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Guy Leonard

@guyleonard.eurosky.social
917 followers 1.8K following 368 posts

Bioinformatician w/ Tom Richards & Team at @oxfordbiology.bsky.social Homebrewer. WSET Beer Level 2. Rejoiner 🇪🇺🤝🇬🇧 AI is not 'inevitable', resist its uncritical adoption. I unfollow everyone who hypes/uses genAI/LLMs/agentic coding.

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Guy Leonard @guyleonard.eurosky.social · 12/10/2026
We knew Russia interfered in brexit back in 2018 thanks to Carole Cadwalladr. But it's good to finally hear it from the PM! Alao Ukraine bombed data centers in Russia and the bots have almost stopped.
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Guy Leonard @guyleonard.eurosky.social · 02/10/2026
The title of this documentary just reminds me of this episode of Extras... 🤣
Patrick Stewart in Extras. I've seen everything.
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Guy Leonard @guyleonard.eurosky.social · 09/09/2026
I went to see Star Trek IV: The Voyage Home last night as part of its 40th anniversary and Trek's 60th. It was very cool to see it on the big screen! Now I really need LEGO to make a Bird of Prey version ASAP!
A Klingon Bird of Prey hovers over a whaling ship in the ocean. A scene from Star Trek IV.
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Guy Leonard @guyleonard.eurosky.social · 09/09/2026
The queue as of 9am for Dune Pt3 at the BFI IMAX in London. This has got to be all bots surely?
Your queued number is 36157. For dune pt 3 at the BFI IMAX
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Guy Leonard @guyleonard.eurosky.social · 20/08/2026
All good thing must come to an end... #evomics
Evomics workshops are no longer running.
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Guy Leonard @guyleonard.eurosky.social · 07/07/2026
We moved from old biology to new biology today! Long time coming. Need to get used to it!
Picture of a desk with a mini guy doll
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Guy Leonard @guyleonard.eurosky.social · 22/05/2026
E meteorologicos mit Poula. Costa - scorchio! Valle Portos - scorchio! Mi nia kuniaterra exterior - scorchio! Mi nia kuniaterra interior - scorchio! Monto Blanco - scorchio! Meteorologicos manyana - oh, scorchio!
E meteorologicos mit Poula. Costa - scorchio! Valle Portos - scorchio! Mi nia kuniaterra exterior - scorchio! Mi nia kuniaterra interior - scorchio! Monto Blanco - scorchio!

Meteorologicos manyana - oh, scorchio!
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Guy Leonard @guyleonard.eurosky.social · 14/05/2026
I really don't think the RETRACTION of this article is getting enough attention! Both for how Nature will seemingly publish anything if there's an ulterior capitalist agenda behind it, and for how this paper was used to beat people into submission to include LLM use in classrooms.
RETRACTED ARTICLE: The effect of ChatGPT on students’ learning performance, learning perception, and higher-order thinking: insights from a meta-analysis.
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Guy Leonard @guyleonard.eurosky.social · 30/04/2026
"the Greens are committed to getting rid of the unfair First Past the Post voting system...Labour are not." stopreformuk.vote #TacticalVote #greens #StopReform
Hinksey Park: Our advice is to vote Green Party or Labour.

Our analysis of the data...in this area suggests that...Tories and Reform can't win here.
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Guy Leonard @guyleonard.eurosky.social · 17/03/2026
Drinking this on St Guinness advertising day. untp.beer/b0rME Noa Pecan Mudcake Stout.
A glass of stout and can of Omnipollo.
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Guy Leonard @guyleonard.eurosky.social · 09/02/2026
How cool is this blueksy (u)map! haha bluesky-map.theo.io Go find yourself!
Me in a map of blueksy usersMe in a map of blueksy users
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Guy Leonard @guyleonard.eurosky.social · 20/12/2025
Has anyone found a (red) Dark Terry's Chocolate Orange this year yet? There's a real shortage in Oxford! :(
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Guy Leonard @guyleonard.eurosky.social · 30/10/2025
Well, the ChatGPT from Oxford can't even get it right LOL.
LLMs are rubbish. Don't use them.
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Guy Leonard @guyleonard.eurosky.social · 29/10/2025
Online today! De Novo Genome Sequence Assembly of the RNAi-Tractable Paramecium bursaria 186b: An Endosymbiotic Model System academic.oup.com/gbe/article/...
Summary of genome assembly statistics and comparison with other Paramecia genomes. A snail diagram from Blobtools demonstrates the summary assembly data for Pb 186b, including GC content, overall size (Mbp), number and length of the longest scaffold(s), and including the N50/N90 statistics. Circumferential (30 M) and radial scales (365 k) are shown, top right. b) Summary cladogram showing a basic tree topology for three Paramecia species. Genome source data includes Aury et al. (2006), McGrath et al. (2014), He et al. (2019), and Cheng et al. (2020). Species nodes are labeled with BUSCO and OMArk assembly completion statistics (in concentric rings) and evidence of telomere structures is notated when recovered; see key for further details. Question marks denote no candidate telomeric sequences have been found and/or telomeres are unconfirmed in the original assembly source and associated publication. Intron size distribution and dominant intron sequences illustrated using gglogo (Schneider and Stephens et al. 1990) for Pb 186b (c), Pc (d), and Pt (e).
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Guy Leonard @guyleonard.eurosky.social · 27/10/2025
Finally! About time.
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Guy Leonard @guyleonard.eurosky.social · 20/09/2025
The left just eats the left in this country. Meanwhile, the right organises, galvanises and unites. For fuck's sake.
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Guy Leonard @guyleonard.eurosky.social · 28/07/2025
I’m happy to share that I’ve obtained a new certification: WSET Level 2 Award in Beer from Wine & Spirit Education Trust! @wsetglobal.bsky.social certificates.wsetglobal.com/2a1de218-d19...
WSET Level 2 Aware in Beer Certificate
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Guy Leonard @guyleonard.eurosky.social · 08/05/2025
Kirk to Enterprise. Beam up the beasties!
A new Oxford Nanopore Minion device that looks a lot like an Original Series Star Trek communicator.
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Guy Leonard @guyleonard.eurosky.social · 22/04/2025
On this #EarthDay remember - politeness costs nothing - except if you want to blame your users for your poor design in an industry that gives zero-fucks about the environment anyway.
Saying 'Thank You', 'Please' to ChatGPT? It's costing OpenAI 'millions of dollars', says Sam Altman.
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Guy Leonard @guyleonard.eurosky.social · 26/03/2025
If you use any Meta products – Facebook, Instagram, Threads or WhatsApp – you can use the @openrightsgroup.bsky.social tool to request that they no longer collect or process your data for advertising. action.openrightsgroup.org/meta-opt-out
Meta settled a four year court case with human rights campaigner Tanya O’Carroll. She had taken legal action to force the social media giant to stop collecting and processing her personal data for advertising purposes. Meta have agreed to stop profiling Tanya – and now it’s your turn to say no to stalker ads!
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Guy Leonard @guyleonard.eurosky.social · 13/03/2025
"Chatbots were generally bad at declining to answer questions they couldn’t answer accurately, offering incorrect or speculative answers instead. Premium chatbots provided more confidently incorrect answers than their free counterparts." www.cjr.org/tow_center/w... Tell your friends.
The TOW Center asked eight generative search tools to identify the source article, the publication and URL for 200 excerpt extracted from news articles by 20 publishers.  Each square represents the citation behaviour of a response. Perplexity Pro got more things right, about half, compared to Gemini which got almost all wrong.
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Guy Leonard @guyleonard.eurosky.social · 13/01/2025
My amazing codirectors and friends from The Workshop on Genomics gifted to me some wonderful presents for my tenth year helping out on the course! #evomics2025
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Guy Leonard @guyleonard.eurosky.social · 25/11/2024
"Reconstructing the last common ancestor of all eukaryotes" journals.plos.org/plosbiology/... In this Consensus View, we put forth the status quo and an agreed path forward to reconstruct LECA’s gene content. 🧪
 Genetic contributions to LECA.

LECA’s gene repertoire was chimeric, containing genes derived from the Asgardarchaeota-derived host cell, mitochondrial endosymbiont, and potentially other prokaryotic sources, along with a set of eukaryote-specific genes that evolved after the divergence of eukaryotes from prokaryotes.
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Guy Leonard @guyleonard.eurosky.social · 19/11/2024
Nice! 100 citations for "What defines the “kingdom” fungi?" with Tom and Jeremy (who are not here yet). scholar.google.com/citations?vi...
A Google Scholar graph showing the citations by year of the paper from the link. 100 citations!
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Guy Leonard @guyleonard.eurosky.social · 17/09/2024
Bluesky now has over 10 million users, and I was #1,554,519!
1,554,519th user on BlueSky!
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Guy Leonard @guyleonard.eurosky.social · 29/05/2024
Save the date! The Workshop on Genomics 2025 will take place between the 5th and 18th of January, 2025, in beautiful Český Krumlov! Stay updated on the upcoming application process via our social media, website, and newsletter. More details soon! evomics.org/2025-worksho... #evomics2025
SAVE THE DATE
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Guy Leonard @guyleonard.eurosky.social · 02/03/2024
Part 2. Round 2. This time I'm IMAX. Was epic. Very very good. Need to digest. Go see it. #DunePart2
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