Alex Grossman @grossmanmicrobio.bsky.social · 27/05/2026After reading the *released* Epstein files I am legitimately terrified to think it *could* be worse then my current perception. 000
Alex Grossman @grossmanmicrobio.bsky.social · 15/05/2026Correct, not one dollar that could be used to benefit humanity or Americans will go unstolen by the tech-industrial-military complex. 030
Reposted by Alex GrossmanJacquelyn Gill @jacquelyngill.bsky.social · 14/05/2026Cool, so NSF is now going to be used to essentially launder money to tech bros because universities are just too cumbersome and disciplinary oversight and regulations and accountability are all just too stifling for innovation. $1.5B for “X-Labs.”nsf.govNSF X-LabsNSF's mission is to advance the progress of science, a mission accomplished by funding proposals for research and education made by scientists, engineers, and educators from across the country. 27816404
Reposted by Alex GrossmanIlnam Kang @ilnamkang.bsky.social · 11/05/2026Interesting results from continuous cultivation of co-cultures of a host bacterium and episymbiotic Patescibacteria Resolving Host-Episymbiont Interaction Dynamics through Continuous Cultivation www.biorxiv.org/content/10.6...biorxiv.org 033
Alex Grossman @grossmanmicrobio.bsky.social · 11/05/2026I love both the Princess Donut and Cenobite Grogu mascots. 110
Alex Grossman @grossmanmicrobio.bsky.social · 11/05/2026Ecstatic to announce our newest preprint, using modular bioreactors to show that ultrasmall episymbiotic bacteria have diverse impacts on host communities; ranging from mild inhibition to severe inhibition with oscillating "arms race" population dynamics. www.biorxiv.org/content/10.6...biorxiv.org 020
Alex Grossman @grossmanmicrobio.bsky.social · 12/02/2026It's funny, my PhD advisor Dr. Goodrich-Blair would also tell stories about those exact lectures. Must have made an incredible impression! I'll do some reading and find out if anything looks like what we see in our episymbionts. I do think we're just about ready to dive into CPR regulation pathways. 411
Alex Grossman @grossmanmicrobio.bsky.social · 10/02/2026That being said, pilin expression and pili-dependent twitching is induced by host exposure. We have quantified piliation of unattached cells (~7 per cell) via CryoEM, however the host cells are so much more electron dense that we could not quantify from an attached cell. 2/2 doi.org/10.1093/isme...doi.orgSaccharibacteria deploy two distinct type IV pili, driving episymbiosis, host competition, and twitching motilityAbstract. All cultivated Patescibacteria, also known as the candidate phyla radiation, are obligate episymbionts residing on other microbes. Despite being 321
Alex Grossman @grossmanmicrobio.bsky.social · 10/02/2026Hello Steve! I wish I had a better answer for you, we are looking, but we do not know yet how Saccharibacteria are regulating their natural competence. We know they have 2 distinct pili (thick and thin) and a T4SS. The thin pili isn't needed for competence, but the thick pili of T4SS could be? 1/2 121
Reposted by Alex GrossmanAbish Stephen @astephen.bsky.social · 05/01/2026Ultrasmall episymbiont Nanosynbacter lyticus employs multiple ATP-generating metabolic pathways during horizontal transmission #microsky 🧪 academic.oup.com/ismej/articl...academic.oup.comUltrasmall episymbiont Nanosynbacter lyticus employs multiple ATP-generating metabolic pathways during horizontal transmissionAbstract. Saccharibacteria (formerly TM7) are a group of environmentally diverse, ultrasmall bacteria with highly reduced genomes belonging to Patescibacte 132
Reposted by Alex GrossmanH. B. Beryl Rappaport @hbrappap.bsky.social · 25/11/2025So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth! #protistsonsky 🧵 16506166
Alex Grossman @grossmanmicrobio.bsky.social · 15/10/2025Hello everyone, take a look at my cool bugs from the Microbial Dark Matter phylum Saccharibacteria! These ultrasmall bacteria (in green) track down Actinobacteria hosts (not in green) and grow on the host cell envelope. 12611
Reposted by Alex GrossmanBat Bor @batbilegbor.bsky.social · 03/06/2025Exciting progress! In our new preprint, we show that episymbiont Saccharibacteria can directly modulate epithelial immunity—a big step in understanding how these elusive microbes interact with the human host. Kudos to Deepak Chouhan and our amazing collaborators! www.biorxiv.org/content/10.1... 01810
Alex Grossman @grossmanmicrobio.bsky.social · 21/05/2025New paper out! We searched for cargo across thousands of Type 11 Secretion Systems (T11SS) in Proteobacteria and uncovered 2,500+ predicted secreted proteins, including 6 novel cargo types, with experimental verification of a new surface lipoprotein, Pls. doi.org/10.1099/mgen.0.001406 095
Reposted by Alex GrossmanBat Bor @batbilegbor.bsky.social · 04/12/2024Excited to share our new preprint on the detailed investigation of Type 4 pili in epibiont oral Saccharibacteria! Led by Alex Grossman from our lab, and with Jun Liu (Yale), Jeff McLean (UW) and Xuesong He. Check it out: biorxiv.org/content/10.1... 02211