to-run reproducibility.
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Brian Krueger, PhD @h2so4hurts.bsky.social · 19/03/2025
China gives Illumina some bad news and bans the import of their sequencers (Premium Content)
omic.ly
Turnabout is fair play as Illumina gets caught up in a trade war kerfuffle
China gives Illumina some bad news and bans the import of their sequencers
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Brian Krueger, PhD @h2so4hurts.bsky.social · 19/03/2025
I do realize the president can engage in conflicts, but he can't declare war and congress controls the appropriations process so once the money runs out, it doesn't matter what Donny wants to do.
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