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Gleason Research Group

@gleason-group.bsky.social

296 followers 43 following 8 posts

Organic and Medicinal Chemistry at McGill University Group website: gleason-group.mcgill.ca

Posts Replies Media

Gleason Research Group @gleason-group.bsky.social · 10/07/2026

@revvity.bsky.social My version of Chemdraw just updated. You took a method for incorporating atom labels (simply double-clicking on an atom) that has been used by everyone for nearly 30 years and ditched it for a clunky left click to pull down a menu. Why change something that is so ingrained in

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Reposted by Gleason Research Group

Alex Usher @alexusherhesa.bsky.social · 20/02/2026

Long national nightmare ending?

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Gleason Research Group @gleason-group.bsky.social · 18/02/2026

We were pleased to have Tim Cernak yesterday for the annual G. Ron Brown lecture. Always great to host a former student.

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Gleason Research Group @gleason-group.bsky.social · 03/03/2025

Congrats to Anthony Izzotti on a successful thesis defence. Amazing work on cyclopropane expansions, conformational effects of spirocyclopropane-cyclohexanes and once and for all proving that the [14+2] cycloaddition of heptafulvalene is not a Woodward-Hoffman controlled process.

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Gleason Research Group @gleason-group.bsky.social · 08/02/2025

This looks like a disaster for US University funding.

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Gleason Research Group @gleason-group.bsky.social · 07/11/2024

A nice write-up of our recent work on the axial-promoting effect of cyclopropanes. www.chemistryworld.com/news/cyclopr...

chemistryworld.com

Cyclopropyl effect causes substituents on cyclohexane to favour axial conformation

'Unusual stereocontrol element' will help medicinal chemists increase three-dimensionality of drug candidates

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Gleason Research Group @gleason-group.bsky.social · 09/10/2024

For our first Blue Sky post: Our paper on the surprising effect of cyclopropanes on A-values is now out (in preliminary form) in Chem. Sci. If you want to push a large or electronegative group axial on a ring, just stick a cyclopropane next to it. pubs.rsc.org/en/content/a...

pubs.rsc.org

Driving tert-Butyl Axial: The Surprising Cyclopropyl Effect

The presence of a small spirocyclic ring at an adjacent position alters the conformational preference for equatorial substitution in six-membered rings. DFT calculations and low-temperature 1H NMR exp...

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